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      저자 : 김진규(Jin Kyn Kim) (검색결과 2 건)
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      • KCI등재

        쇠비름 수침액이 방사선 조사에 의한 생쥐의 생존율과 뇨중 아미노산 조성에 미치는 영향

        천기정(Ki Jung Chun),김진규(Jin Kyn Kim),이영근(Young Keun Lee),김봉희(Bong Hee Kim) 대한약학회 1999 약학회지 Vol.43 No.2

        A study has been conducted to investigate the radioprotective effects of purslane extracts (P) when I.p. injected before irradiation (R). For studying the amino acid composition, three groups of ICR mice (7-week-old) were tested. The first group I.p. injected with purslane extract for 5 days were irradiated with 6 Gy of gamma-radiation (P+R). The second group was irradiated with 6 Gy without any pretreatment (R). The third group was non-irradiated control (CT). Each group divided into two groups for the survival rate study, one injected with saline (S) and the other injected with purslane extract (P) for five days and then irradiated with 8 Gy. The amino acid composition of urine samples were analyzed with HPLC for 19 days after irradiation. A few kinds of amino acids such as lysine and methionine in urine from P+R group increased in comparison with those from CT or R group. The survival rate of P group maintained much higher than that of S group during experimental period. The results obtained may support that this plant has radioprotective substances by means of life-lengthening, not of urine amino acid components.

      • KCI등재

        감마선에 조사된 생쥐에 있어서 방사선방어효과 평가를 위한 생물학적 파라메타

        천기정(Ki Jung Chun),김봉희(Bong Hee Kim),이영근(Young Keun Lee),김진규(Jin Kyn Kim) 대한약학회 1999 약학회지 Vol.43 No.2

        This study deals with the biological changes in mice after gama-irradiation. Four weeks old BALB/c mice were irradiated with 6.5Gy of gamma-ray on the fifth day after oral administration of radioprotectants such as ascorbic acid, tocopherol and cysteine. Control group was irradiated with 6.5Gy without pre-administration of radioprotectors. Blood cells and sperm cells were counted and body, testis and spleen were weighed 3 days after irradiation. And also liver antioxidant activity and range of spleen immune cells were measured. Differences in most biological parameters were not clearly distinguished between experimental groups. However, the relative spleen weight, the relative testis weight and the population size of spleen immune cells such as T helper cells, B cells and macrophages measured by means of FACS showed significant difference between irradiated and radioprotectant administered group. It is concluded that the relative spleen weight, the relative testis weight and the population size of spleen immune cells are easy and useful parameters for assessing the effect of radioprotective substances and for quantifying biological damage of radiation, as well.

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