학동기 및 사춘기 아토피피부염 환아에서 메타콜린 기도과민성에 영향을 미치는 요인에 대한 분석

성명순 ( Myong Soon Sung ),최진욱 ( Jin Wook Choi ),황영진 ( Young Jin Hwang ),김성원 ( Sung Won Kim ) 대한소아알레르기호흡기학회 1992 소아알레르기 및 호흡기학회지 Vol.2 No.3

Purpose: Many studies have shown the importance for bronchial hyperresponsiveness (BHR) in children with bronchial asthma and allergic rhinitis. However, studies have not been done in BHR in school age and adolescence with atopic dermatitis (AD). Methods: The patients with history of bronchial asthma were excluded and methacholine challenge test (MCT) was performed in 103 children with atopic dermatitis. The positive of MCT result is defined as provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (PC20)≤8 mg/mL. According of the level of PC20, the patients were divided into two groups. Results: The group 1 (BHR+) was observed in 43 of all patients (41.7%). Of two groups, significant differences were observed in age, body mass index. No significant differences were observed in the number of male, SCORing Atopic Dermatitis (SCORAD) index, admission history, smoking exposure history, other allergic disease, parental allergic disease. The group 1 (BHR+) have higher levels of total eosinophil count compared with the group 2 (BHR.) (629.8±360.5/μL vs. 470.2±253.9/μL, P=0.01). But no significant association was found between severity of BHR and SCORAD score, total immunoglobulin E, total eosin ophil count and eosinophil cationic protein (r=0.008, P=0.961; r=.0.217, P=0.162; r=0.225, P=0.147; r=.0.032, P=0.841). The list of allergen is that the house dust mite, tree, weed, food, animal hair, and fungus. The house dust mite has correlation with bronchial hypersensitivity statistically and the any of allergen groups, either. Conclusion: No significant relationship was observed between degree of BHR and allergy laboratory finding, severity of AD. (Allergy Asthma Respir Dis 2014;2:179-186)

학동기 및 사춘기 아토피피부염 환아에서 메타콜린 기도과민성에 영향을 미치는 요인에 대한 분석

성명순 ( Myong Soon Sung ),최진욱 ( Jin Wook Choi ),황영진 ( Young Jin Hwang ),김성원 ( Sung Won Kim ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.3

Purpose: Many studies have shown the importance for bronchial hyperresponsiveness (BHR) in children with bronchial asthma and allergic rhinitis. However, studies have not been done in BHR in school age and adolescence with atopic dermatitis (AD). Methods: The patients with history of bronchial asthma were excluded and methacholine challenge test (MCT) was performed in 103 children with atopic dermatitis. The positive of MCT result is defined as provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (PC20)≤8 mg/mL. According of the level of PC20, the patients were divided into two groups. Results: The group 1 (BHR+) was observed in 43 of all patients (41.7%). Of two groups, significant differences were observed in age, body mass index. No significant differences were observed in the number of male, SCORing Atopic Dermatitis (SCORAD) index, admission history, smoking exposure history, other allergic disease, parental allergic disease. The group 1 (BHR+) have higher levels of total eosinophil count compared with the group 2 (BHR-) (629.8±360.5/μL vs. 470.2±253.9/μL, P=0.01). But no significant association was found between severity of BHR and SCORAD score, total immunoglobulin E, total eosin ophil count and eosinophil cationic protein (r=0.008, P=0.961; r=-0.217, P=0.162; r=0.225, P=0.147; r=-0.032, P=0.841). The list of allergen is that the house dust mite, tree, weed, food, animal hair, and fungus. The house dust mite has correlation with bronchial hypersensitivity statistically and the any of allergen groups, either. Conclusion: No significant relationship was observed between degree of BHR and allergy laboratory finding, severity of AD.

15년 동안 부산 지역에서 채집된 공중화분 분포 및 알레르기 감작률과의 상관관계

성명순 ( Myong Soon Sung ),박영진 ( Yong Jin Park ),박근화 ( Geun Hwa Park ),오재원 ( Jae Won Oh ),김성원 ( Sung Won Kim ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.1

Purpose: pollen is the most common causative agents of allergic disease. Since 2000, there isn``t no more report about pollen in Busan. This study is that pollen in one area of Busan was collected to investigate species, particle counts, seasonal distribution, and of its correlation with reactivity to skin prick test in children during 1998.2012. Methods: Rotorod sampler was installed on the rooftop of St. Mary Hospital in Busan. A 24-hour sampling of allergens over a fifteen-year period was conducted 6 days/wk from January 1, 1998 to December 31, 2012. After staining they were identified, counted and recorded with the weather in Busan. Results: Major pollens collected were Pine, Alder, Oak, Juniperus, Humulus. The pollen season is relatively short and the pollen dispersed mainly during the period from March to May in case of tree pollen, from April to September in case of grass pollen and from August to October in case of weed pollen. Total annual pollen count ranged from 36,412 grains/m3 (2002) to 1,342 grains/m3 (2006). The peak pollen season was seen for spring and autumn, especially in May and September during 1998.2012. In skin prick tests, birch was the highest sensitization rate (15.1%), followed by alder (14.7%), hazel (14.1%) in the tree for 15 years. And in weed, mugwort and ragweed were the highest sensitization rate (10.6%, 10.3%), followed by humulus (5.5%) for 15 years, but since 2008, was increased. Conclusion: Analysis of pollens sampled in the atmosphere of Busan, Korea, for a 15-year period identified 24 species of pollens with seasonal variation of some clinically important pollen load. Analysis of data, it showed that alder and birch are main allergen in spring for 15 years, and in 1998.2008, ragweed and artemisia was main allergen in fall, since 2009, followed by humulus. (Allergy Asthma Respir Dis 2014;2:38-47)

소아에서 마이코플라스마 폐렴과 바이러스 폐렴의 임상적 특징 비교: 다기관 단면연구

안세환 ( Se Hwan An ),조홍제 ( Hong Je Cho ),백혜성 ( Hey-sung Baek ),성명순 ( Myong Soon Sung ),윤정원 ( Jung Won Yoon ),최선희 ( Sun Hee Choi ),신윤호 ( Youn Ho Sheen ),한만용 ( Man Yong Han ) 대한천식알레르기학회(구 대한알레르기학회) 2018 Allergy Asthma & Respiratory Disease Vol.6 No.3

Purpose: This study was conducted to compare clinical features between Mycoplasma pneumonia and viral pneumonia. Methods: We retrospectively analyzed the medical records of 428 patients requiring hospitalization among children younger than 18 years of age in 5 hospitals in Seoul and Gyeonggi-do. There were 131 patients with M. pneumonia and virus coinfection, 167 patients with M. pneumonia without virus coinfection, and 130 patients with viral pneumonia. All subjects had radiographic evidence of pneumonia with specimens available for both M. pneumonia and viral testing. Virus was identified using the polymerase chain reaction assay in a nasopharyngeal or oropharyngeal swab. M. pneumoniae pneumonia was diagnosed serologically. Results: Human rhinovirus was detected in 60.3% (79 of 131) of children with M. pneumonia accompanied by virus coinfection. Respiratory syncytial virus (RSV) was detected in 38.2% (50 of 130) of children with viral pneumonia. The mean age was significantly lower in the viral pneumonia group than in the M. pneumonia group with and without virus coinfection. The sex distribution did not differ significantly among the 3 study groups. The procalcitonin level was higher in viral pneumonia and erythrocyte sedimentation rate level was higher in the M. pneumonia group although no significant difference was found in C-reactive protein level between the M. pneumonia and viral pneumonia groups. Conclusion: Clinical features and inflammatory markers between M. pneumonia and viral pneumonia may be useful for the treatment of community-acquired pneumonia. (Allergy Asthma Respir Dis 2018;6:155-160)

알레르겐 유무에 따른 아토피피부염 환아의 중증도와 혈중 25-hydroxyvitamin D3 농도와의 상관관계

황영진 ( Yong Jin Hwang ),최진욱 ( Jin Wook Choi ),김성원 ( Sung Woon Kim ),최광해 ( Kwang Hae Choi ),성명순 ( Myong Soon Sung ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.3

Purpose: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D3 levels and the severity of atopic dermatitis (AD), markers of atopy (total IgE, total eosinophil count, and eosinophil cationic protein) in AD children according to allergen sensitization. Methods: This cross-sectional study was carried out on 160 AD patients aged 1 to 18 years between March 2012 and August 2014. The AD patients (AD group) were subdivided into 2 categories according to the results of the allergic skin prick and Unicap tests: the allergic and nonallergic AD groups. We compared 25-hydroxyvitamin D3 levels between the AD and control groups. We also investigated relationships between serum 25-hydroxyvitamin D3 levels, the severity of AD, and markers of AD (total IgE, total eosinophil count, and eosinophil cationic protein) in the allergic and nonallergic AD groups. Results: The average 25-hydroxyvitamin D3 levels were 30.6±11.7 and 23.7±10.0 ng/mL, respectively, in the control and AD groups (P<0.001). The average 25-hydroxyvitamin D3 levels were 19.7±8.6 and 27.5±9.8 ng/mL, respectively, in the allergic and nonallergic AD groups, with clinical implications (P<0.001). The 25-hydroxyvitamin D3 levels were not significantly associated with SCORing Atopic Dermatitis index in the allergic (P=0.004, r=.0.092) or nonallergic (P=0.610, r=.0.58) AD groups. The 25-hydroxyvitamin D3 levels were not significantly associated with the aforementioned markers of atopy in the AD group. Conclusion: These results suggest that 25-hydroxyvitamin D3 may play a role in the pathogenesis of AD.(Allergy Asthma Respir Dis 2015;3:213-218)

호흡기 바이러스의 연령별, 성별, 계절별에 따른 유병률 변화: 단일기관에서 10년 동안 호흡기 질환으로 입원한 소아 환자를 중심으로

이승진 ( Seung Jin Lee ),이신혜 ( Shin Hae Lee ),하은교 ( Eun Kyo Ha ),신윤호 ( Youn Ho Sheen ),성명순 ( Myong Soon Sung ),정영호 ( Young-ho Jung ),이경석 ( Kyung Suk Lee ),지혜미 ( Hye Mi Jee ),한만용 ( Man Yong Han ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.6

Purpose: It is well known that respiratory viral infection has epidemiological characteristics, including season. This study aimed to investigate the patterns of the prevalence of common respiratory viruses during a period of 10 years with regard to age, sex, and season in Korean children. Methods: From June 2006 to November 2016, we obtained 11,798 specimens from patients aged less than 18 years who were admitted with lower respiratory infections. Ten respiratory viruses were detected using multiplex reverse transcription-polymerase chain reaction. Results: Of 11,798 specimens, at least 1 virus was detected in 4,845 (41.1%). Respiratory syncytial virus (RSV, 18.9%) was the most common virus detected, followed by human rhinovirus (HRV, 14.8%), adenovirus (9.5%), and human bocavirus (HBoV, 7.4%). The detection rate of HRV was higher in male subjects (male 60.0% vs. female 40.0%, P=0.004), but the other viruses had no significant differences with regard to sex. The subjects who were positive for RSV test were youngest (median, 10.5 months; interquartile range, 3.0-25.0 months), followed by human coronavirus (median, 13.0 months), HRV (median, 14 months), and parainfluenza (median, 14 months). HBoV was most commonly detected in spring (29.3%), enterovirus in summer (25.8%), HRV in fall (22.6%), and RSV in October and winter (22.6%). Conclusion: We found that the prevalence of respiratory viruses in Korean children during a period of 10 years was associated with age, sex, and season when the infection occurred. Further nationwide data is warranted to infer clinical implication of our results. (Allergy Asthma Respir Dis 2017;5:320-325)

심한 변비와 복부팽만으로 발견된 소아 크론병 1예

성명순,강석정,최광해 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Crohn's disease is a chronic inflammatory bowel disease that mainly affects children and young adults, Its cause remains unknown. The incidence of pediatric Crohn's disease is increasing, so it is important for clinicians to be aware of the presentation of this disease in the pediatric population The majority of patients complain of abdominal pain (72%), with only 25% Presenting with the 'classical triad' of abdominal pain, weight loss, and diarrhea. Many children with Crohn's disease present in a 'non-classical' manner, with vague complaints such as lethargy or anorexia, which may be associated with only mild abdominal discomfort Other symptoms include fever, nausea, vomiting, growth retardation, malnutrition, delayed Puberty, Psychiatric symptoms, arthropathy, and erythema nodosum. Severe constipation and abdominal distension are uncommon symptoms at diagnosis. We report a case of pediatric Crohn's disease, which was diagnosed after the patient presented with severe constipation and abdominal distension.

충수염으로 속발된 요관폐색증 1례

강석정,성명순,최광해 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Appendicitis is a common cause of acute abdomen in pediatrics. Periappendiceal abscesses are frequently found in the pediatric population. Acute appendicitis in children can, at times, be a difficult clinical diagnosis because of its highly variable history? and physical manifestations and its unpredictable course. Despite the uncertainty of the diagnosis, appendicitis demands prompt treatment because of the risk of perforation, which occurs in approximately one third of cases. Urological manifestations of appendicitis and appendiceal abscess can vary. Acute appendicitis presenting with ureteral stenosis and hydronephrosis is very rare. Here, we report a case of acute appendicitis with perforation and left hydronephrosis in a 3-year-o1d female. This case presents a 3-year-old girl with dysuria having hydronephrosis that originated from a perforated appendix.