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- 저자 : 박석돈 ( Dong Lim Kim (검색결과 5 건)
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Vibrio vulnificus cytolysin에 의하여 유발된 전신 Shwartzman 반응에 있어서 cytokines(IL-12, IFN- )의 역할
박석돈(Seok Don Park),김동림(Dong Lim Kim),이상원(Sang Won Lee),전재훈(Jae Hoon Chun),차승훈(Seung Hoon Cha) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.5
N/A Background:Knowledge of the pathogenetic mechanism for the activation of the coagulation system (disseminated intravascular coagulation, DIC) associated with V. vulnificus infection is important for the development of improved modalities for prevention and treatment. The use of experimental model of DIC (generalized Shwartzman reaction, GSR) induced by toxins and cytokines in mice has partly elucidated the pathogenetic pathways that are involved in the development of DIC in septic patients Objective:The purpose of this study was to investigate the role of cytokines (IL-12, IFN-γ) in the pathogenesis of the GSR induced by V. vulnificus cytolysin. Methods:Generally the GSR was elicited by two consecutive injections of V. vulnificus cytolysin. The priming cytolysin intradermal injection was replaced with recombinant murine IL-12 (0.25 or 0.5㎍) and recombinant murine IFN-γ (5 or 10㎍), respectively and was followed by 24 hr later by the cytolysin (1-3 hemolytic units) intravenous challenge injection. The occurrence of GSR was evaluated by mortality rate within 3 days. The death time measured. The gross and histopathological findings of various vital organs were examined shortly after death. Results:When mice were primed with 0.5㎍ IL-12 and challenged 24 hr later with cytolysin, they died completely within 13 hr. This priming effect of IL-12 and provocative effect of cytolysin were dose-dependent. All the mice primed intradermally with IFN-γ(10㎍) died within 9 hr. The priming effect of IFN-γ was dose-dependent. In the gross and histopathologic examinations of various organs in dead mice, pathologic changes were observed mainly in the lungs.Conclusion:These results suggest that the pathomechanisms of V. vulnificus cytolysin-induced lethal GSR in mice is dependent upon IFN-γ synthesis triggered by cytolysin-induced IL-12 production. (Korean J Dermatol 2000;38(5):622~628)
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정상 섬유아세포와 말초 혈액 단핵 세포가 편평상피 세포암 세포 ( SCL - 1 ) 에 미치는 영향
이창화(Chang Hwa Lee),김동림(Dong Lim Kim),박석돈(Seok Don Park) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.3
Many carcinomas have an active mononuclear cell infiltrates surrounding tumor. Various in vitro assays have shown that cellular constituents of peripheral blood mononuclear cells(PBMC) can alter growth of carcinoma cell line. Author compared the effects of normal fibroblasts on squamous cell carcinoma cell line(SCL-1) along with those of sctivated and/or nonactivated PBMC on SCI 1 using a skin equivalent system. This system prevents direct cellular contact by growing SCL-1 on an overlying Millicell-HA membrane and normal fibroblast or supernatants of PBMC in a lower chamber. Normal fibroblasts enhanced the outgrowth of SCL-1 and induced a more organized phenotype of SCL-1. Supernatants from nonstimulated PBMC suppressed outgrowth of SCL 1, and concanavalin A stimulated PBMC supernatants alterd rnorphology of cultured SCL-1 from a disorganized phenotype to a more organized phenotype. It is concluded that fibroblasts and PBMC may affect the growth and differentiation of SCL-1 via their mediators(cytokines)
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옻닭에 의한 전신성 접촉 피부염 147예의 임상적 고찰
원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ),김동림 ( Dong Lim Kim ),박재훈 ( Jae Hun Park ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.6
Background: Systemic contact dermatitis (SCD) due to the ingestion of Japanese lacquer tree (Rhus verniciflua) is pretty common in Korea, and it is on a trend of increment. It is thought that the increase in ingestion of chickens boiled with the lacquer tree has been caused by the regard of the lacquer tree as a health food or herbal medicine for gastrointestinal disease. Objective: To review the clinical findings and laboratory findings, and to make people aware of the harmful effects of the lacquer tree. Methods: We retrospectively reviewed the medical records of 147 patients who had SCD due to chicken boiled with lacquer tree, 98 patients in Wonkwang University Hospital over the last 20 years (1998∼2007) and 49 patients in Areumdaun Dermatology Clinic over the past 5 months (August∼December, 2007). Results: The sex ratio of patients (male to female) was 1.3:1 and the average age was 44.0 years old (range: 11∼76). They ate chicken boiled with lacquer tree as a health food (42.9%) and for the treatment of gastrointestinal disease (22.4%). The mean incubation period was 47.7 hours (range: 30 min∼16 days). The first symptoms they had were erythematous maculopapules (42.9%), itching without rash (33.7%), and edematous change (16.3%). The skin lesions developed as maculopapules (50.6%), erythroderma (40.9%), and erythema multiforme-like lesion (8.4%), vesicles, wheals, purpura, and pustules. On laboratory findings, some people had leukocytosis (61.2%), increment of Ig E (26.4%), abnormalities of liver function test (ALT:16.3%, AST:4.1%). Sixty percent of patients had a history of contact dermititous contracted via chicken boiled with rhus lacquer ingestion (36.7%) or contact with the lacquer tree. Clinical symptoms were developed by 29.5% who ate chicken boiled with lacquer. Mainly they had been treated with corticosteroids, antihistamines. The mean period needed for treatment was 8±2.4 days. Conclusion: Systemic contact dermatitis due to ingestion of the lacquer tree was developed in either sensitized or non-sensitized persons. It is suggested that SCD is caused by the highly allergic and toxic effects of lacquer. Physicians need to make people aware of the harmful effects of the lacquer tree and educate people not to ingest it. (Korean J Dermatol 2008;46(6):761∼768)
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