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백굴채약침액(白屈菜藥針液)이 LPS로 유도(誘導)된 RAW 264.7 대식세포(大食細胞)에서의 항염증효과(抗炎症效果)
박동천 ( Dong Cheon Park ),박지현 ( Ji Hyeon Park ),이우경 ( U Kyung Lee ),이진규 ( Jin Kyu Leek ),서일복 ( Il Bok Seo ),김호현 ( Ho Hyun Kim ),김정선 ( Jeong Seon Kim ),김이화 ( Ee Hwa Kim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.2
Objectives: Recently, Herbal-acupuncture therapeutics has been used for the treatment of inflammatory diseases such as rheumatoid arthritis. Especially, we have been interested in chemical mediators concerned with inflammation such as prostaglandin, cytokine, nitrous oxide. The purpose of this study is investigated that the effect of Chelidonii Herbal-acupuncture solution in lipopolysaccharide-stimulated RAW 264.7 macrophages, performed several expeimental items: those are prostaglandin E2, nitric oxide and cyclooxygenase-2. Methods: The cytotoxicity of Chelidonii Herbal-acupuncture solution in RAW 264.7 macrophages were measured by MTT-based cytotoxicity assay. In order to observe cyclooxygenase-2 mRNA expression in lipopolysaccharide-stimulated RAW 264.7 macrophages, RT-PCR was used. Prostaglandin E2 formation and nitric oxide production was measured by competitive enzyme immunoassay and Griess assay. Results: 1. The MTT assay demonstrated that cytotoxic effect of Chelidonii Herbal-acupuncture solution in RAW 264.7 macrophages were not appeared before concentration of 1㎎/㎖. 2. Chelidonii Herbal-acupuncture solution inhibited cyclooxygenase-2 mRNA expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. 3. Chelidonii Herbal-acupuncture solution inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. 4. Chelidonii Herbal-acupuncture solution inhibited prostaglandin E2 formation in lipopolysaccharide-stimulated RAW 264.7 macrophages. Conclusions: On the basis of these results, It was shown that Chelidonii Herbal-acupuncture solution is significantly able to inhibit the production of PGE2 and NO, as well as COX-2 mRNA expression. Our results may provide new mechanism by which Chelidonii Herbal-acupuncture solution accounts for its beneficial effect on accelerating wound healing and anti-inflammation.
박동천(Park Dong-Cheon),송훈(Song Hun),김정진(Kim Jeong-Jin) 대한건축학회 2007 大韓建築學會論文集 : 構造系 Vol.23 No.10
This study is about thermal conductivity of polymer modified cement mortars (PCM) used as the patch repair method materials. The thermal conductivity is one of major input data in the analytic study such as FEM. The quick thermal conductivity meter based on the unsteady hot wire method was used. To consider the interacted factors influencing thermal conductivity of PCM, five testing variables such as age, types of polymers, polymer fraction, fine aggregate fraction, and moisture content condition of specimen were adopted in this test. Multiple regression equation was estimated from the test results.
박동천 ( Park Dong-cheon ),이준해 ( Lee Jun-hae ),김용로 ( Kim Yong-ro ),송영찬 ( Song Yong-chan ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.2
Lack of fine aggregate is adversely affecting the quality of concrete. Due to lack of land sand, EZZ sea sand has been used. However, the use of sea sand is also difficult because of the opposition of fishermen. The purpose of this study was to analysis the effect of slag fine aggregate to durability and compressive strength of concrete. The concrete compressive strength and durability were assessed to derive a proper mix ratio of fine aggregate.
이산화탄소 증가의 환경영향을 고려한 콘크리트 중성화에 관한 연구
박동천(Park Dong-Cheon),송화철(Song Hwa-Cheol) 대한건축학회 2009 大韓建築學會論文集 : 構造系 Vol.25 No.9
To estimate the compatibility of concrete cover criterion, the change of carbonation depth was calculated by FEM model considering the effect of carbon dioxide increase of the earth which is from SRES(Special Report on Emission Scenario) published by ICCP. The period of carbonation calculation is from 2000 to 2100. The difference of carbonation depth between A1F1 scenario which is the severest among the SRES scenario and constant carbon dioxide concentration(369ppm) for 100 years is 0.0042m. The smaller difference than the result we expected is attributed to concrete pore decrement and the diffusion of calcium hydrate which is cement hydration product. The difference by water cement ratio is also small because of the increment of calcium hydrate according to the change of the amount of unit cement.
실내 이산화탄소 농도 측정 및 편차에 따른 콘크리트 탄산화 깊이 예측에 관한 해석적 연구
박동천(Park Dong-Cheon),송훈(Song Hun),이동운(Lee Dong-Un) 대한건축학회 2012 大韓建築學會論文集 : 構造系 Vol.28 No.4
Carbon dioxide in atmosphere causes concrete carbonation which is the phenomenon, that is, the pH of concrete goes down from 12-13 to 8.85-10. Even though the carbon dioxide concentration of indoor is higher than that of outdoor, the micro measurement has not carried out. The concentration test was conducted three times in two rooms in a residential area, reading room in library, and lecture room. With all the deviation for each unit, the measured average value was 463.1~1425.3(ppm) which is more than three times than that of outdoor at the most. Without surface finishings in FEM calculation, the depth of carbonation is up to 4(㎝). At the same time, the FEM calculation considering surface finishings. Any carbonation did not appeared because of the assumption, that is, surface finishings did not deteriorate.
온도와 습도의 변화에 따른 콘크리트 내부의 열, 수분 분포 예측
박동천 ( Park Dong-cheon ),이준해 ( Lee Jun-hae ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.1
Concrete changes its internal moisture distribution depending on the external environment, and changes in the condition of the material's interior over time affect the performance of the concrete. These effects are closely related to the long-term behavior and durability of concrete, and the degree of deterioration varies from climate to climate in each region. In this study, we use actual climate data from each region with distinct climates. A multi-physical analysis based on the method was conducted to predict the difference and degree of deterioration rate by climate.
환경변화에 따른 콘크리트 내부의 열ㆍ수분 경년변화 예측에 관한 해석적 연구
박동천(Park Dong-Cheon),김정진(Kim Jeong-Jin),오상균(Oh Sang-Gyun),김효열(Kim Hyo-Youl),강병희(Kang Byeung-Hee) 대한건축학회 2007 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.27 No.1
The deteriorations of concrete structures such as carbonation, chloride attack, alkali-aggregate reaction, freezing damage usually depend on the moisture state in concrete. The diffusion coefficient and reaction rate of the deteriorative factors are changed by the moisture content and temperature. To evaluate the temperature and moisture content which are essential to expect the concrete deterioration qualitatively, heat-moisture coupled model was constructed by FEM. The model was verified by the existing experimental results.
일제시대 건설된 해양 콘크리트구조물의 물성 평가(영도대교)
박동천(Dong-Cheon. Park),안재철(Jae-Cheol Ahn) 한국항해항만학회 2013 한국항해항만학회지 Vol.37 No.2
YoungDo bridge is the first suspension bridge in Busan which experienced several times repair and reinforcement after completion in 1934. The bridge is under demolition for extension and restoration work since 2011. The purpose of this research is to establish data base about modern concrete. The mix design of the concrete is like that cement : fine aggregate : coarse aggregate = 1 : 2 : 4 or 1 : 3 : 6 by the parts. The compressive strength is in the ranges from 50 to 55 MPa and the elastic modulus is in the ranges from 25 to 35 GPa. From the fact that the deviation is less than 10 %, considerably high quality control was conducted in those days. The carbonation depth is 5.92 cm at the bridge post and 14.3 cm at the machine room. That is why ocean environment keeps the high humidity. The diffusion coefficient of chloride ion through the pores in concrete is 1.052e-12 m2/s from the regression analysis using the experiment data. The water cement ration is estimated at approximately 35 % in case if the concrete using ordinary Portland cement. 영도대교는 부산 최초의 연륙교로서 1934년 준공된 이후, 수차례의 보수보강 공사를 거쳤으며 2011년 이후 현재까지 확장 복원을 위하여 철거공사를 실시하고 있다. 본 조사연구의 목적은 영도대교 건설 당시의 교량 기술 및 재료적 특성 분석 함으로써 근대 구조에 사용된 콘크리트의 당시 재료적 특성을 파악하고 근대 교량문화유산의 보존 및 활용을 위한 기초적 자료를 구축하는 데 있다. 일련의 실험을 통하여 콘크리트 구성재료는 시멘트 : 세골재 : 굵은골재 비율이 부위에 따라 1 : 2 : 4 또는 1 : 3 : 6 인 것으로 밝혀졌고, 압축강도는 50∼55MPa, 탄성계수는 25∼35GPa의 범위로 나타났다. 역학적 물성의 편차가 10%이하인 점을 미뤄봐서 당시의 품질관리가 비교적 우수했던 것을 알 수 있었다. 중성화 깊이는 높은 상대습도로 상당히 낮은 값을 나타내었고, 염소이온 확산계수는 1.052e-12(m2/s)로서 현대 콘크리트와 비교하면 물시멘트비 35%에 상응하는 것으로 밝혀졌다.
콘크리트 강도차에 따른 함수율 분포의 변동에 관한 실험적 연구
박동천 ( Park Dong-cheon ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.1
The temperature and relative humidity in concrete change with the passage of time depending on factors such as compressive strength. They are also different depending upon internal depth of concrete. In this study, we have measured the change of the temperature and relative humidity in the concrete for two years to act as the parameters to evaluate the concrete durability and effective maintenance.