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대상포진 환자에서 Varicella - Zoster 바이러스의 분자생물학적 분석
나건연 ( Gun Yeon Na ),정상립 ( Sang Lip Chung ),김정철 ( Jung Chul Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4
Background : Chicken pox and herpes zoster are caused by the varicella-zoster virus(VZV). To investigate the epiderniologial relationship between clinical isolates of VZV, it is essential to distinguish different isolate. Objective : This study was conducted to classify the VZV strains according to R5 tandem direct reiterations(TDR) copy numbers and Pst I endonuclease cleavage site mutation, and to analyze the distribution pattern of VZV strains isolated in Korea. Methods : Strains of VZV were isolated from 61 patients with herpes zoster who had not been immunized with a live vaccine of VZV. Copy numbers of R5 TDR which was located in variable region IV were measured by PCR. The presence of a Pst I cleavage site in a middle portion of the long unique region of VZV genome was analyzed by PCR thereafter restriction enzyme digestion(PCR-RFLP). Results : VZV strains isolated in Korea contained one to three copy numbers of R5 TDR. Of 61 isolates, 43(70%) comtained 2 copies of R5 TDR, while 11(18%) isolates contained only one copy and 7(12%) isolat s contained 3 copies. About 16% of the strains examined did not have a PstI cleavage site, although the majority of strains retained this site. VZV strains could be classified into 6 strains on the basis of the copy number of R5 TDR and PstI cleavage site, in which the strain with 2 copies of R5 TDR and PstI cleavage site positive was the most frequent type (36 out of 61 isolates) in Korea. Four batches of live attenuated vaccine(Biken) that is now used in Korea showed 2 copy numbers of R5 TDR and PstI site negative. Conclusipn : The copy number of R5 TDR and the presence of PstI cleavage site seems to be a reliable marker for dicrimination of VZV strains in Korea. This discrimination can be used to study the molecular epiclemiology of VZV and as a criterion for identification of vaccine-related isolates. (Kor J Dermatol 1995;33(4): 616-624)
나건연 (Gun Yeon Na) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1
Background: The life span of leprosy patients was shorter than general populations prior to sulfone therapy. Objective : This study set out to determine the life length of leproy patients in comparison with general populations. Methods : The subject of th
나건연(Gun Yeon Na),최성관(Sung Kwon Choi),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.6
A 5-month-old male infantshowed greasy sealy papules on the scalp, dirty scaly papules on the trunk and scaly petechial papules on both the palms and soles since birth. When admitted to the hospital, the patient exhibited lymphadenopathy, hepatomegaly, abdominal distension, mild fever and skin eruption. The biopsy specimens from the skin and lymph node showed an infiltrate composed almost entirely of histiocytic cells with irregularly shaped nuclei and abundant, well demarcated cytoplasm. The histiocytic cells of the infiltrate were proved as Langerhans cells by electron microscopic examination and S-100 protein study. He was treated with methotrexate 30mg/m twice a week and prednisolone 40mg/m daily. Initially skin lesions and general condition were improved, but the patient expired. due to septicemia after 3 months.
나건연(Gun Yeon Na),최성관(Sung Koan Choi),정상립(Sang Lip Chung),전재복(Jae Bok Jun) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.5
Cutis verticis gyrata is a morphologic term, typically occurring on the scalp, characterized by eleuated, folded convolutions of the scalp, which may be either secondary to local disease in the scalp, or primary(idiopathic) disease. This case report was a 33-year-old woman, teacher. A birth, the patient had a small, round, soft, convoluted mass on the right parietal scalp. The mass slowly enlarged in size with the same rate of body growth. Now, the lesion is 15*13cm in size, well demarcated, oval shaped, soft, convoluted mass with overlying normal skin colored or hyperpigmented macules. Light rnicroscopic findings of the skin kesion showed deeper extension of the nevus cells into the dermis and subcutis, which presented as an intradermal nevus, Electron microscopy showed that the nevus cell had an indented nucleus and numerous mitochondrias and melanosomes in the cytoplasm.
서선교 ( Seon Kyo Seo ),나건연 ( Gun Yeon Na ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
An 80-year-old woman was admitted because of ag avation of preexisting dyspnea and was refened to the dermatology deparbnent for evaluation of three tender nodules on her extremitiom. A chest X-ray and CT scan suggested pulrnonaxy tuberculosis wikh an endobromchial sprtad, Her past medical histary showed congeative heart failure, treated pulmonery tuberculosis and corticstertoid medication for arthralgia. Acid-fast bacilli were observed in tissue smears and a biopsy specimen. Mycobacterium tubereulosis was recovered from cultures. We suggest that this case was a tuberculous gumma following pulmonary tuberculosis and that a tissue or pus smear for acid-fast bacilli is a very useful diagnostic toal in tuberculous gumma because tubercle bacilli are copious in numbcr. (Korean J Bermatol 1998;36(5): 956-958)
박동재 ( Dong Jae Park ),오병민 ( Byung Min Oh ),이석종 ( Seok Jong Lee ),나건연 ( Gun Yeon Na ),김도원 ( Do Won Kim ),정상립 ( Sang Lip Chung ),곽은경 ( Eun Kyung Kwak ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4
Neuroendocrine carcinoma is known to have features of neuroendocrine and epithelial differentiation through immunochemical and biochemical investigation and Merkel cell carcinoma is a rare primary malignancy of the skin belonging to the broad spectrum of tumors of the neuroendocrine system. Small cell carcinoma of uterine cervix, also a kind of neuroenodcrine carcinoma, is rarely reported and it is much more exceptional in the world that cervical carcinoma metastases to distant skin. Further more this may be the first case of a uterine neuroendocrine carcinoma metastasizing to the skin in Korean medical literature. We report a case of 74-year-old woman who presented with a somewhat fixed subcutaneous nodule measuring 2.5 ㎝ × 0.8 ㎝ on the left side of forehead. A biopsy of the nodule revealed a poorly differentiated carcinoma under the muscle without involvement of upper structures and it showed neuroendocrine differentiation by immunohistologic studies. Before appearing as cutaneous manifestation 2 months ago, she had showed a history of abnormal vaginal bleeding and diagnosed as a cervical neuroendocrine carcinoma, especially small cell carcinoma histologically. (Korean J Dermatol 2003;41(4) : 484-488)
민감성 피부에 대한 통계적 관찰과 젖산 자상 검사를 이용한 주관적 자극의 평가
류효섭(Hyo Sub Ryu),김도원(Do Won Kim),이석종(Seok Jong Lee),나건연(Gun Yeon Na),정상립(Sang Lip Chung) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8
N/A Background : Sensitive skin has been described as a skin type showing higher reactivity than normal skin and developing exaggerated reactions when exposed to internal stimulants and external irritants. The lactic acid sting test is widely accepted as a marker of sensitivity and employed for the selection of subjects experiencing invisible sensory irritation. Objective : To carry out an epidemiological study to assess the prevalence and possible related factors of sensitive skin in a regional population, and to examine the relationship between sensitive skin and subjective irritation using the lactic acid sting test. Methods : A total of 514 people responded to self-assessment questionnaires composed of questions about the self-perception, related factors, symptoms and signs of sensitive skin, We assessed subjective irritation using the lactic acid sting test in 54 volunteers. Results : The results are summarized as follows 1. The incidences of self-reported sensitive skin were 55.7% for woman, 38.9% for men and 51.0% for all responders. 2. The family history and seasonal variation of sensitive skin were significantly more common in sensitive skin group. 3. The face especially the cheek area was the most sensitive portion of body, cosmetics were common irritants. 4. The lactic acid stinging scores were significantly higher in the sensitive skin group. Conclusion : Our survey indicated that sensitive skin is a common problem for people and a complex problem with genetic, individual, environmental implications and the lactic acid sting test is a valuable method to define skin sensitivity.
염정섭(Jung Sub Yeum),신동주(Dong Ju Shin),서선교(Seon Kyo Seo),나건연(Gun Yeon Na) 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.12
N/A A total of 748 newborns delivered at the Fatima Hospital, Taegu, Korea, over period of 8 months were examined for the presence of skin lesions within 48 hours of birth. The frequencies of the type of birthmarks were: salmon patch, 61.8%; portwine stain, 0.7%; mongolian spot, 99.1%; cafe-au-lait spot, 0.5%; congenital nevomelanocytic nevus, 0.5%; milia, 44.5%; sebaceous hyperplasia, 76.9%; nevus sebaceus, 0.9%; erythema toxicum neonatorum, 29.3%; genital hyperpigmentation, 49.7%. Erythema toxicum neonatorum was less common in premature infants and more frequent on the second day of life than first one. Genital hyperpigmentation was observed predominantly in the male neonate. There was positive relationship between genital hyperpigmentation and birthweight. (Korean J Dermatol 2001;39(12):1377~1382)