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양성, 전암성, 암성 표피종양에서의 p21, p27 and β-catenin 발현에 대한 분석
류려선,최종환,서재홍 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Analysis of p21, p27 and β-catenin protein expression in the non cancerous, precancerous and cancerous epidermal skin tumors. Background: The epidermal skin tumors encompass a wide range of non cancerous, precancerous and cancerous conditions. The pathogenesis of seborrheic keratosis, keratoacanthoma, actinic keratosis, Bowen's disease and squamous cell carcinoma is not well understood. Objectives: The purpose of this study was to investigate the expression of p21, p27 and β-catenin in this lesions. Methods: Immunoperoxidase staining methods were applied to analyze p21, p27 and β-catenin expression in a total of 61 cases, including 21 seborrheic keratosis, 9 keratoacanthoma, 8 actinic keratoses, 6 Bowen's diseases and 17 squamous cell carcinoma. p21 is thought to mediate p53 signaling, induced by a DNA-damaged status, to arrest the cell cycle, the mechanism that controls p21 expression has not been clearly elucidated yet. p27 is a member of cip/kip family of cydin-dependent kinase inhibitors, which include the p21, p27, and p57 protein, the p27 protein is present in quiescent cells are stimulated by growth factors, a decrease or an absence of p27 protein expression has been suggested to be a powerful negative prognostic marker in patients with various malignancies, including breast, colon, and esophageal cancers. Results: p21 was expressed in 85.7% (18/21) of seborrheic keratsis, 33.3% (3/9) of keratoacanthoma, 75% (6/8) of actinic keratosis, 33.3% (2/6) of Bowen's Disease and 76.5% (13/17) of squamous cell carcinoma An increased expression of p21 was found 85.7% (18/21) of seborrheic keratosis. p27 was expressed in 100% (21/21) of seborrheic keratosis, 11.1% (1/9)of keratoacanthoma, 25% (2/8) of actinic keratosis, 83.3% (5/6) of Bowen's disease and 82.4% (14/17) of squamous cell carcinoma An increased expression of p27 was found 100% (21/21) of seborrheic keratosis. β-catenin expressed in 100% (21/21) of seborrheic keratosis 100% (8/8) of actinin keratosis, 100% (9/9) of actinic keratosis, 83.3% (5/6) of Bowen's disease and 88.2% (15/17) of squamous cell carcinoma in conclusion. Expression for p21 are low in seborrheic keratosis, keratoacanthoma, actinic keratosis, Bowen's disease and squamous cell carcinoma. In the seborrheic keratosis, strong expression of the cyclin-dependent kinase inhibitor. Our results support that p21, p27 protein and β -catenin play a role in keratinocyte differentiation and tumorigenesis of skin lesion.
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방광의 요로상피암종에서 p27, p53, p73 단백 발현에 대한 연구
이상호,류려선,서재홍 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1
The Aim of this study was to investigate the expression of p27, p53 and p73 proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between pathologic parameters and each protein expression level. The expression of p27, p53 and p73 proteins were studied in 21 urothelial carcinoma, high glade, 12 urothelial carcinoma, low glade, 7 urothelial carcinoma in situ, 9 cystitis cystica and 9 chronic cystitis by immunohistochemistry, The positive expression of the p27, p53 and p73 protein was significantly associated with high grade and stromal invasion. Our data suggest that p27, p53 and p73 protein may be involved in the development and progression of urothelial carcinoma. In addition, p53 may be a useful prognostic marker for individual urothelial carcinoma patients.
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자궁내막증 판별에 대한 표지자로 β-catenin에 대한 연구
최종환,류려선,서재홍 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Backgrounds: β-catenin, a member of the catenin family, is an adhesion molecule normally present in the sub-plasmalemmal cell membrane. It is abnormally transferred to the nuclei when the adenomatous polyposis coli pathway, on which it depends, is altered. Abnormal β-catenin expression is documented in fibromatosis, intestinal polyps and endometrial carcinoma. The diagnosis of endometriosis is usually straightforward. However, it may be difficult to distinguish between endometriosis and other entities when the epithelial component is scare. There is currently no other marker that helps support the diagnosis of endometriosis. Design: This study aimed at: (a) determining whether β-catenin can identify normal endometrial tissue (proliferative phases and secretory phases), and (b) Validating the potential utility of β-catenin in identifying the stroma and glands in endometriosis. In addition to 22 cases of normal endometrial tissue. We tested 46 cases of endometriosis using β-catenin antibody (clone 14, transduction Labs) via immunohistochemistry. Results: 43 out of 46 cases of endometriosis showed Co-expression of β-catenin on both the gland and storma (either nuclear or membranous pattern). In the remaining 3 cases, β-catenin's expression was only focal. The stroma in 21 out of 22 cases of normal endometrium was detected by β-catenin, showing either a membranous or nuclear signal. In only 1 case, the signal distribution was very focal. No of the internal negative control tissues (ovarian stroma, myometrium) showed any significant levels of β-catenin expression. Conclusion: This study shows that β-catenin can successfully detect the glandular and stromal components of endometriosis, with a striking contrast to surrounding tissue, resulting in a very 'clean' background. β-catenin, thus, has the potential of identifying these lesions in morphologically equivocal situations. The mechanisms of abnormal expression of β-catenin on the stroma of endometriosis is unclear, and warrants further investigations.
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이상호,류려선,서재홍 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1
Papillary carcinoma of the thyroid (PTC) is the commonest thyroid cancer. Diagnosis of papillary thyroid carcinoma, in many but not all cases, is an easily achievable diagnosis with almost minimal interobservable variability between pathologists. However since the introduction of follicular variant of PTC and the wide threshold range in interpretation of the clearly set pathological criteria for diagnosis of PTC, between pathologists including experts, the diagnosis in some cases became quite difficult. Unfortunately some cases are unjustifiably over-called as follicular variant of PTC as result of the wide inter observable variability between pathologists. CD56 is a neural cell adhesion molecule, hence its expression may affect the migratory capacity of tumor cells. The tumor suppressor protein p53 has recently been shown to belong to a family that includes two structurally related proteins, p63 and p73. Expression of p63, a transcription factor that is transcribed into six isoforms, is important for the regulation of normal development. In this study, we assessed the protein expression and loss using antibodies against CD56 and p63 in normal follicular thyroid neoplasms in an attempt to evaluate its diagnostic value. A total 109 cases were studied with tissues from 49 carcinoma (33 classic papillary carcinoma, 16 follicular variants of papillary carcinoma), 15 follicular adenoma, 17 nodular hyperplasia, 17 lymphocytic thyroiditis and 11 normal thyroid evaluated by immunohistochemistry for the expression of this marker. Our results showed CD56 positive in all the lesions and adenomas except for PTC. CD56 was negative in all PTC cases. p63 showed selective focal positivity in PTC cases, in contrast to other non PTC lesions/tumors. p63 expression was in 25 out of 33 cases of PTC and was consistently absent in all the non PTC cases. Our aim was to study the applicability of difference in CD56, p63 expression as a marker that distin-guishes PTC, including the follicular variant from other We concluded that a panel consisted of CD56 and p63 is of value in distinction of PTC from other thyroid follicular lesion. p63 is a specific but less sensitive marker for PTC than CD56. CD56 is more specific and sensitive marker than p63, however it is a negative rather then a positive marker for PTC.
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