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RISS 인기검색어
- 검색키워드
- 저자 : 송정석 ( Young Sook Im (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Dehydro-L-Ascorobic Acid의 대사에 대한 연구 Dehydro-L-Ascorbic Acid의 이동에 관하여
임영숙,김용수,송정석,Im, Young-Sook,Kim, Yong-Soo,Song, Chung-Suk 생화학분자생물학회 1977 한국생화학회지 Vol.10 No.1
L-Ascorbic acid(ASA) 및 dehydro-L-ascorbic(DHA)의 대사를 연구하기 위하여 ASA 혹은 DHA 500mg을 토끼의 소장내 주입하고 시간마다 혈액내 농도와 주입후 5시간후의 각 장기 (신장, 간장, 대 뇌, 소장)내 ASA 및 DHA의 농도를 측정하고 또 ASA 혹은 DHA를 토끼에게 정맥 주사하고 혈액 내 ASA와 DHA의 농도를 시간적으로 관찰하고 90분후에 각 장기내 ASA 및 DHA의 농도를 관찰하여 다음과 같은 결론을 얻었다. (1) 소장에서 ASA는 DHA 보다 더 빨리 흡수되었다. (2) 혈액에서 ASA 는 DHA보다 더 빨리 조직으로 이동되었다. (3) ASA 및 DHA를 정맥주사하고 90분후 각 장기 (간장, 신장, 대뇌, 소장)의 ASA 및 DHA의 농도를 관찰한 바 ASA를 주사한 경우가 DHA를 주사한 경우보다 높았다. 그러나 소장에 ASA 및 DHA를 주입한 토끼에서 주입후 5시간 후의 각 장기의 ASA 및 DHA농도가 대조군에 비해 별 변화가 없는 것은 각 장기에 들어온 ASA 및 DHA가 이미 파괴되어 정상치로 떨어지기 때문이라 생각된다. For the studies on the metabolism of L-ascorbic acid (ASA) and dehydro-Lsascorbic acid (DHA), 500mg of ASA or DHA were administrated directly into the small intestines of rabbits and the levels of the vitamin in the blood were determined at one hour intervals and the levels of the vitamin in organs (liver, kidney, brain and small intestine) also were determined five hours after administration of the vitamin, ASA or DHA (10, 30 and 60mg) were also injected intravenously into the rabbits and the levels of the vitamin in blood were determined at intervals until 90 minutes and the vitamin in organs also were determined 90 minutes after the injection and the following results were obtained. 1) ASA was absorbed faster at the small intestine than DHA. 2) ASA was transfered faster than DHA from the blood to the tissues. 3) The levels of the vitamin in each organs (liver, kidney, brain and small intestine) were determined 90 minutes after injection of ASA or DHA intravenously. The levels of the vitamin in each organs were higher in case of administration of ASA than in case of DHA. But the levels of the vitamin in each organs 5 hours after administration of ASA or DHA into small intestine directly showed no difference when compared with those of the control. This is probably due to the destruction of the ASA or DHA transfered to the tissues down to the normal levels.
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Dehydro - L - Ascorobic Acid 의 대사에 대한 연구 , Dehydro - L - Ascorbic Acid 의 이동에 관하여
임영숙,김용수,송정석 ( Young Sook Im,Yong Soo Kim,Chung Suk Song ) 생화학분자생물학회 1977 BMB Reports Vol.10 No.1
For the studies on the metabolism of L-ascorbic acid (ASA) and dehydro-L-ascorbic acid (DHA), 500㎎ of ASA or DHA were administrated directly into the small intestines of rabbits and the levels of the vitamin in the blood were determined at one hour inter vals and the levels of the vitamin in organs (liver, kidney, brain and small intestine) also were determined five hours after administration of the vitamin. ASA or DHA (10, 30 and 60㎎) were also injected intravenously into the rabbits and the levels of the vitamin in blood were determined at intervals until 90 minutes and the vitamin in organs also were determined 90 minutes after the injection and the following results were obtained. 1) AS A was absorbed faster at the small intestine than DHA. 2) ASA was transfered faster than DHA from the blood to the tissues. 3) The levels of the vitamin in each organs(liver, kidney, brain and small intestine) were determined 90 minutes after injection of ASA or DHA intravenously. The levels of the vitamin in each organs were higher in case of administration of ASA than in case of DHA. But the levels of the vitamin in each organs 5 hours after administration of ASA or DHA into small intestine directly showed no difference when compared with those of the control. This is probably due to the destruction of the ASA or DHA transfered to the tissues down to the normal levels.
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