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Methamphetamine 이 면역장기 및 항체생성능에 미치는 영향
선우연(Woo Yearn Sun),한형미(Hyung Mee Han),윤은이(Eun Yi Yoon),신전수(Jeon Soo Shin),박현애(Hyeon Ae Park),김미영(Mi Young Kim) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.1
BALB/c mice were intraperitoneally injected with methamphetamine (5 mg/kg) to observe the effect of methamphetamine on the immune system. Body weights were decreased in both acutely treated group (twice for 2 weeks with 7 days interval) and subchronically treated group (daily injection for 14 days). The relative spleen weights and the numbers of splenocytes were unexpectedly increased (p<0.05) in acutely treated group, but subchronically treated group showed the trend of decrease without significance. But there was no significant effect on antibody formation to hen egg lysozyme which was immunized during the treatment of methamphetamine and on plaque forming cell number. The relative thymus weights of both groups were significantly decreased by the treatment of methamphetamine (acutely treated group, p<0.05; subchronically treated group, p<0.01). These results suggest that the effect of methamphetamine on the immune system may be caused by thymic dysfunction.
기니픽과 마우스에서 CFC-101 ( 녹농균 백신 ) 의 항원성시험
선우연(Woo Yearn Sun),한형미(Hyung Mee Han),김현수(Hyun Su Kim),백남진(Nam Jin Baek),김달현(Dal Hyun Kim),이동억(Dong Eok Lee),정승태(Seung Tae Chung),김필선(Pil Sun Kim) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
As a part of the safety evaluation of Pseudomonas vaccine(CFC-101), antigenicity tests were carried out in guinea pigs and mice. In active systemic anaphylaxis(ASA) test, guinea pigs showed no sign or only moderate sign(1/5) when sensitized and challenged with up to 200 ㎍/㎏. In homologous passive cutaneous anaphylaxis(PCA) test using guinea pigs, inoculation of CFC-101 alone did not produce CFC-101-specific antibody. When inoculated with 200 ㎍/㎏ plus adjuvant, challenge of 200 ㎍/㎏ produced PCA titer of 32(5/5) but challenge of 20 ㎍/㎏ did not produce CFC-101-specific antibody. In heterologous PCA test using mice, CFC-101-specific antibody was not detected when sensitized with CFC-101 alone. Some animals(3/12) showed positive PCA response when inoculated with 200 ㎍/㎏ plus alum. In passive hemagglutination (PHA) test, although no antibody was detected at 20 ㎍/㎏, inoculation of 200 ㎍/㎏ alone or with alum produced positive response in all animals. This result has already been predicted because CFC-101 is a vaccine developed for the purpose of immunization. From the above results, it can be concluded that there is no adverse antigenic potential up to 10 times clinical dose of 200 ㎍/㎏.
Methamphetamine 이 B16 악성 흑색종 세포 전이에 미치는 영향
선우연(Woo Yearn Sun),한형미(Hyung Mee Han),신전수(Jeon Soo Shin),박현애(Hyeon Ae Park),정승태(Seung Tae Chung),김필선(Pil Sun Kim),손경희(Kyung Hee Sohn) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.4
The effect of methamphetamine on the pulmonary metastasis was investigated in C57BL/6 mice injected with B16 melanoma cells. B16 melanoma cells (2x10^5 cells) were injected intravenously into 5∼7 weeks old C57BL/6 mice. Mice were then treated intraperitoneally with methamphetamine either acutely (two times with one week interval) or subchronically (daily for 14 days). Degree of pulmonary metastasis was investigated and specific immunologic parameters such as natural killer cell cytotoxicity(NKCC), antibody-dependent cellular cytotoxicity(ADCC) and blastogenic responses of splenocytes were examined. Mice which had been subchronically treated with methamphetamine showed significant decreases in the number of pulmonary metastasis of B16 melanoma cells, NKCC and ADCC without a significant change in blastogenic responses. In the acutely-treated group, slight trends of decrease in the numbers of pulmonary metastasis, NKCC and ADCC were observed without statistical significances whereas there was a significant increase in blastogenic responses. The mechanism underlying the decrease in the degree of metastasis despite diminished NKCC and ADCC after methamphetamine treatment and the relationship between the degree of pulmonary metastasis and duration of methamphetamine treatment remain to be investigated.
수은이 시험관내 사람 다형핵백혈구의 기능에 미치는 영향
김효정,한형미,김순한,김옥연,선우연,윤은이 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
In the present study, the effect of HgCl₂ on the function of human peripheral polymorphonuclear leukocytes(PMNs) was examined. PMNs were isolated from human peripheral blood with density centrifugation in Ficoll-Paque. The cells were then incubated with 0.5∼5 μM HgCl₂ and glass adherence, chemotactic activity and erythrocyte-antibody rosette forming activity were measured. HgCl₂ decreased the function of PMNs in all three aspects tested. HgCl₂ significantly diminished glass adherence(0.5 μM: 92±12% (percentage of control, mean±S.D.); 1μM: 46±11%, P<0.01; 3 μM: 35±7%, P<0.01; 5 μM: 49±10%, P<0.01). Similarly, significant differences were observed in chemotactic activity after HgCl₂ treatment compared with control (control: 0.95±0.14 mm; 0.5μM: 0.91±0.11 mm; 1μM: 0.77±0.16 mm, P<0.05; 3μM: 0.61±0.06 mm, P<0.01; 5μM: 0.15±0.03 mm, P<0.01). Also, HgCl₂ decreased the percentage of rosette-forming PMNs, indicating diminished phagocytic activity of PMNs upon HgCl₂ exposure compared with control (control: 58±4%; 1 μM: 53±4%, P<0.05; 3 μM: 49±3%, P<0.01; 5 μM: 46±3%, P<0.01). Cell viability was not altered after HgCl₂ treatment (83±5% viability in control PMNs versus 81±8% viability in 5 μM HgCl₂-treated PMNs), suggesting that the impaired PMN function after HgCl₂ treatment was not due to nonspecific cytotoxicity induced by HgCl₂. HgCl₂-induced decrease in the function of PMNs may have some implications in depressed host susceptibilityupon bacterial challenge after mercury exposure.