Trend Report - 에너지 절감량 산정을 위한 M&V기술 - IPMVP 적용 로드맵

김진상,Kim, Jin-Sang 에너지절약전문기업협회 2013 esco Vol.81 No.-

기니픽에서 갑상선, 간 및 신기능에 미치는 납과 selenium의 상호관계

김진상,강형섭,강창원,Kim, Jin-sang,Kang, Hyung-sub,Kang, Chang-won 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.3

This study was designed to examine the involvement of lead in function of target organ, and the protective effect of selenium in lead-treated guinea pigs for 8 weeks. The effects of exposure to 0.5% lead acetate(lead) and/or 4ppm sodium selenite(selenium) in feed on serveral aspects were evaluated by measuring thyroid stimulating hormone(TSH), triiodothyronine($T_3$), thyroxine($T_4$), serum biochemical activities, organ weights, and serum and organ lead concentrations in growing animals. The many indicators of endocrine function(TSH, $T_3$, and $T_4$ in serum), enzyme and biochemical activities(${\alpha}$-glutamyltranspeptidase, alkaline phosphatase, lactate dehydrogenase, triglyceride, creatinine, $Ca^{2+}$ in serum), and organ weights(kidney, spleen and testis) were correlated with lead exposure or showed significantly different mean values between the exposed and controls. These changes on some aspects were reversed by combination-fed of selenium, but did not statistically significant. The organ(kidney, liver, spleen, testis and brain) and serum lead concentrations of lead-fed group were clearly higher than that of controls. Selenium supplementation resulted in a significant protection against lead accumulation in liver and testis. These results suggest that lead can cause a toxic effect on several organ and that selenium seems to has a protective effect on specific reaction by lead-induced organic function toxicity.

의료용 전문가 시스템에서 추론에 관한 연구

김진상,신양규,Kim, Jin-Sang,Shin, Yang-Kyu 한국데이터정보과학회 1999 한국데이터정보과학회지 Vol.10 No.2

본 논문에서는 의료용 전문가 시스템에 사용 가능한 의료지식을 수리논리적으로 표현하고 이에 대한 연역 및 진단추론을 행하는 방법을 제시하였다. 문제해결을 위해서는 연역추론을 행하며 원인의 규명을 위해서는 진단추론을 행하지만 일차논리 언어로 표현된 의료지식에서 두 종류의 추론을 병행할 수 있다. 그리고 의료지식에 자주 발생하는 시간에 따라 가변적인 결과의 추론방법도 함께 고찰하였다. We investigate a logical approach to represent medical knowledge, reason deductively and diagnostically. It is suggested that medical knowledge-bases can be formulated as a set of sentences stated in classical logic where each sentence reflects a doctor's knowledge about the human anatomy or his/her view of patient's symptoms. It is also suggested that a form of temporal reasoning can be captured within the same framework because each sentence can have a different truth value based on time. We apply our logical framework to formalize diagnostic reasoning, where the primary cause of illness is chosen among the set of minimal causation on the basis of abductive hypotheses. Most of our examples are given in the context of medical expert systems.

가토(家兎)에서 nitrite에 의한 methemoglobinemia에 미치는 selenium의 영향(影響)

김진상,한정희,김기수,Kim, Jin-sang,Han, Jeong-hee,Kim, Kye-soo 대한수의학회 1991 大韓獸醫學會誌 Vol.31 No.1

The protective of influences of sodium selenitc ($Na_2SeO_3$) against the methemoglobinemia with sodium nitrite were investigated on hemoglobin, methemoglobin, glutathione peroxidase and NADH-methemoglobin reductase activity in rabbits which were given 0,1,3 and 9ppm sodium selenite of drinking water for a week. Dietary selenium did not alter total hemoglobin in the blood of rabbits. Selenium was found to decrease nitrite-induced methemoglobin in a dose-dependent manner. The glutathione peroxidase activity was also increased by selenium in all the experimental groups. However, the NADH-methemoglobin reductase activity by selenite did not show significant differences as concerns the methemoglobinemia. These results showed that selenium could inhibit nitrite-induced methemoglobinemia. Its influence of inhibition is suggested that the effect of the reduction of methemoglobin was greatly stimulated by glutathione peroxidase activity.

한국재래산양의 전지골격에 관한 해부학적 연구

김진상,이흥식,이인세,Kim, Jin-sang,Lee, Heung-shik S.,Lee, In-se 대한수의학회 1987 大韓獸醫學會誌 Vol.27 No.2

The anatomical structure of the Skeleton of thoracic limb of thirty-one adult Korean native goats(body weight: 14~17kg) was observed after skeletal preparation, and the osteometry was performed in each bone. The results were as follows; 1. The thoracic limb of the Korean native goat was composed of scapula, humerus, radius, ulna, carpal bones, metacarpal bones, phalanges and sesamoid bones. 2. The scapula was flat and triangular in shape. There were no distinct tuber of spine and acromion in the spine. The subscapular fossa was deep and triangular in shape and the vertebral border was sigmoid form. The coracoid bone was formed as the coracoid process at the medial aspect of the supraglenoid tubercle but the clavicle wa.s not observed. The left and right scapular indexes were 57.92 and 58.31 and the glenoid cavity indexes were 89.23 and 86.82, respectively. 3. The greater tubercle of the humerus was devided into cranial and caudal parts. The third tubercle was observed and the face for the infraspinatus muscle was rectangular form. The left and right humerus indexes were 32.44 and 32.63, the head indexes were 94.13, 96.62 and the trochlear-epidondyle indexes were 67.32 and 65.81, respectively. 4. The radius and ulna were fused entirely except at the broad proximal and narrow distal interosseous spaces. The ulna was longer than the radius, and its reduced body and distal end were fused at the caudomedial surface of the radius. 5. The carpal bones were six in number. There were radial, intermediate, ulnar, accessory, second-third and fourth carpal hones in carpal bones. 6. The metacarpal bone was composed of a large metacarpal bone resulted from the fusion of the third and fourth metacarpal bones, and there was a metacarpal tubercle at the dorsolateral part of the proximal end. There were no vestiges of the second and fifth metacarpal bones. 7. The digits were composed of third and fourth digits and each digit was composed of the proximal, middle and distal phalanges. 8. The sesamoid bones were six in number. There were two at the fetlock joint and one at the coffine joint palmarly in each digit. 9. The ratios of the lengths among the scapula, humerus, antebrachium and metacarpal bone were 1.42 : 1.47 : 1.77 : 1.00 in the left and 1.42 : 1.45 : 1.77 : 1.00 in the right, respectively.

Guinea pig에서 alcohol과 paraquat에 의한 갑상선 독성에 미치는 selenium의 방어 효과

김진상,강형섭,Kim, Jin-sang,Kang, Hyung-sub 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.1

This study examined the effect of alcohol(AL) and/or paraquat(PQ) on serum TSH, thyroid hormones and enzyme activities, and the protective effect of selenium(SE) againse alcohol and/or paraquat-induced thyroid toxicity in guinea pigs. The experomental group consisted of control, 15% alcohol(AL), 4ppm sodium selentite(SE), 200ppm paraquat(PQ), AL+PQ, AL+SE, PQ+SE and AL+PQ+SE mixed in drinking water-fed guinea pigs for 4 weeks. The morphological changes of thyroid gland were studies on paraffin-embedded sections stained with H-E stain. Body weight losses, high serum concentration in TSH and cholesterol, and low values on triiodothyronine($T_3$), thyrozine($T_4$), free $T_4$ and alkaline phosophatase(ALP) were produced in the groups fed AL and/or PQ. We also noted that AL+PQ-fed group was marked increase in serum TSH. In AL or AL+PQ-fed groups when cpmpared to control group had increased the ratio of thyroid weight to body weight(ratio Twt/Bwt), whereas the ratio Twt/Bwt was decresed in SE or PQ-fed groups. However, the serum TSH, $T_3$,$T_4$ free $T_4$ and cholesterol values, and the ratio Twt/Bwt were reversed in groups given the combination of SE, compared with AL and/or Pq-fed groups, also ALP values were reversed in groups given the combination of SE, compared with AL or AL+PQ-fed groups. In microscope, morphological changes showed a remarkable between the AL or PQ-fed group and controls. In AL+PQ+SE-fed guinca pig, follicular colloid is high density in thyroid follicle and increased in connective tissue around the thyroid cells, and thyroidal epithelia were composed of cuboidal or columnar epithelium. The indicated that the morphological changes of thyroid were direct action in the thyroid cell. The results of this study confirmed that the toxic effect of AL or PQ on thyroid occur independently of changes in liver function, and that SE confers marked protection against AL or PQ-induced thyroid toxicity.

한국재래산양의 후지골격에 관한 해부학적 연구

김진상,이흥식,이인세,윤여성,Kim, Jin-sang,Lee, Heung-shik S.,Lee, In-se,Yoon, Yeo-sung 대한수의학회 1988 大韓獸醫學會誌 Vol.28 No.1

The anatomical structure of pelvic limb, of thirty-one adult Korean native goats (Body weight: 14~17kg) was observed after skeletal preparation, and the osteometry was performed in each bone. The results were as follows: 1. The pelvic limb of the Korean native goat was composed of the hip bone, femur, patella, tibia, fibula, tarsal bones, metatarsal bone, phalanges and sesamoid bones. 2. The hip bone consisted of the ilium, ischium and pubis which fused each other, The gluteal surface of the ilium was directed dorsolaterally. The tuber sacrale and tuber coxae were formed at the dorsal apex and ventrolateral part of the iliac wing, respectively. The lesser ischiatic notch was deeper than the greater one. The ischiatic tubercles were triangular form and consisted of the dorsal, lateral and caudal ischiatic tubercles. The left and right hip bone indexes were 67.08, 66.20, the acetabular indexes were 93.78 and 92.10 and the obturator foramen. indexes were 53.84 and 54.77, respectively. 3. In femur, both of the greater and lesser trochanter were well developed but the third trochanter was not observed. The left and right femur indexes were 26.55 and 26.14, head indexes were 81.66 and 81.49 and the trochlear-epicondyle indexes were 42.47 and 41.63, respectively. 4. The patella was observed as an isosceles triangle with base lying proximal and the cranial surface was more convex. 5. The tibial shaft was sigmoid form and the popliteal notch was deep. There was a large nutrient foramen at the cranial aspect of the cranial intercondylar area. The tibial indexes were 22.09 in left and 21.10 in right. 6. The proximal extremity of the fibula was fused with the lateral condyle of the tibia but the distal one was observed independently as the malleolar bone. 7. The tarsal bones were five in number; the talus, calcaneus, centroquartal tarsal bone, first tarsal bone, and second-third tarsal bone. 8. The metatarsal bone was composed of a large metatarsal bone. resulted from the fusion of the third and fourth metatarsal bones, The structure of metatarsal bone was similar to the metacarpal bone but longer about 7mm. 9. The phalanges and sesamoid bones were similar to these of the thoratic limb. 10. The ratios of the lengths among the hip bone, femur, tibia and metafarsal bone were 1.71 : 1.54 : 1.73 : 1.00 in left and 1.68 : 1.53 : 1.72 : 1.00 in right, respectively.

저농도 일산화탄소가 흰쥐 미상핵에 미치는 영향에 관한 조직화학적 연구

김진상,Kim, Jin-sang 대한수의학회 1989 大韓獸醫學會誌 Vol.29 No.4

This study was undertaken to investigate the changes of enzyme activities resulted from low concentrated carbon monoxide poisoning on the caudate nucleus in rat. The activities of cytochrome oxidase, succinate dehydrogenase and lactate dehydragenase were observed histochemically, after the experimental animals were poisoned to 100ppm carbon monoxide for 8 hours every day from one day to 16 days. The materials were sliced from coronal section at the level of the optic chiasm and immediately frozen sections of $10{\mu}m$ thickness were cut on the cryostat at $-15^{\circ}C$ and incubated in the medium containing substrate for histochemical detection of cytochrome oxidase, succinate dehydrogenase and lactate dehydrogenase. The sections were mounted in glycerol gelatin and observed under light microscope. It was obtained that cytochrome oxidase activity decreased moderately and succinate dehydrogenase activity showed marked or moderate activity during entire poisoning period and lactate dehydrogenase activity showed marked or moderate activity from one to 8 days but recovered to normal condition at 16th day.

불완전한 지식에서 정리증명을 위한 확률추론

김진상,신양규,Kim, Jin-Sang,Shin, Yang-Kyu 한국데이터정보과학회 2001 한국데이터정보과학회지 Vol.12 No.1

본 논문은 논리문장으로 표현된 지식을 처리하는 정리증명 과정에서 증명이 완료되기 전에 잠정적 결론을 유도하는 확률추론 기법을 제시한다. 정리증명 과정 중에 베이지안 해석을 이용하여 지식을 갱신하는 방법을 제시하고, 의사결정 방법을 사용하여 시간에 민감한 사안에 대해 신속하게 대처할 것인지 아니면 고의로 미룰 것인지를 결정하는 방법을 밝힌다. We present a probabilistic reasoning method for inferring knowledge about mathematical truth before an automated theorem prover completes a proof. We use a Bayesian analysis to update beleif in truth, given theorem-proving progress, and show how decision-theoretic methods can be used to determine the value of continuing to deliberate versus taking immediate action in time-critical situations.

열전 에너지 변환원리 및 열전소재 개발 현황

김진상,Kim, Jin-Sang 한국전기전자재료학회 2008 전기전자재료 Vol.21 No.7