http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계
신영신(Young Shin Shin),김영옥(Young Ok Kim),박철휘(Chul Whee Park),윤성노(Sung No Yoon),양철우(Chul Woo Yang),김용수(Yong Soo Kim),장윤식(Yeun Sik Jang),방병기(Byung Kee Bang),한훈(Hoon Han) 대한내과학회 1998 대한내과학회지 Vol.54 No.2
designed to evaluate the pattern of histocompatibility antigens(HLA) and its association with poor prognostic factors in patients with IgAN. Methods : Study population comprised the 69 patients with IgAN which was diagnosed by clinical and pathological findings, and control groups were 202 healthy Korean people. We evaluated the HLA class I serologic typing by standard microlymphocytotoxic technique and the HLA class II genotypes by the two-step polymerase chain reaction. Results : 1. HLA-A was not associated with IgAN. 2. The phenotype frequency of HLA-B55 was 6.1% in patient group and 1.7% in normal control group. HLA- B55 was associated with IRAN(relative risk 3.47, P<0.05). 3. HLA-DQB1*04 was also associated with IgAN (relative risk 3.57, P<0.05). 4. There was no significant difference in the distribution of HLA in IgAN patients according to histologic grading, blood pressure, renal function and proteinuria. Conclusions : Frequencies of HLA-B55, HLA-DQB1*04 are higher in Korean patients with IgAN compared to general population. But we could not observe the significant relationships between HLA type and poor prognostic factors. Further study using larger population with IgAN may be necessary to identify the association of HLA locus with poor prognostic factors and progress decline in renal function in patients with IgAN.
자활사업 참여자의 자립 의지와 인지된 고용 장벽이 경제적 자활에 미치는 영향
신영신(Shin Young Sin) 한국비영리학회 2016 한국비영리연구 Vol.15 No.2
자활사업은 참여자의 자립능력을 향상시키고, 공공부조제도에서 벗어나게 하기 위하여 시행되었다. 이후 자활사업의 효과성을 측정하는 연구들이 진행되어 왔으며, 성공적인 경제적 자활로의 과정으로 자활의지의 중요성이 강조되어 왔다. 또한, 자활사업은 참여자들의 취업·창업을 통하여 탈수급을 목표로 하고 있고, 인지된 고용 장벽은 취업에 영향을 미치는 중요한 요인으로 경제적 자활에 영향을 미친다. 본 연구는 자활사업 참여자들의 경제적 자활에 영향을 미치는 요인으로 자립의지와 인지된 고용 장벽이 경제적 자활에 미치는 영향을 검증하고자 하였다. 이를 위해 경기 지역 자활센터 참여자 288명을 대상으로 설문한 자료를 이용하여 다중회귀분석을 실시하였다. 분석결과, 독립변수인 자립의지는 경제적 자활에 정적인 영향을 미치고, 인지된 고용 장벽은 부적인 영향을 미치는 것을 확인할 수 있었다. 즉, 자활사업 참여자의 자립의지가 높아지고, 인지된 고용 장벽이 낮아지면 경제적 자활이 높아진다고 해석할 수 있다. 이러한 연구결과를 바탕으로 본 연구에서는 자활사업 참여자의 경제적 자활을 높일 수 있는 방안으로서 자립의지 향상 프로그램 시행 및 사례관리의 중요성에 대한 방안을 제시하고자 하였다. A self-support program is intended to improve self-reliance of its participants so that they are able to stay away from or at least minimize their dependence on the public assistance system. A lot of studies have been conducted in a bid to measure the effectiveness of self-support programs with emphasis on the importance of employment hope as part of the process toward successful economic self-sufficiency. In addition, self-support programs aim to enable their participants to stand on their feet instead of relying on help from government through employment or starting their own business, and the perceived employment barriers affect economic self-reliance as a major factor that influences employment. Against this backdrop, this study intends to verify the effect of employment hope and perceived employment barriers of self-support program participants on economic self-reliance. For this, multiple regression analysis has been conducted using data obtained from surveys among 288 participants of Gyeonggi Regional Self-Support Center. The surveys have found that the employment hope as an independent variable has a statistically significant effect on the economic self-sufficiency while the perceived employment barrier has a negative effect on it. In other words, it can be interpreted that the higher the employment hope of self-support is and the lower the perceived employment barriers become, the higher the economic self-sufficiency will be. Based on these findings, this study aims to propose ways as to the implementation of employment hope improvement programs and case management as a way to enhance the economic self-reliance of those who participate in self-support programs.
신장질환이 없는 80세 이상 노인에서 초음파로 측정한 신장의 크기
신영신 ( Young Shin Shin ),박수연 ( Soo Yun Park ),진동찬 ( Dong Chan Jin ),김형욱 ( Hyung Wook Kim ),김용수 ( Yong Soo Kim ),장윤식 ( Yoon Sik Chang ),방병기 ( Byung Kee Bang ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4
목적: 신장의 크기가 9 cm 미만인 경우 비가역적인 신장질환을 시사한다고 알려졌고, 한국 정상 성인의 초음파촬영술로 측정한 신장의 크기는 8.76 cm와 12.36 cm가 정상 하한치와 상한치로 제시되었다. 그러나 나이에 따른 신장 기능의 변화는 다른 장기와 마찬가지로 성장이 끝난 이후 차츰 감소하는 것으로 나타나고 있어 80세 이상의 고령에서 적용 여부는 논란이 될 수 있다. 이에 본 연구자들은 신장질환이 없는 80세 이상 고령 노인에서의 신장크기 및 신기능의 지표인 혈청 크레아티닌 (Scr)와 신기능 평가에 이용되는 Cockcroft-Gault (C-G)공식 및 Modification of Diet in Renal Disease (MDRD) 공식과 신장크기와의 상관여부를 알아보고자 하였다. 방법: 대상은 복부 초음파촬영술을 실시한 80세 이상의 노인 150명 중 Scr이 1.3 이하이고, 계산된 사구체 여과율이 60 mL/min/1.73m2 이상이면서 당뇨병과 단백뇨 및 요로 감염이 없는 106명이었다. 평균나이는 83±0.3세 (남자 82±0.4세, 여자 84±0.5세)였다. 결과: 1) 신장크기는 9.9±0.07 cm (최소 7.7 cm, 최대 11.3 cm)였고, 남자에서 더 컸다. 2) 신장크기는 90세 이후가 80대 초반보다 작았다. 3) 신장크기는 연령과 의미 있는 음의 상관관계, Scr과는 통계적 의미는 없으나 음의 상관관계였다. 신체계수는 체표면적이 관련 있었다. 4) 계산에 의한 사구체 여과율 (GFR) 중, C-G 공식은 양측신장의 표면적과 MDRD 공식은 양측신장의 평균값과 관련 있었다. 5) Scr과 C-G 및 MDRD 공식에 의한 GFR은 음의 상관관계였으며, MDRD 공식이 통계적으로 의미 있게 나타났다. 결론: 이상의 결과에서 80세 이상의 노인에서 신장크기는 현재 알려진 정상 성인보다 작을 수 있고, 단순 길이뿐 아니라 단면적, 그리고 체표면적을 포함한 신체 인자도 측정하여야 그 환자에서의 신장크기의 정상 여부를 알 수 있을 것이며, 추후 노인에서 정확한 GFR 측정 방법과 일반 성인과 다른 정상 및 비정상 상태에 대한 더 많은 연구가 필요하리라 여겨진다. Purpose: Kidney size (KS) is used to diagnose the patients with renal disease. When the length of a kidney is measured under 9 cm, it is considered to indicate an irreversible disease. Because glomerular filtration rate (GFR) decreases with age, the normal range of KS in the elderly is indefinite. Therefore, we measured KS in adults older than 80 years old and investigated correlated factors. Methods: One hundreds six adults (51 men, 55 women: mean age 83±0.3) without renal disease were included. Their serum creatinine (Scr) levels did not exceed 1.3 mg/dL, and the calculated GFR were over 60 mL/min/1.73m2. Abdominal ultrasonography were performed to all of them and their body indexes (BI) were measured. Results: 1) The mean length of kidney was 9.9±0.07 cm. 2) KS in the early eighties was larger than that of adults over ninety. 3) KS showed negative correlations with age and Scr, but a positive correlation with body surface area. 4) The calculated GFR showed correlations with the surface areas of both kidney (BK) by C-G equation and with the size of BK by MDRD equation. 4) The GFR calculated by MDRD and C-G equation presented inverse correlations with Scr, but only MDRD equation showed a statistic significance. Conclusion: In the elderly, KS may be smaller than that of younger adults. Other factors such as either surface area or volume of BK and BI should be considered to estimate the individual KS to decide whether the size is within normal range.
제2형 당뇨병 환자에서 당뇨병성 신증과 비당뇨병성 신질환의 임상적 차이
김병수 ( Byung Soo Kim ),장윤경 ( Yoon Kyoung Chang ),송호철 ( Ho Cheol Song ),이소영 ( So Young Lee ),장세나 ( Se Na Jang ),김형욱 ( Hyung Wook Kim ),신영신 ( Young Shin Shin ),최영진 ( Young Jin Choi ),진동찬 ( Dong Chan Jin 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Purpose: It is important to differentiate non-diabetic renal diseases (NDRD) from diabetic nephropathy (DN) in type 2 diabetes. Our study was reviewing the clinical data and treatment strategies from diabetic patients performed renal biopsy to determine the clinical indicators suggestive of NDRD. Methods: We reviewed the medical records of type 2 patients who underwent renal biopsy from Jan. 1995 to Dec. 2007. Results: Seventy four patients were included. Mean age was 52.0±12.5 years and 41 (55%) patients were male suddenly developed. Nephrotic syndrome [34 cases (46%)] was the leading reason for renal biopsy. There were 37 cases (50%) with a pathologic diagnosis of DN, 31 (42%) with NDRD, and 6 (8%) with concurrent DN and NDRD. IgA nephropathy (35%) was the most common lesion found in patients with NDRD. Thirty one patients (84%) with DN and 26 (84%) with NDRD had follow-up periods of more than 6 months. Of 26 patients with NDRD, 12 were treated with immune suppressants and 6 achieved complete remission. Thirteen patients with DN and one with NDRD developed end-stage renal disease. Patients with NDRD tended to show shorter duration of diabetes, lower systolic blood pressure (SBP) and lower serum triglyceride, and had significantly lower incidence of diabetic retinopathy (DR). In the univariate regression analysis, diabetes duration, SBP, triglyceride and DR showed statistically significance. And SBP and DR were identified as independent correlating factors by multivariate regression analysis. Conclusion: In this study, the absence of retinopathy could predict the presence NDRD among NIDDM patients presenting with renal disease. And additional disease-specific therapies may be helpful for the patients with NDRD.
유지한 ( Ji Han Yu ),신영신 ( Yeong Sin Shin ),정현주 ( Hyun Ju Jung ),윤유선 ( Yu Seon Yun ),김현경 ( Hyun Gyung Kim ),김영수 ( Yooung Soo Kim ),윤선애 ( Sun Ae Yoon ),김용수 ( Yong Soo Kim ),김영옥 ( Young Ok Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.1
Purpose: Acute alcohol intoxication (AAI) causes various complications such as electrolyte imbalance, alcoholic ketoacidosis (AKA), rhabdomyolysis, and acute kidney injury (AKI). Although there have been some reports about AKA and rhabdomyolysis, AKI due to acute alcohol intoxication is rarely reported. Methods: We retrospectively evaluated the medical records of 371 patients with AAI between January 2004 and May 2010 in Uijeongbu St. Mary`s Hospital. We compared the clinical findings, morbidity and mortality rate between AKI and normal kidney function (NKF) groups. Results: Of the total 371 patients with AAI, AKI occurred in 107 patients (28.8%). The peak serum creatinine level in AKI patients was 2.9±1.9 mg/dL. Thirteen of the 107 patients (12.1%) received renal replacement therapy. AKI group had higher incidence of decreased mentality (29.0% vs 16.3%, p= 0.006), dyspnea (11.2% vs 4.9%, p=0.029) and hypotension (66.0% vs 41.7%, p<0.001), and lower incidence of gastrointestinal bleeding (22.4% vs 34.8%, p=0.019), compared to NKF group. The AKI group also had higher incidence of ketoacidosis (78.5% vs 28.8%, p<0.001), rhabdomyolysis (19.6% vs 4.2%, p<0.001), and pneumonia (22.4% vs 8.0%, p<0.001), compared to NKF group. The length of ICU stay was longer (7.4±10.8 vs 4.1±6.1 days, p=0.003) and the mortality rate was higher (17.8% vs 2.3%, p<0.001) in AKI group. Conclusion: This study demonstrated that incidence of AKI in patients with AAI was 28.8% and AKI was associated with high morbidity and mortality. And multivariate analysis demonstrated that independent risk factors of AKI were ketoacidosis and increased serum osmolality.