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흰쥐 비점막에서 Capsaicin 재노출에 의한 신경성 염증반응의 증가기전에서 산화질소의 역할
마용운,전시영,김진평,안성기 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.2
Background and Objectives:The role of neurogenic inflammation in the airways appears to protect the airways from various irritants in the inspired air. Enhanced NO production by inducible NO synthase (iNOS)inflamation, has been implicated in the pathogenesis of inflamation. We studied to elucidate the role of NO in the pathogenesis of neurogenic inflammation in the nasal mucosa. Material and Method:This study investigated the changes of microvascular leakage in the rat model of challenge/rechallenge with capsaicin, following the efects of a NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) and a substrate, L-arginine. And for more evident profs, this study investigated the immunohisto-chemical localization of the expressed iNOS after capsaicin-challenge in the rat nasal mucosa. Results:Capsaicin-rechallenge enhanced microvascular leakage in the nasal mucosa. Pretreatment with L-NAME inhibited the enhancement of neurogenic inflamation with capsaicin-rechallenge, and L-arginine reversed the inhibition of L-NAME. Strong imunohistochemical staining for iNOS was localized to inflamatory cells in the epithelial layer. Conclusion:Capsaicin or sensory neuropeptides may mediate the enhancement of neurogenic inflammation with capsaicin-rechallenge. (Korean J Otolaryngol 2003 ;46 :115-9)