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진동에 의한 혈관 내 폐 보조장치에서의 기체전달의 향상
나도춘,김기범,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-
When the Microporous hollow fiber membrane(MHFM) was contacted with whole blood, the serum leakage(membrane fouling) was occurred in the MFHM. In general, the MHFM was in use at most intravascular lung assist device(IVALAD) which was often occurred the serum leakage, and these serum leakage were reduced the gas exchange. In this work, we tried to improve gas exchange on the IVALAD by using vibration technique. As a result, it was showed that the vibrating method of this module was very effective due to the reduction of serum leakage on MFHM. Therefore, this method was increased gas exchange, respectively.
헤모글로빈의 Microencapsulation에 의한 인공적혈구의 산소전달과 용혈도에 관한 연구
나도춘,김기범,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-
In this study, we tried to improve oxygen transfer rate and reduce pressure drop on intravascular lung assist device with microencapsulation of red blood cells, because microcapsulation of red cells reduce blood hemolysis. Hemoglobin was purified from outdated human red blood cells used. Phospholipid was purified from egg yolk. The hemosome was prepared by encapsulation of hemoglobin with phospholipid multilayer, using rotary vacuum evaporator. The function of hemosome and hemosome/blood mixed solution was tested by measuring oxygen dissociation curve using blood gas analyzer. Also we were measured about hemolysis of hemosome, hemosome/blood mixed solution and blood by absorptivity method. As a results, the oxygen dissociation curve of hemosome and hemosome/blood mixed solution showed the same figure as the curve of normal red blood cells. Also, the hemolysis of hemosome and hemosome/blood mixed solution was measured less than normal red blood cell. Therefore, the oxygen transfer rate showed high use of hemosome, and hemosome/blood mixed solution rather than normal blood. Because microen- capsulation of normal red blood cells prevent hemolysis of normal red blood cells.
혈관 내 폐 보조장치에서의 산소전달속도 예측에 관한 연구
김기범,나도춘,김성종,정인수,정경락,권대규 한국막학회 2004 멤브레인 Vol.14 No.1
본 연구의 목적은 정맥 내 폐 보조장치 설계에 있어서 기체전달을 예측하기 위하여 혈관 내 폐 보조장치를 정맥 내에 삽입하기 전, 여러 가지 설계조건에서 실험적 모델링을 통하여 예측식을 찾고자 시도하였다. 실험결과 중공사 충진율의 함수에 따라 기체전달을 예측할 수 있었다. 실험에 의하여 얻어진 기체전달은 예측식에 의한 기체전달과 유사하여, 식에 대한 신뢰성을 얻을 수 있었다. 그러므로, 중공사의 충진율의 함수에 따라 기체전달을 예측할 수 있으며, 혈관 내 폐 보조장치의 기체전달을 예측하는데 매우 유용하였다. The purpose of this paper was to find out the proper equation to predict the gas transfer rate for designing intravenous artificial lung assist device. The prepared hollow fiber modules were examined under various experimental conditions through experimental modeling before inserted the artificial lung assist device into as venous. As a result, we can estimate the gas transfer as a function of the packing density. The gas transfer obtained from the experiment was similar to that from the equation, confirming the usefulness equation. Therefore, we can conclude the gas transfer of the intravenous artificial lung assist device as a function of the packing density, and this functions are very useful for predicting the gas transfer of the intravenous artificial lung assist device.
김기범,나도춘,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-
We intended to develope an vibrating intravascular lung assist device(VIVLAD) in order to exchange of efficiently gas transfer of oxygen and carbon dioxide exchange requirements for end-stage acute respiratory distress syndrome (ARDS) patients. However, the clinical study, concluded that more gas exchange was needed for intravascular oxygenation to be clinically effective in ARDS treatment. In this study, we tried to enhance gas exchange on the VIVLAD by using microencapsulation of hemoglobin, as the microencapsulation of hemoglobin reduces blood hemolysis, and perfluorocarbon emulsion(PFC emulsion). As a result, it was shown that the oxygen transfer of hemosome and blood/hemosome mixed solution were higher than that of whole blood. Also, it showed that the carbon dioxide transfer of whole blood/PFC emulsion mixed solution was higher than that of others. Therefore, we determined that hemosome and PFC emulsion could increase oxygen transfer and carbon dioxide transfer, respectively.