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갑상선 유두암에서의 bcl-2와 P53 단백질 발현의 의의
지웅배,배정원,우상욱,손길수,이재복,구범환,채양석<SUP>1<,SUP>,Woong Bae Ji,M,D,Jeoung Won Bae,M,D,Sang Uk Woo,M,D,Gil Soo Son,M,D,Jae Bok Lee,M,D,Bum Whan Koo,M,D,and Yang-Seok Chae,M,D,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2007 The Koreran journal of Endocrine Surgery Vol.7 No.4
Purpose: Papillary thyroid cancer (PTC) has a good prognosis, and it's known to be related to the apoptosis of papillary thyroid cancer. The expression of bcl-2 is thought to be associated with the inhibition of apoptosis. We evaluated the differences of bcl-2 and P53 between PTC and the control (normal tissue and benign lesion). We then analyzed the correlation between the bcl-2 and P53 expressions and the classic prognostic factors. Methods: Between January 2001 and December 2005, 30 patients who underwent total thyroidectomy for the PTC were included in this study and immunohistochemical staining was performed on the tumors. Results: bcl-2 was expressed in 18 cases (60%) in their PTC (P<0.05). The expression of P53 was not significantly related with the clinicopathological factors, but P53 was expressed in 9 cases (30%) of PTC (P<0.05). The positive staining for was noted in 18 cases (62.1%) of the PTC tissue among the 30 patients, and as the TNM stage progresses, the expression rate of was significantly decrease for 7 stage I cases (100%), for 4 stage ll cases (80%) and for 7 stage ll cases (38.9%). Conclusion: bcl-2 was expressed more as the TNM stage of PTC decreases. So bcl-2 is possibly useful as a prognostic factor for PTC, but further studies are needed for confirming its significance. (Korean J Endocrine Surg 2007; 7:231-236)
만성신부전증환자에서 부갑상선 절제술 시 수술 중 급속 부갑상선 호르몬 측정의 의의
김우영,손길수,배정원,구범환,이재복,Woo Young Kim,M,D,Gil Soo Son,M,D,Jeoung Won Bae,M,D,Bum Hwan Koo,M,D,and Jae Bok Lee,M,D 대한갑상선-내분비외과학회 2005 The Koreran journal of Endocrine Surgery Vol.5 No.2
Purpose: Intraoperative quick parathyroid hormone assay (PTH) was introduced in the parathyroid surgery since 1988 and the value in patients with primary hyperparathyroidism was well recognized in the literature. The purpose of this study was to evaluate the usefulness of intraoperative rapid PTH assay in patients with renal hyperparathyroidism by comparing intraoperative PTH results and the biochemical results at postoperative 6<SUP>th</SUP> month, including PTH values. Methods: Fifteen consecutive patients of renal hyperpara</SUP>thyroidism underwent total parathyroidectomy and immediate autotransplantation from November 2003 to February 2005. PTH levels were measured by PTH assay at the induction of anesthesia (baseline level) and in 20-minute intervals after excision of the last parathyroid gland. More than 50% drop of initial PTH level was considered as completeness of parathyroidectomy. Results: Twenty minutes after resection, PTH levels decreased by 83.7% in 14 patients and by 50.2% in one patient. Ten patients (67%) were cured but 5 patients (34%) showed high PTH levels after 6 months. The drop rate of intraoperative quick PTH level in cured patients was 92% at 26 minutes after parathyroidectomy and was significantly different from 73.3% of persistent or recurrent five patients (P=0.047). Preoperative PTH level, calcium level, alkaline phosphatase level and preoperative localization were not different in the cured and recurrent or persistent patients of renal hyperparathyroidism. Conclusion: The value of intraoperative quick PTH assayin patients of renal hyperparathyroidism was questionable. More than 92% drop of intraoperative PTH level at 26 minutes after parathyroidectomy could predict success in our study. (Korean J Endocrine Surg 2005;5:93-99)
갑상선 결절 환자에서 혈청 갑상선자극호르몬 수치와 고분화 갑상선암과의 연관성에 관한 분석
정성엽,김훈엽,류우상,우상욱,손길수,이재복,배정원,Sung Yup Joung,Hoon Yub Kim,Woo Sang Ryu,Sang Uk Woo,Gil Soo Son,Jae Bok Lee and Jeoung Won Bae 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4
Purpose: This study investigated the effects of serum thyroid-stimulating hormone (TSH) levels in predicting malignancy-associated differentiated thyroid cancer (DTC) and benign thyroid nodules. Methods: Between January 2005 and December 2007, 346 patients underwent thyroid surgery at one hospital. Their records were retrospectively reviewed. Results: Sixty-nine percent (237 of 346) of the patients had DTC. The mean preoperative TSH level was higher than in the malignant group (5 uIU/ml vs 0.4 uIU/ml). The rate of malignancy was the 71% in patients with TSH levels >5 uIU/ml. The TSH level of DTC with metastasis of the lymph node was higher than that with non-metastasis (3.08 uIU/ml vs 2.09 uIU/ml, P<0.01) Conclusion: The likelihood of DTC increases with higher serum TSH concentration. Serum TSH level might be useful in predicting malignant nodular thyroid lesion. (Korean J Endocrine Surg 2010;10:220-223)
유지영 ( Ji Young You ),이혜윤 ( Hye Yoon Lee ),이은숙 ( Eun Sook Lee ),배정원 ( Jeoung Won Bae ),우상욱 ( Sang Uk Woo ),박경화 ( Kyong Hwa Park ) 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2
배경: 삼중음성유방암은 비삼중음성유방암군에 비해 조기라 해도 더 나쁜 예후를 보이는 걸로 알려져 있다. 따라서 삼중음성유방암의 초기 치료를 위해서 정확한 예후인자를 찾는 것이 중요하다. 본 연구에서는, T1-2 림프절 음성인 삼중음성유방암의 나쁜 예후와 관련된 예후인자를 찾아 보고자 하였다. 방법: 1995년부터 2006년까지 고려대학교 의료원 안암병원에서 유방암으로 근치절제술을 시행받은 환자 중 림프절 전이나 원격전이가 없는 환자를 대상으로 하였다. 이 중에서 호르몬 수용체 및 HER2 수용체 여부에 대한 기록이 있는 환자들만을 포함시켰다. 의무기록의 후향적 분석을 통해 삼중음성유방암 및 비삼중음성유방암 환자들의 임상병리적 특징이 분석되었다. 결과: 79명 (22.9%) 의 환자들이 삼중음성유방암군으로 분류되었다. 삼중음성유방암군에서 p53 양성 환자군에서 p53 음성 환자군보다 더 낮은 무병생존율을 보였다 (p=0.028). 다변량 회귀분석에서는 35세 이하의 낮은 연령이 삼중음성유방암과 관련된 독립적인 예후인자로 나타났으며, Ki-67은 단변량 회귀분석에서 삼중음성유방암과 통계적으로 유의하게 관련성을 보였다. 결론: 본 연구에서, T1-2 림프절 음성인 삼중음성유방암에서 연령은 독립적인 예후인자이고 어릴수록 나쁜 예후와 연관됨을 알 수 있었고, Ki-67 은 통계적으로 증명되지는 않았지만, 삼중음성유방암의 예후인자가 될 수 있을 것으로 생각된다. Purpose Triple-negative breast cancer typically results in poorer prognoses compared to non-triple negative breast cancer, even in early stages. The initial management of triple negative breast cancer patients and detection of clear prognostic factors are therefore of great importance. We aimed to identify specific prognostic factors associated with unfavorable outcomes of triple negative breast cancer in T1-2 node-negative breast cancer. Materials and Methods We analyzed breast cancer patients without lymph node metastasis or distant metastasis who underwent curative surgery at the Anam Hospital of the Korea University Medical Center between 1995 and 2006. Among them, patients were eligible for analysis, only if the reports about hormone receptor and human epidermal growth factor receptor-2 status were available. Clinico-pathological features were reviewed by retrospective examination and comparison of medical records of triple negative breast cancer and non-triple negative breast cancer patients. Results Seventy-nine patients (22.9%) were categorized to the triple negative breast cancer group. The disease-free survival rate of TNBC p53-positive patients was significantly lower than that of p53-negative patients (p =0.028). In multivariate analysis, young age was an independent prognostic factor for disease-free survival of the triple negative breast cancer group. High Ki-67 expression was a significant prognostic factor in univariate analysis in triple negative breast cancer, but it was not significant in multivariate analysis. Conclusion We suggest that age is an independent prognostic factor of triple negative breast cancer in T1-2 and node-negative patients and that Ki-67 could also be a prognostic factor in these patients.