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유성연,주병수,이상윤,박종학,Yu, Seong-Yeon,Ju, Byeong-Su,Lee, Sang-Yun,Park, Jong-Hak 대한기계학회 1997 大韓機械學會論文集B Vol.21 No.8
Effect of vortex generator on the heat transfer enhancement of electronic chips is investigated using naphthalene sublimation technique. Experiments are performed for a single chip and chip arrays, and shape of vortex generator, position of vortex generator, stream wise chip spacing and air velocity are varied. Local and average heat transfer coefficients are measured on the top surface of simulated electronic chips, and compared with those obtained without vortex generator. In case of a single chip, heat transfer augmentation is seen only on the upstream portion of chip surface, while heat transfer enhancement is found on the whole surface for chip arrays. Rectangular wing type vortex generator is found to be more effective than delta wing.
김상현 ( Sang Hyun Kim ),김현정 ( Hyun Jung Kim ),김민희 ( Min Hee Kim ),박원도 ( Won Do Park ),한성훈 ( Seong Hoon Han ),유성인 ( Sung In Yu ),장효정 ( Hyojeong Chang ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
A 59-year-old man visited our hospital for facial edema and muscle weakness in both lower extremities. He was diagnosed with dermatomyositis (DM) about 1 year previously, and sudden development of proteinuria was noted. Renal biopsy revealed focal global and segmental glomerulosclerosis with slight mesangial expansion. Glomerulonephritis is rare in DM. According to our review of related literature, membranous nephropathy is the main type of DM, while mesangial proliferative glomerulonephritis is the most common type in polymyositis. The mechanism underlying the association between DM and glomerulonephritis remains to be elucidated. We herein report a case of DM associated with focal segmental glomerulosclerosis, which has not been reported previously. (Korean J Med 2012;83:828-831)
Vanillic Acid의 MC3T3-E1 조골세포 분화 및 무기질화에 미치는 영향
서현주(Hyun-Ju Seo),손건호(Kun Ho Son),황진현(Jin-hyeon Hwang),김동하(Dong-ha Kim),박유성(Yu Seong Park),권인숙(In-Sook Kwun),조영은(Young-Eun Cho) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.8
마편초과(Verbenaceae)에 속하는 순비기나무(Vitex rotundifolia L.)의 열매를 건조한 만형자(Viticis Fructus)는 오래전부터 감기, 두통, 편두통, 눈의 통증, 근육통 및 염증치료를 위해 사용된 약용식물 자원이다. Vanillic acid(VA; 4-hydroxy-3-methoxybenzoic acid)는 만형자의 생리활성 분획에서 분리된 주요 화합물 중 하나이며, vanillin의 산화형으로 항산화, 항염증 및 항암 활성 등의 약리학적 특성에 대한 연구가 진행되었지만, VA가 골 대사에 미치는 영향에 대한 연구는 거의 없는 실정이다. 본 연구에서는 조골세포 MC3T3-E1 세포의 분화 및 무기질화에 대한 VA의 잠재적인 항골다공증 특성을 조사하였다. MC3T3-E1 세포는 분화배지에 0, 0.1, 1, 10 μg/mL 농도의 VA를 처리하여 3일, 6일 및 9일 동안 배양되었고, ALP 활성도, Von Kossa 및 Alizarin Red 염색법 등에 의해 조골세포의 활성 변화를 분석하였다. 골 관련 단백질 발현량은 western blot에 의해 분석되었다. MC3T3-E1 세포에서 9일 동안 10 μg/mL 농도의 VA를 처리했을 때 ALP 활성이 유의적으로 증가하였다. Von Kossa와 Alizarin Red 염색 결과 VA 처리 후 3일, 6일 및 9일차의 무기질화된 결절이 유의적으로 증가하였다. 또한, VA는 조골세포 성장 및 분화와 관련된 Runx2, ALP, Pro COLI, BMP 2/4 및 p-ERK와 같은 단백질의 발현량을 유의적으로 증가시켰다. 본 연구 결과를 종합해볼 때 VA가 MC3T3-E1 조골세포에서 골 관련 단백질 발현량을 조절할 수 있음을 확인하였으며, 따라서 VA가 조골세포 분화 및 무기질화를 자극하여 항골다공증 효과를 발휘할 수 있을 것으로 사료된다. Vanillic acid (VA), namely 4-hydroxy-3-methoxy benzoic acid, is one of the major compounds isolated from the bioactive fraction of Viticis Fructus. VA is derived from dihydroxybenzoic acid, an oxidized form of vanillin. Although studies on the antioxidant, anti-inflammatory, and anticancer pharmacologic properties of VA have been conducted, there is little research on the effect of VA on bone metabolism. The objective of the present study was to investigate the potential anti-osteoporotic properties of VA on the differentiation and mineralization in osteoblastic MC3T3-E1 cells. These cells were cultured in 0, 0.1, 1, 10 μg/mL VA for 3, 6, and 9 days. The MTT assay results showed that VA had not changed the osteoblastic cell proliferation. Extracellular alkaline phosphatase (ALP) activity increased as VA concentration increased at 9 days. ALP staining was also elevated as VA concentration increased at 6 and 9 days. Markedly, VA significantly increased the mineralized nodules in a dose-dependent manner at 3, 6, and 9 days. In addition, VA significantly increased the expression of the bone differentiation marker ALP at 3 days. The expression of the bone-specific transcription factor Runx2 protein was also elevated in the VA-treated osteoblastic MC3T3-E1 cells at 3 days. The expression of the downstream regulator of bone morphogenetic protein 2 (BMP-2) signaling, phosphorylation of ERK (p-ERK) was slightly elevated in VA-treated osteoblastic MC3T3-E1 cells at 3 days. Our results suggest that VA regulates osteoblast differentiation and mineralization in osteoblastic MC3T3-E1 cells. Taken together, our results clearly demonstrate that VA may be useful in preventing osteoporosis through the stimulation of osteoblastic differentiation and mineralization.