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원발성 폐암에서 혈장 과립구 자극인자의 암표지자로서의 역할과 의의
송정섭 ( Jung Sub Song ),김소영 ( So Young Kim ),조향정 ( Hyang Jeong Jo ),이강규 ( Kang Kyoo Lee ),신정현 ( Jeong Hyun Shin ),신성남 ( Seong Nam Shin ),김동 ( Dong Kim ),박성훈 ( Seong Hoon Park ),이영진 ( Young Jin Lee ),고창보 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.6
연구배경: 폐암은 진단 당시에 완치할 수 있는 확률이 적어 예후가 불량한 종양으로 알려져 있어, 폐암 진행을 예측할 수 있는 암 표지자(tumor marker)의 발굴이 필요한 실정이다. 그러나 폐암에서 아직까지 특이적인 항원이 없고 현재까지 알려진 많은 종양관련 항원들의 민감도가 떨어지기 때문에 보편화되지 못하고 있다. 본 연구에서는 원발성 폐암 환자에서 혈장 G-CSF를 측정하고 암의 진행 및 예후와 관련이 있는지 알아보고자 하였다. 방법: 원발성 폐암으로 진단된 100명 환자와 건강 검진에서 이상 소견이 없는 127명 정상인을 대상으로 하였다. 결과: 정상인에서 혈장 G-CSF 농도는 12.2±3.6 pg/mL (mean±SD), 폐암환자에서는 46.0±38.0 pg/mL였다(p<0.001). 비소세포폐암에서 G-CSF 농도는 유의하게 소세포폐암보다 높았으며(p<0.05), 비소세포 폐암중 대세포 폐암이 가장 높았고, 편평세포암, 선암, 세기관지폐포암 순이었다. G-CSF 농도는 국소형보다는 진행형 비소세포폐암에서 증가하는 경향을 보였다. 또한 타 장기로의 전이가 있을 때 유의하게 증가하였으며(p<0.05), 다발성 전이에서는 뇌, 부신, 골 전이 순으로 혈청 G-CSF 농도가 증가하는 경향이었다. 결론: 혈장 G-CSF 농도는 폐암이 진행한 경우, 특히 타 장기로의 전이가 있을 때 유의하게 증가하였다. 그러므로 진행형 폐암의 추적관찰에 이용할 수 있으리라 사료된다. Background: Biomarkers for cancer have several potential clinical uses, including the following: early cancer detection, monitoring for recurrence prognostication, and risk stratification. However, no biomarker has been shown to have adequate sensitivity and specificity. Many investigators have tried to validate biomarkers for the early detection and recurrence of lung cancer. To evaluate plasma G-CSF as such a biomarker, protein levels were measured and were found to correlate with the clinicopathological features of primary lung tumors. Methods: Between December 2006 and May 2008, 100 patients with histologically-validated primary lung cancer were enrolled into this study. To serve as controls, 127 healthy volunteers were enrolled into this study. Plasma G-CSF levels were measured in lung cancer patients using the sandwich ELISA system (R & D inc.) prior to treatment. Results: The mean plasma G-CSF levels were 12.2±0.3 pg/mL and 46.0±3.8 pg/mL (mean±SE) in the normal and in the cancer groups, respectively. In addition, plasma G-CSF levels were higher in patients with early lung cancer than in healthy volunteers (p<.001). Plasma G-CSF levels were higher in patients who were under 65 years old or smokers. Within the cancer group, plasma G-CSF levels were higher in patients with non small cell lung cancer than in patients with small cell lung cancer (p<.05). Overall, plasma G-CSF levels were shown to increase dependent upon the type of lung cancer diagnsosed. In the order from highest to lowest, the levels of plasma G-CSF tended to decrease in the following order: large cell carcinoma, squamous cell carcinoma, adenocarcinoma, and bronchioloalveolar carcinoma. Plasma G-CSF levels tended to be higher in patients with advanced TNM stage than in localized TNM stage (I, II<III, IV). Increased levels were also seen in patients with distant metastasis in the order of bone, adrenal gland involvement. Conclusion: Plasma G-CSF level were significantly increased in patients with lung cancer, and in especially advanced TNM stage. These results suggest that plasma G-CSF can be used to support the diagnostic process of lung cancer staging and as an indicator of metastasis.
기관지천식 마우스에서 기저막하 섬유화와 관련된 인자들: TGF-β1및 IL-17에 대한 CpG-oligodeoxynucleotides의 영향
송소향 ( So Hyang Song ),김치홍 ( Chi Hong Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.2
Background: Important features of airway remodeling in asthma include the formation of subepithelial fibrosis and increased deposition of collagen. Profibrotic cytokines such as TGF-β1 and IL-17 are involved in the formation of subepithelial fibrosis and are increased in patients with asthma, particularly in these severe disease. Previous reports have represented that administration of CpG-oligodeoxynu-cleotides (CpG-ODN) before allergen sensitization or challenge inhibits chronic inflammation and remodeling of airway in mice with chronic asthma, but the effect of CpG-ODN on TGF-β1 and IL-17 have not been evaluated. Objective: To evaluate the effect of CpG-ODN on the expression of these profibrotic cytokines and on collagen deposition, this study was performed in mice with chronic asthma. Method: Mice were subjected to repetitive ovalbumin (OVA) challenge for 2 months. CpG-ODN was administered intraperitoneally for sensitization. After the final challenge, airway hyperresponsiveness, peribronchial fibrosis, and levels of lung hydroxyproline were assessed. Levels of TGF-β1 and IL-17 in bronchoaveolar lavage (BAL) were assessed by ELISA and the number of TGF-β1+cells and IL-17+cells in peribronchial area by immumohistochemistry. Result: CpG-ODN significantly reduced airway hyperresponsiveness, eosinophil infiltration, and peribronchial fibrosis. Levels of TGF-β1 in BAL fluid (353±94 vs 270±66 pg/mL, OVA vs OVA+CpG, P<0.05) and peribronchial TGF-β1+cells (46±10 vs 27±5 TGF-β1+ cells/bronchus, OVA vs OVA+CpG, P<0.01) were significantly reduced in mice treated with CpG-ODN. Levels of IL-17 in BAL fluid (62±30 vs 34±10 pg/mL, OVA vs OVA+CpG, P=0.074) were not significantly reduced, but peribronchial IL-17+cells (27±7 vs 7.5±5.3 IL-17+ cells/bronchus, OVA vs OVA+CpG, P<0.01) and levels of lung hydroxyproline (13.1±5.3 vs 9.1±2.71ug/mL, OVA vs OVA+CpG, P<0.01) were significantly reduced in mice treated with CpG-ODN. Conclusion: CpG-ODN significantly reduced the levels of allergen-induced peribronchial fibrosis and collagen deposition. The reduction in peribronchial fibrosis and collagen deposition mediated by CpG-ODN might be due to several mechanisms including inhibition of profibrotic cytokines of TGF-β1 and IL-17 and a reduction in the number of peribronchial inflammatory cells expressing TGF-β1. (Korean J Asthma Allergy Clin Immunol 2006;26:136-144)
만성폐쇄성폐질환의 급성악화와 회복기에서 유도객담 내 Nuclear Factor-κB (NF-κB)의 활성도와 IL-6, IL-8 및 TNF-α의 농도 변화
송소향 ( So Hyang Song ),김치홍 ( Chi Hong Kim ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2
연구배경 : COPD의 급성악화는 세균에 의한 감염, 바이러스성 상기도 감염, 대기오염, 기후변화 등에 의하며, COPD의 급성악화 시에 객담 내 호중구의 증가, IL-6와 IL-8 농도의 증가, 그리고 산화질소의 증가는 NF-κB의 활성화와 관련된 것으로 알려져 있다. 그러므로 COPD의 병인 및 급성악화의 기전에 NF-κB 활성도와 IL-6, IL-8 및 TNF-α가 관련이 있는지 연구하고자 하였다. 방법 : 정상대조군 및 COPD로 입원하였던 환자 Background : Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the NF-κB is known to be an indicator of cellular activation and of inflammatory mediator production. This stud
진행된 비소세포 폐암 환자에서 Concurrent Chemoradiotherapy 와 Conventional Radiotherapy의 비교
김휘정 ( Hui Jung Kim ),이동수 ( Dong Soo Lee ),송소향 ( So Hyang Song ),정수미 ( Su Mi Jung ),김영균 ( Young Kyoon Kim ),윤세철 ( Se Chul Yoon ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.3