피부 및 내장에 전형적 소견을 보인 악성 위축성 구진증 1 예

서기범(Ki Beom Suhr),이증훈(Jeung Hoon Lee),박장규(Jang Kyu Park),김정수(Jeong Soo Kim),김경호(Kyung Ho Kim),박민수(Min Su Park),송인상(In Sang Song) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.1

A 33-year-old male patient had malignant atrophic papulosis that affected the skin and intestinal tract and probably respiratory system. He had multiple typical skin lesion with porcelain-white atrophic scars on the whole body surface area except on face, palm and sole. And he had been operated two times due to intestinal perforation after onset. Multiple whitish necrotic patches were found in small and large intestine during laparotomy. Also he had a plueral effusion. Histopathologic studies showed atrophic epidermis and dermal necrosis, vascular change, mucin deposition in lower dermis. He was treated with acetyl salicylic acid and dipyridamole, but there was no improve-ment. He died of intestinal perforation and respiratory failure 67 months after onset(6 months after onset of abdominal symptom). (Korean J Dermatol 2002;40(1):48~53)

흡입수포액 및 냉동수포액이 섬유아세포 성장에 미치는 영향에 관한 연구

서기범(Ki Beom Suhr),김경훈(Kyung Hoon Kim),이우재(Woo Jae Lee),박장규(Jang Kyu Park) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.1

Beckground : Wound fluid is believed to contain growth factors produced by cells involved in the healing process. One of the beneficial effect of occlusived ressing is the retention of released fluid from the wound, which is thought ta accelerate wound healing. However, there was no report how suction-induced or cryoinduced bulla flicmight affect the healing of the wound itself. Objective : Therefore, we have examined the effect of sucior-or cryo-induced bulla fluids on the in vitro growth of buman dermal fibroblasts. Methods : Suction-or cryo-indueed bulla fluid were sterilel cillected from the suction blisters and cryotherapy induced bulla, respectively. After seed n in optimal growth media on day 0, cultures of normal fibroblasts were supplemented with various concentrations of human serum, suction-indaiced bulla fluid, and cryoinduced bull fiuid on day 2, 4, 6, 7 or 8. Results : As determined by cell counts or H-thymidine inorioration, the effect of human serum were much more than those of suction-induced bulla flazic on the growth of fibroblasts. Although slight mitogenic effects were observed in the case of 5 year yoinduced bulla fluid, 10 % cryoinduced bulla fluid inhibited the growth of the fibroblest, as well. Conclusion : These results suggested that suction-induced ulla fluid was not a whole human serum but a dilutet serous material having limited stipulated effect to the growth of the fibroblasts, and cryoinduced bulla held the unknown in laboratory or toxic factors as well. (Kor J Dermstol 1995; 33(l): 85-91)

Clinical Performance Enhancing Program 5 (CPEP 5) : Treatment of atopic dermatitis caused by non-immunological food intolerance

서기범 ( Ki Beom Suhr ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Clinical Performance Enhancing Program 1-6 (CPEP 1-6) : How to manage severe or recalcitrant atopic dermatitis patients in the clinics

서기범 ( Ki Beom Suhr ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Atopic dermatitis (AD) is a common, multifactorial inflammatory skin disease with a profoundnegative impact on quality of life of patients and their families. The management of severe or recalcitrant atopic dermatitis (AD) is a challenging issue for clinicians and patients. So far, first-line treatments of AD have been known as topical steroids and topical calcineurin inhibitors, treatment with ultraviolet (UV) radiation and oral antibiotics. Second-line therapy includesimmunosuppressive drugs, such as azathioprine, cyclosporine, systemic prednisolone, or methotrexate. In some patients the disease takes a severe chronic course recalcitrant to these traditional first- and second-line therapies. In such cases, unconventional and less standardized third-line treatment regimes may be sought in order to ameliorate the disease effectively. But, it is not easy to prescribe some complicate methods in the skin clinics. I will introduce some methods how to manage severe or recalcitrant AD in my clinic. In the erythrodermic AD, cyclosporine and specific Immunotherapy with injection or oral administration are most frequent choice. Nummular eczema like AD has some difficulty to becontrolled by medical administration, or is strongly resistant to topical potent corticosteroids. Excimer laser therapy is first choice for the thick nummular AD in my clinic. Simultaneously, food elimination therapy is following after food IgG4 blood test. Management of leaky gut syndrome with leaky skin is doing with broad-spectrum antibiotics, probiotics, omega-3, vitamin D, and zinc. Wet-wrap dressing is another choice.

헬륨 - 네온 레이저 조사가 단층 ( monolayer ) 과 교원질 격자 ( Collagen lattice ) 에 배양한 인체 섬유모세포의 증식과 교원질 합성에 미치는 영향

서기범,윤소영,이우재,이증훈,박장규 (Ki Beom Suhr,So Young Yoon,Woo Jae Lee,Jeung Hoon Lee,Jang Kyu Park) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

Background: Recently it has been suggested that lasers can modulate the biological functions of cells in vitro. It has also been reported that a helium-neon(He-Ne) laser can stimulate wound healing in the absence of thermal effects. However, the results of more recent studies on the influence of He-Ne laser irradiation on the proliferation and collagen synthesis of human dermal fibroblasts have been inconclusive. And most experiments have not been performed in a three-dimensional collagen lattice that is the physiologic model for an in vitro experiment. Objective : In this study we have investigated the nature of the influence of He-Ne laser irradiation on the proliferatior and collagen synthesis of human dermal fibroblasts cultured in a monolayer and collagen lattice. Methods : We used a 10mW He-Ne laser emitting a beam of wavelength 632,8nm. The human dermal fibroblasts were subjected to laser treatment at various energy densities, and the treatment schedule included one daily exposure on three consecutive days. DNA replication was assessed by H-thymidine incorporation, and the collagen production was monitored by the synthesis of H-hydroxyproline following incubation of the culture with H-proline. Results : The results were as follows : In the control group, the proliferation and collagen synthesis of fibroblasts sultured in a collagen lattice on day 4 and 7 were significantly reduced compared with conventional manolayer cultures. Although the proliferation of human dermal fibroblasts was not remarkable in all experimental irradiation energy except 4 J/cm in a monolayer culture, a statistically significant stimulating effect on fibroblasts proliferation in collagen lattice were noted on days 4 and 7 with an energy density of 1.5J/cm. And we also found that a great er increase of collagen synthesis of human dermal fibroblasts occurred in a monolayer culture on days 4 and 7 in all irradiated energy densities than those in a collagen lattice culture. But statistically significant enhancement of collagen synthesis was showed only at the energy density of 1 J/cm in a collagen lattice culture on days 4. Conclusion : These data indicated that the influence of He-Ne laser irradiation on the proliferation and collagen synthesis of human dermal fibroblasts cultured in a collagen lattice was remark ably different from those in a monolayer culture. In the clinical application of the He-Ne laser, the control of the amount of irradiation of the He Ne laser may regulate the proliferative activity and collagen synthesis of human dermal fibroblasts in wound healing. (Kor J Dermatol 1996;34(2): 279-288)

섬모기질종 25예의 임상 및 병리조직학적 연구

서기범,이우재,윤지석,이증훈,박장규 ( Ki Beom Suhr,Woo Jae Lee,Ji Seog Yoon,Jeung Hoon Lee,Jang Kyu Park ) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.1

투명세포 한선종 2예

노영우,김경훈,서기범,박장규 (Young Woo Ro,Kyung Hoon Kim,Ki Beom Suhr,Jang Kyu Park) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

We report here two cases of clear cell hidradenoma. The first patient was a 19-year-old adolescent, who had single, pinkish, nodule on the left cheek for 1 year. The second case of 70-year-old woman had multiple projecting, pinkish tumor mass with serous discharge on the right inframammary area for 20 years. On histopathological examination, we could observe polyhedral cells and clear cells with tubular differentiation in both cases and large cystic changes due to tumoral degeneration in the second case, The tumor masses were excised, and have not recurred. (Kor J Dermatol 1996;34(2): 300-303)

충청 지방에서 발생한 Trichophyton verrucosum에 의한 두부 독창

노영우,이우재,서기범,이증훈,박장규 ( Young Woo Ro,Woo Jae Lee,Ki Beom Suhr,Jeong Hoon Lee,Jang Kyu Park ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

In Korea, Kerion celsi caused by T. verrucosum was first reported by Kim et al in the Honam province in 1986. Since then three mare cases have been reported in the Young Nam province. Herein present a case of kerion celsi caused by T. verrucosum from Chungcheong province. The patient, a 7-year old female, showed a 4x 4cm sized, oval, yellow crusted and boggy patch with alopecia on the scalp. She was living on a farm in a rural area of Chungcheong province. Cows on the farm also exhibited similar skin lesions on the buttock. The same T. verrucosum was identified by a characteristic colony morphology on Sabourauds dextrose agar and chains of chlamydoconidia with mycologic stain from scales of lesions of patient and cows. This skin lesion was successfully treated with griseofulvin. (Kor J Dermatol 1997;35(1): 187~190)

피부 편평세포암의 임상 및 병리조직학적 관찰

김윤동(Yoon Dong Kim),서기범(Ki Beom Suhr),이증훈(Jeung Hoon Lee),박장규(Jang Kyu Park) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.1

N/A Background:The cutaneous squamous cell carcinoma(SCC) is a malignant proliferation of the keratinocyte of the epidermis. It may have the potential to metastasize distally in contrast to the cutaneous basal cell carcinoma (BCC). Our lives were being lengthened gradually and our society was being polluted by many causative factors. Because many kinds of cutaneous malignant tumors occurred to the aged and resulted from the severe pollution, a lot of people have been interested in SCC. Objective:In this study we investigated the recent trend of the cutaneous squamous cell carcinoma in clinical and histopathological aspects. Methods:Seventy one cases of SCC who had visited the Department of Dermatology, Chungnam University Hospital during the last 17 years(between 1983 and 1999) were confirmed in histopathological review. The observation of occurrence rate in years, age and sex distribution, onset, site, cause, histopathological malignancy and treatment was done, retrospectively. Results:1. The occurrence of the cutaneous squamous cell carcinoma in males was one and half times more than in females(M>F:1.63x). Age distribution showed almost above 60 years old(about 74%). 2. The common sites (in decreasing order) were face(56%), extremities(upper>lower), other sites and most etiologic factors were idiopathic(71%), in 2cases metastatic. 3. Histopathologically, the subtype of SCC was verrucous(7%), acantholytic(10%), spindle cell(6%), and the degree of differentiation was well-, moderate-, poor-differentiated (respectively 25%, 32%, 20%), and SCC invaded to full dermis(84%) and subcutis(9%). 4.Various treatments were done and among them the simple excision(53%) was common. 5.case recurred and four cases metastasized to adjacent lymph node. One case expired. Conclusion:We investigated the recent trend of the cutaneous squamous cell carcinoma through our cases of SCC who had visited the department of dermatology, chungnam university hospital. (Korean J Dermatol 2002;40(1):25~30)

상대정맥 증후군

윤소영 ( So Yeong Yoon ),김경훈 ( Kyung Hoon Kim ),서기범 ( Ki Beom Suhr ),박장규 ( Jang Kyu Park ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

The superior vena cava syndrome can occur when an extrnsc compression or intralurninal occlusion impedes blocxl flow through this vessel. We report a case of superior vena cava syndrome with tirc nbophlebitis on the right forearm in 57 year old male patient who used steroids (p.o) for 25 years. (Kor J Dermatol 1995;33(3): 570-574)