http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
소세포폐암에서 Cisplatin 과 Etoposide 복합 화학요법 및 방사선 병합치료의 장기간 관찰결과 ( 최종보고 )
류혜영(Hyae Young Lew),최환석(Hwan Seok Choi),박지훈(Ji Hoon Park),김정희(Jeong Hee Kim),김시영(Si Young Kim),윤휘중(Hwi Joong Yoon),홍성언(Sung Eun Hong),조경삼(Kyung Sam Cho) 대한내과학회 1996 대한내과학회지 Vol.50 No.6
Objectives: Small cell lung cancer is the one of solid tumors most responsive to chemotherapy and radiation therapy. Most commonly used combined therapeutic regimen was CAV(cyclophosphamide, adriamycin, vincristine), Reports of the cisplatin plus VP-16(VPP) combination as second line therapy following CAV suggested that VPP might be non- cross resistant with the CAV regimen. We evaluated the efficacy and toxicity of VPP combination therapy as a first line therapy for small cell lung cancer (SCLC) Methods: Forty-four patients with SCLC were treated with cisplatin (20mg/m2 i,v., X days) and etoposide (100mg/m2 i.v., X 3 days) every three weeks. In patients with limited disease, radiation to primary site was performed at 3rd or 4th cycle of VPP. Results: 1) Forty two patients were evaluated for response to VPP chemotherapy. The two patients were excluded because they died before evaluating response to chemotherapy. The overall response rate was 72%(CR 24%, PR 48%). The response rate of limited disease and extensive disease was 77% and 63% respectively. 2) The median overall survival time was 52 weeks. Survival rates of 1year, 3years, and 5years were 50%, 12%, and 9% respectively. The median survival time was 59weeks in limited disease and 44 weeks in extensive disease. 3) The median time to progression was 49weeks in responders. 4) Leukopenia(grade III, IV) was 7.8% and thrombocytopenia(grade III, 1V) was 2.0%. Anorexia, nausea, and alopecia was observed in most cases, but the degree was mild to moderate. 5) Toxicities to radiation therapy were radiation pneumonities in 50%, radiation esophagities in 28%. The delay of chemotherapy due to radiation toxicity occured in 72%, In the patients with limited disease receiving thoracic radiation therapy, relapse rates were 88.9%. The intrathoracic relapse occured in 35% and extrathoracic relapse occured in 65%. Conclusion - VPP regimens in small cell lung cancer were less toxic than other regimens, but it's efficacy was equiva1ent. Thereafter futher investigations are required for new chemotherapeutic agents, higher dose chmotherapy and autologous bone marrow transplantation and modifying drug to resistance to chemotherapy, Also, the investigations for methods which can increasing efficacy and decreasing toxicity of radiation therapy for limited disease are required.
류혜영(Hyae Young Lew),손경환(Kyung Hwan Son),이무열(Moo Yel Lee),강흥선(Heung Sun Kang),임천규(Chun Gyoo Ihm),김권삼(Kwon Sam Kim),정경천(Kyung Cheon Chung),성동욱(Dong Wook Sung),김명식(Myung Shick Kim),구혜수(Hae Soo Ku) 대한내과학회 1996 대한내과학회지 Vol.51 No.5
Mononeuritis multiplex is known to occur in many illness including certain types of systemic vasculitis, ANCA has been described in association with Wegener`s granulomatosis, polyarteritis nodosa, and pauci-immune necrotizing crescentic glomerulonephritis, since it was first reported in 1982 by Davis et al in patients who had necrotizing glomerulonephritis with no immune deposits. ANCA may well be useful in distinguishing cases mediated by vasculitis from those produced by other processes, especially early in the course of a disease. We report a case of mononeuritis multiplex due to ANCA associated vasculitis. We diagnosed vasculitis neuropathy by sural nerve biopsy and angiography. The patient was treated with prednisolone and oral cyclophosphamide. Her subjective symptoms and objective signs were improved. Subsequent examination of ANCA was negative.
급성 하벽심근경색증에 동반된 ST 절의 상호 하강 ( V₁ - V₃ ) 에 대한 연구
류혜영(Hyae Young Lew),윤용선(Yong Sun Yun),강흥선(Heung Sun Kang),조정휘(Chung Whee Choue),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),송정상(Jung Sang Song),배종화(Jong Wha Bae) 대한내과학회 1997 대한내과학회지 Vol.53 No.3
Background: Reciprocal ST-segment depression in precordial leads is a common finding in acute inferior myocardial infarction. The responsible mechanism and the significance of this finding, however, are still controversial. Methods: From January 1991 to December 1994, 38 patients with acute inferior myocardial infarction were treated at the Department of Internal Medicine in Kyung Hee University Hospital. Clinical characteristics, serial electrocardiograms, and angiographic findings of coronary artery and left ventriculography, echocardiography were reviewed. Reciprocal ST-segment depression was defined as ST-segment depression≥1.0mm in two or more adjacent precordial leads(V₁-V₃) in patients with acute inferior myocardial infarction showing ST-segment elevation in II, III, aVF. Coronary angiography and echocardiography were performed within 24 hours from admission. In this study, angiographic distribution score was used to define the perfusion territory causing inferior ischemia. Results : 1) The summation of ST-segment elevation in II, III, aVF leads was significantly more higher in group H than group A (P<0.05). 2) However, the angiographic distribution score, peak CK levels, in-hospital complications and ejection fraction showed no difference between two groups (P>0.05). 3) There were no evidence of anterior wall motion abnormality in two groups. Conclusions: Our results suggest that the S'I'- segment depression on the precordial leads in acute myocardial infarction can be explained mainly by benign reciprocal electrical change.