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천연약제 Momordin의 구강암(KB) 세포주에 대한 항암작용기전에 관한 연구
서경성,김여갑,Seo, Kyeong-Seong,Kim, Yeo-Gab 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.3
Treatment of oral cancers with chemotherapeutic agents are evaluated as an effective method for remission to reduce cancer proliferation nowadays. But, minimization of side-effects such as bone marrow suppression, gastrointestinal toxicity and renal damage is another problem to be solved. Thus, a possible approach to develop a clinically applicable chemotherapeutic agents is to screen anticancer activity among traditional medicinal plants which have been used for thousands of years with very low side-effects in orient. In this study we focused on anti-oral cancer activities of momordin, which was medicinal plant extracts that was revealed anticancer activities, on KB cell(oral cancer cell). The results were as follow : 1. Momordin showed the excellent anti-oral cancer activity against KB cells. Obtained IC50 value of Momordin was $10.4{\mu}g/ml$. 2. When KB cells were treated with Momordin, dose and time dependent DNA fragmentation of KB cells were observed. DNA fragmentation was initiated on three days at the concentration of $20{\mu}g/ml$ Momordin. 3. Flow cytometry showed dose-dependent apoptotic cell increase of KB cells on Momordin. 18.55% apoptotic cell were observed up to 72 hours at the concentration of $20{\mu}g/ml$ of Momordin. 4. Momordin induced nonspecific apoptosis without specific cell cycle arrest. 5. Through MTT assay, DNA fragmentation assay and flow cytometric analysis. anticancer effect of Momordin against KB cell was induce of apoptotic cell death.
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하순에 발생한 우췌성상피세포암의 Karapandzic flap을 이용한 치험례
서경성,류동목,이상철,김여갑,이백수 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6
The verrucous carcinoma which was classified by Ackerman in 1948 is generally well differentiated and slow growing. After its radical surgery, it is rarely recurrent of carcinoma. Tobacco chewing is a most important factor in the etiology of these lesion. It frequently affect males over 55 year old age and usually appears on buccal and mandibular alveolar mucosa. The continuing effort by plastic surgeon to reconstruc lips successfully has been accompanied by numerous publications on the subject. More recent communications have dealt with modifications or refinements of existing procedures. In 1974, Karapandzic reported the use of arterialied flaps to reconstruct lips following excisions of cancers. We have treated 65 year old male patient rapid growing verrucous carcinoma on lower lip with Karapandzic flap. Postoperatively the results showed good prognosis. So we report the result of its treatment and case with review of literature.
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