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RISS 인기검색어
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- 저자 : 박진생(Jin Seng Park) (검색결과 3 건)
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Haloperidol의 약물속도론적 연구 (III) -정신분열증 환자에 있어서 Haloperidol의 일회 주사 및 경구투여시의 Pharmacokinetics-
박경호(Kyoung Ho Park),이민화(Min Hwa Lee),이명걸(Myung Gull Lee),권준수(Jun Soo Kwon),박원명(Won Myung Park),박진생(Jin Seng Park) 대한약학회 1990 약학회지 Vol.34 No.6
The pharmacokinetics of haloperidol were determined after single oral and intravenous doses in 13 male schizophrenic patients. Plasma concentrations of haloperidol(HP) and reduced haloperidol were measured by high performance liquid chromatography. Plasma concentration data obtained were analyzed by obth model dependent (one-or two exponential decay models using nonlinear regression) and model independent (AUC and first moment curve) approaches. The two methods were found to be in close results. After intravenous injections of HP in 8 patients (10 mg/man), the mean central and peripheral volume of distribution were 2.85+/-1.7O and 8.09+/-2.10 l/kg, respectively, and mean steady, state volume of distribution was 11.87+/-3.21 l/kg. Mean clearance, MRT and elimination half life were 12.39+/-3.25 ml/min/kg, 925.1O+/-166.79 min and 676.35+/-126.45 min,respectively. After oral administrations of HP in 5 patients, mean peak time and peak concentration were 2l7.63+/-61.60min and 9.77+/-2.92ng/ml, respectively. Mean MRT and elimination half life were 1112.23+/-131.73 min and 724.02+/-120.03 min, respectively, and these parameters were not significantly different from those of intravenous injection of HP. Absolute bioavailability of HP oral product was found to be about 44%. The profiles of plasma RH concentration-time curves after oral or intravenous doses of HP were similar. Also it was found that the elimination rate of RH was slower than that of HP by comparing the slopes of plasma concentration-time curves of HP and RH.
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박진생,김명정 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.2
우울증을 동통증상의 유무별로 나누어 양군 간에 증후학적인 차이점을 검증해 보기 위하여 DSM - Ⅲ 진단기준에 의거하여 주요우울증으로 진단된 40명 중, 유동통우울증 22명과 무동통우울증 18명을 대상으로 하여 평가한 HRSD를 자료로 삼아 양군 간에 증후학적 차이를 검증하여 다음과 같은 결과를 얻었다. 1) 양군 간에 HRSD의 각 증상항목별 차이를 t-검증산 결과 유동통우울증은 무동통우울증에 비하여, 자살, 초조, 정신적 불안, 신체적 불안, 일반적 신체증상, 건강염려증이 유의하게 심했고, 반면 지체는 유의하게 적었다. 2) 요인분석결과 나타난 6개의 요인 중 요인 1 즉, 초조, 정신적 불안, 신체적 불안, 일반적 신체증상 및 지체(음)와 요인 2 즉, 자살, 우울기분, 위장관 증상의 아군별 요인점수는 유동통우울증에서 유의하게 높았다. 이사의 결과에서 저자는 유동통우울증과 무동통우울증 간에 증후학적 차이가 있다는 하나의 증거를 관찰하고 우울증을 동통유무 별로 분류해 볼 수 있는 가능성이 있음을 시사받았다. In order to examine symptomatological difference between depression with pain symptoms and depression without pain symptoms, 40 subjects with the DSM-Ⅲ diagnosis of major depression were rated for their symptoms using HRS-D and 22 depressives with pain and 18 depressives without pain were compared for the rated symptomatology. The result were as follows; 1) A t-test for each symptom items of HRS-D comparing between the two groups revealed that the depressives with pain had higher rations of suicide, agitation, psychic anxiety, somatic anxiety, general somatic symptoms and hypochondriasis but lower rating of retardation. 2) Out of six factors derived from factor analysis, factor 1 composed of agitation, psychic anxiety, somatic anxiety, general somatic symptoms and retardation (negative saturation) and factor 2 of suicide, depressed mood and gastrointestinal somatic symptoms had significantly higher factor scores in the depressives with pain than in those without pain. From these results, the author suggests that some symptomatological difference exists between depression with pain and depression without pain, thus supporting a ground for a new possible classification of depression.
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