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성하수,김소연,최진일,이준호,김승일,박양찬 한국고분자학회 2023 Macromolecular Research Vol.31 No.2
For an early diagnosis and treatment of infectious diseases, a highly sensitive and reliable detection of a pathogenic microorganism is critical. Conventional immunodiagnostics have a limitation such as a relatively low detection sensitivity to the pathogen. Magnetic particles have been adopted to magnetic antibodies (MAbs) of the pathogen for immunomagnetic diagnostics, in which the MAbs can be detected using a magnetic detector. In this study, carboxymethyl dextran-coated iron oxide nanoparticles (CMD-IONPs) were synthesized using a co-precipitation method through one-pot synthesis. Two types of nanomagnetic antibodies (NMAbs) were prepared via coupling the IONP with the Ab of Enterohemorrhagic Escherichia coli or Salmonela typhimurium. A gel electrophoresis analysis of the NMAbs revealed a successful conjugation of the Abs with the CMD-IONPs. To the IONPs, Ab conjugation efficiencies of EHEC and ST were 99.98% and 92.29%, respectively. The NMAbs based on CMD-IONPs can be a feasible approach to a quantitative and rapid immunomagentic diagnosis of pathogenic microbes.