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녹내장안에서 망막신경섬유층두께와 중심각막두께의 상관관계 분석
성경림,김동윤,남윤표,Kyung Rim Sung,Dong Yoon Kim,Yoon Pyo Nam 대한안과학회 2009 대한안과학회지 Vol.50 No.3
Purpose: To evaluate the correlation between central corneal thickness (CCT) and retinal nerve fiber layer thickness (RNFLT) as determined by optical coherence tomography (OCT) in glaucomatous subjects. Methods: One hundred eyes diagnosed with glaucoma and 99 glaucoma suspect (GS) eyes were tested by visual field (VF), OCT, and ultrasonic pachymetry. The relationship between CCT and RNFLT measurements was assessed by Pearson correlation analysis. A mixed effect model was employed to determine the relationship between CCT and RNFLT in glaucoma and GS groups. We divided the patients into two groups depending on the thickness of their corneas: Thin (< 553.6 μm) and thick (≥ 553.6 μm), and compared three parameters: VF mean deviation (MD), pattern standard deviation (PSD), and RNFLT between the two groups. Results: There were no significant correlations between CCT and RNFLT in any participant (R2=0.00, p=0.88). There was no significant relationship between CCT and RNFLT in glaucoma and GS groups (p=0.11, p=0.46). There were no statistically significant differences in MD, PSD, or RNFLT between the thin and thick cornea groups (p=0.38, 0.32, 0.44). Conclusions: CCT is not significantly associated with RNFLT in glaucoma and GS subjects.
Clinical Characteristics of Glaucomatous Subjects Treated with Refractive Corneal Ablation Surgery
성경림,이진영,김명준,나정화,김재용,차흥원 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.2
Purpose: To evaluate the clinical characteristics of newly diagnosed glaucomatous subjects who had a history of refractive corneal ablation surgery (RCAS). Methods: Sixty-eight glaucomatous subjects who had a history of RCAS and 68 age- and visual field (VF) mean deviation-matched glaucomatous subjects with no history of RCAS were included. Intraocular pressure (IOP), central corneal thickness (CCT), VF, and retinal nerve fiber layer thickness determined by optical coherence tomography were assessed. Parameters were compared between patients with and without a history of RCAS. Between-eye comparisons in the same participant (more advanced vs. less-advanced eye, in terms of glaucoma severity) were performed in the RCAS group. Results: With similar levels of glaucoma severity, those with a history of RCAS showed significantly lower baseline IOP and a thinner CCT than the eyes of individuals without a RCAS history (13.6 vs. 18.7 mmHg, 490.5 vs. 551.7 μm, all p < 0.001). However, the extent of IOP reduction after anti-glaucoma medication did not significantly differ between the two groups (17% vs. 24.3%, p = 0.144). In the between-eye comparisons of individual participants in the RCAS group, the more advanced eyes were more myopic than the less-advanced eyes (-1.84 vs. -0.58 diopter, p = 0.003). Conclusions: Eyes with a history of RCAS showed a similar level of IOP reduction as eyes without such a history after anti-glaucoma medication. Our finding that the more advanced eyes were more myopic than the less-advanced eyes in the same participant may suggest an association between glaucoma severity and myopic regression.
Assessment of Macular Ganglion Cell Loss Patterns in Neurologic Lesions That Mimic Glaucoma
손길환,성경림 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.4
Purpose: To evaluate patterns of macular retinal ganglion cell (RGC) loss measured by spectral domain opticalcoherence tomography in patients with neurologic lesions mimicking glaucoma. Methods: We evaluated four patients with neurological lesions who showed characteristic patterns of RGC loss,as determined by ganglion cell thickness (GCT) mapping. Results: Case 1 was a 30-year-old man who had been treated with glaucoma medication. A left homonymousvertical pattern of RGC loss was observed in his GCT map and a past brain magnetic resonance imaging (MRI)revealed a hemorrhagic lesion around the right optic radiation. Case 2 was a 72-year-old man with a pituitaryadenoma who had a binasal vertical pattern of RGC loss that corresponded with bitemporal hemianopsia. Case 3 was a 77-year-old man treated for suspected glaucoma. His GCT map showed a right inferior quadraticpattern of loss, indicating a right superior homonymous quadranopsia in his visual field (VF). His brain MRIrevealed a left posterior cerebral artery territory infarct. Case 4 was a 38-year-old woman with an unreliableVF who was referred for suspected glaucoma. Her GCT map revealed a left homonymous vertical pattern ofRGC loss, which may have been related to a previous head trauma. Conclusions: Evaluation of the patterns of macular RGC loss may be helpful in the differential diagnosis ofRGC-related diseases, including glaucoma and neurologic lesions. When a patient’s VF is unavailable, thismethod may be an effective tool for diagnosing and monitoring transneuronal retrograde degeneration-relatedstructural changes.
이진영,성경림,나정화,이영록,Jin Young Lee,MD,Kyung Rim Sung,MD,PhD,Jung Hwa Na,MD,Youngrok Lee,MD 대한안과학회 2012 대한안과학회지 Vol.53 No.5
Purpose: To evaluate the use of prophylactic antibiotics in glaucoma surgery and the prevalence of postoperative endophthalmitis. Methods: Retrospective medical record review was performed on 136 eyes which underwent glaucoma operation by one surgeon from March 2008 to February 2010 and were followed at least till 6 months postoperatively (glaucoma drainage device implantation; 95 eyes, trabeculectomy; 41 eyes). Results: For intravenous antibiotics injection, 10 eyes used 3rd generation cephalosporin, 54 eyes used 4-fluoroquinolone, 72 eyes used 2nd generation cephalosporin. For oral antibiotics, 125 eyes used 3rd generation cephalosporin, 1 case used 4-fluoroquinolone, and other 10 cases did not use oral antibiotics after the surgery. Total period of systemic antibiotics use showed various distributions with 14 eyes more than 5 days, 115 eyes 4-5 days, and 8 cases less than 4 days. Six eye which used 4-fluoroquinolone and 3 eyes which used cephalosporin showed side effect such as skin lesion and nausea. There has been no single occurrence of endophthalmitis. Conclusions: Various kinds of prophylactic antibiotics were used for glaucoma surgery and the period of antibiotics use was different among patients. However, there has been no single occurrence of endophthalmitis till 6 months postoperative follow up. J Korean Ophthalmol Soc 2012;53(5):647-651