http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
상피성 난소암과 그의 전구 병변으로서 양성 및 경계성 난소종양의 관계에 관한 분자 유전학적 연구
남주현(Joo Hyun Nam),김종혁(Jong Hyuk Kim),허주령(Joo Ryung Hur),박건구(Gun Goo Park),김용만(Yong Man Kim),김영탁(Young Tak Kim),목정은(Jung Eun Mok),강순범(Soon Bum Kang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.12
Objective : To investigate the potential role of benign and borderline ovarian tumor as precursor of malignant tumor by the evaluation of p53 tumor suppressor gene mutation analyses and clonality assay using microdissection technique. Materials & methods : Archival tissue samples from 15 patients with primary epithelial ovarian cancer were evaluated. Using a precise microdissection technique under light microscope (X 100 magnitude), cells from benign, borderline and malignant lesions were isolated and genomic DNA from each sample was extracted by xylene-proteinase K method. Each sample was analysed by direct sequencing of exon 5-8 of p53 tumor suppressor gene and clonality assay. Clonality analyses were performed using a polymerase chain reaction (PCR)-based assay for X chromosome inactivation. Results : Microdissection was successfully performed in all 15 cases. There was no p53 gene mutation in benign and borderline lesion and 6 cases of malignant lesion showed base substitution or insertional mutations. All the benign cases except one and all the borderline lesions showed polyclonality, but 5 cases of the malignant lesion were monoclonal. Although one benign lesion tested were monoclonal, corresponding borderline and malignant lesions were polyclonal. Conclusion : Benign or borderline ovarian tumors are distinguishable from malignant tumors molecular biologically, even when this benign or borderline lesion is adjacent to malignant one. This result suggests that the benign and borderline ovarian tumors have no potential role as precursors of malignant ovarian tumor.
남주현 ( Joo Hyun Nam ),안정좌 ( Joung Jwa Ahn ),서전규 ( Jun Kyu Suh ),김도완 ( Do Wan Kim ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.4
본 연구는 참외 껍질의 첨가가 배추 김치의 맛과 발효 숙성에 미치는 영향을 알아보기 위해 기치 제조에 절임배추 무게를 기준으로 참외 껍질 첨가량을 0. 10. 20. 30%(W/W)로 첨가량을 달리하여 김치를 제조한 후 15℃에서 28일간 발효시키면서 pH, 산도, 총균수, 젖산균수 등의 이화학 및 미생물학적 특성을 조사하고, 관능적 특성인 맛과 색도, 씸힘성, 전체적인 기호도 등을 평가하였다. 참외 김치의 pH 변화는 발효 초기 모든 실험구에서 pH 4.76~4.87로 비슷하였으나, 대조구에서는 7~21일사이에 급격히 pH가 떨어져 과숙 현상을 보였으나, 참외 껍질 첨가구에서는 14일까지 유지하다가 14~21일 사이에 pH 4.13~4.41에 도달하여 28일가지 유지되었다. 참외 김치의 산도 변화는 최기에는 참외 껍질첨가구에서 다소 높았으나, 발효가 진행되면서 오히려 대조구에 비해 낮은 산도 값이 나타났다. 참외 김치의 총균수를 측정한 결과, 발효 7일부터 참외 껍질 첨가구의 총균수가 대조구에 비해 낮게 관찰되면서 발효 마지막까지 유지되었다.참외 김치의 젖산균 수를 관찰한 결과도 총균수와 비슷한 양상을 보였는데, 이것은 참외 겁질의 항균 작용에 의해 김치의 발효 및 숙성이 지연되는 것으로 생각된다. 참외 김치의 관능검사 결과, 맛은 20% 참외 껍질 첨가구에서 대조구에 비해 유의적으로 높게 나타났으며, 전체적인 기호도에서는 참외껍질 20% 첨가구이 가장 높은 선호를 나타내었다. 이상의 결과에서 배추 김치에 참외 껍질을 20% 첨가한 처리구가 이화학 및 미생물학적인 실험 결과에서 발효를 지연시키고 적숙기를 연장시켜 주었으며, 관능 검사 결과의 전반적인 기호도에서도 높은 점수를 나타내었다. 다라서 배추 김치를 담글 때 참외 껍질을 첨가하는 것이 발효를 지연시켜 맛과 저장성을 향상시켜 줄 것으로 기대된다. This study was performed in Older to evaluate the quality properties of Kinmchi containing 0%, 10% 20%, and 30% of oriental melon peel parts. The Kimchi was fermented for 28 days at a temperature of 15 ℃ The pH, titratable acidity, total microbial counts, and lactic acid counts were measured, and the sensory characteristics including taste, color, chewiness, and overall accepl3bilily were evaluated During the 28 days of fementation, the pH dramatically decreased between the 7th and 21 st day of the fermentation period, and maintained thereafter in control (0%). However, the pH in peel-added groups slightly increased up to the 14th day find decreased up to the 21st day with 4.13 -4.41. The total microbial counts in control were significantly higher than those in the peel-added groups. This trend was maintained throughout the fermentation period. A similar trend was found in the lactic acid microbial counts throughout tile fermentation period During Ole sensory analysis, the values of taste were significantly higher in the 20% and 30% peel-added Kimchi. while the chewiness and overall acceptability were significantly higher in the 20% peel-added Kimchi than those in control. This study showed an improvement in the storage period of Kimchi products with 20% of oriental melon peel, as well as thc possibility of a commercial Kimchi manufacture.
자궁경부암 환자에서 복강경하 근치 자궁적출술과 복식 근치 자궁적출술의 비교 연구
남주현 ( Joo Hyun Nam ),김종혁 ( Jong Hyeok Kim ),김대연 ( Dae Yeon Kim ),김미경 ( Mi Kyung Kim ),유항조 ( Hang Jo Yoo ),김용만 ( Yong Man Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1
Objective : To evaluate the outcomes of laparoscopico-vaginal (modified) radical hysterectomy and to compare surgical parameters and recurrence rate of these with those of conventional abdominal radical hysterectomy. Methods : From October 1997 to March 2
남주현 ( Joo Hyun Nam ),( Woo Kyung Kim ) 한국피부장벽학회 2015 한국피부장벽학회지 Vol.17 No.2
Intracellular Ca(2+) signaling via various calcium channels, such as Orai1, Transient receptor potential (TRP)A1 and TRPV3, has been shown to directly modulate epidermal proliferation, differentiation, barrier homeostasis, and inflammation. Ca(2+) influx through these channels eventually generates intracellular Ca(2+) signaling that results in different outcomes dependent on the individual Ca(2+) channel type, for example, keratinocyte proliferation and migration through Orai1, epidermal barrier formation and keratinocyte differentiation through TRPA1, and keratinocyte cornification through TRPV3. Therefore, a specific agonist/antagonist for each calcium channel is required for maintaining skin barrier homeostasis and for the treatment of dermatological diseases. To identify applicable topical botanically derived chemicals for use in functional cosmetics or agents for dermatological diseases. Novel modulators of Orai1, TRPA1 and TRPV3 were identified were identified by screening the extracts (plus their fractions) of 30 medicinal herbs and their constituents. The potencies of the activating and inhibitory compounds of each channel were determined by an automated patch clamp system. The biophysical properties of channel modulation by hit products were re-analyzed using conventional whole-cell patch clamp and fluorometric calcium imaging. We prepared the extracts of 30 medicinal herbs, performed bioassay-guided fractionation of the active extracts, and then isolated and identified the bioactive constituents. By performing the combination of automated and conventional whole-cell patch clamp studies, we found eight medicinal herb fractions for Orai1, two for TRPA1, and three for TRPV3 that showed >50% inhibition rates at 30 μg/mL. We also found three fractions with TRPA1 agonist activity. Chemical constituents that showed agonist/antagonistic effects also will be discussed. Considering that most regional plants have not been investigated chemically or pharmaceutically, they remain as untapped potential sources of topical agents for cosmetics and drugs. We found major active components and chemical constituents of plant extracts for the modulation of various calcium ion channels, which may have potential clinical applications for abnormal skin barrier functions such as atopic dermatitis, elastosis, and contact dermatitis and so on. Extensive clinical studies of the lead compounds are needed to develop topical agents for dermatological diseases that relate to skin barrier functions.
남주현(Joo Hyun Nam),김성훈(Sung Hoon Kim),김종혁(Jong Hyeok Kim),김용만(Yong Man Kim),김영탁(Young Tak Kim),목정은(Jung Eun Mok) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
Objective : To review and evaluate a series of patients who underwent surgical management due to microinvasive cervical cancer Materials and Methods : Records of 221 patients with microinvasive cervical cancer treated in Asan Medical Center (AMC) from June 1989 to December 2000 were reviewed. Demographic profile, findings in preoperative work-up, treatment modality, histologic findings and post-treatment clinical course were evaluated. Results : The age range at initial operation was 27 to 79 and the mean age was 44.5±11.4 (mean±SD) years. Patients were followed from 3 months to 11.7 years with median follow-up interval of 4.5 years. According to the pathologic report, 212 cases (95.9%) were diagnosed as squamous cell carcinoma and 9 cases (4.1%) as adenocarcinoma. The number of patients with FIGO stage Ia1 and Ia2 disease was 202 (91.4%) and 19 (8.6%), respectively. The cases with invasion of ≤ 1 mm, > 1 mm but ≤ 3 mm, and > 3 mm but ≤ 5 mm were noted in 120 (54.3%), 82 (37.1%), and 19 (8.6%) patients, respectively. Pelvic lymph node dissection (PLND) was performed in 140 patients and the average number of lymph nodes examined per case was 21±7. None of the 140 patients had metastasis to pelvic lymph node. Lymphovascular space invasion was identified in 7 patients. Pelvic recurrence was developed in only one patient and none of the 221 patients has died from recurrent disease. Conclusion : This study shows that patients with microinvasive cervical cancer have no pelvic lymph node metastasis, rare recurrence, and very excellent prognosis, so, if indicated, conservative management or non-radical surgery excluding pelvic lymph node dissection could be tried.