장막하 낭포성 자궁근종의 1 례

김종화(JH Kim),장상호(SH Chang),진건(K Jin),장윤석(YS Chang) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.2

Cystic degeneration is a rather common secondary change of myoma. In extreme cases, all of the original tumor is involved, being converted into a large cystic cavity, simulating ovarian cysts. We presented the case with a brief review of the literature.

생쥐 하수체 성선자극호르몬 분비세포의 개체발생 및 임신기간에 따른 변화에 관한 연구

김종화(JH Kim),이진용(JY Lee) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10

This study was carried out to localize the FSH cells and LH cells in mice pituitaries , to investigate the ontogenesis of these cells , to classify the FSH cells and LH cells , to detect the immunoreactive sites in these cells , and to see the morphological cnanges of these cells in the pituitaries of the female mice at electron microscopic levels. Fifteen BALB/c female mice and 50 BALB/c fetal mice were used in this study. The avidin-biotin peroxidase complex ( ABC ) method was used for the immunohistochemical study of fetal mice pituitaries and the immunogold method was used for the immunocytochemical study of fetal and adult mice pituitaries. FSH cells and LH cells were localized in the pars distalis of pituitaries of all mothers and some fetuses. FSH cells and LH cells were first detected on the 17th day of gestation at the light and electron microscopic levels. FSH cells and LH cells showed significant increase in number during the late developmental period by immunohistochemistry. Immunoracctive stainings were detected only in the secretory granules in FSH cells and LH cells at the electron microscopic level. FSH cells and LH cells could be classified into Type I cells ( which were round and contained evenly distributed large secretory granules ). Type II cells ( which were angular and contained loosely distributed , small and medium-sized granules ) and Type III cells ( which were angular and contained peripherally distributed small secretory granules ) by their morphology. Type I FSH cells were abundant in midpregnanyc and term , and Type III FSH cells increased in percentage on the 15th and 17th day of gestation. Type I LH cells Type II FSH cells and Type II LH cells showed no significant changes in percentage during pregnancy.

정상생리주기의 불임여성에서 초기 난포기에 측정된 성선자극호르몬 및 Estradiol혈중치의 연령에 따른 차이

김완영(WY Kim),박재기(JK Park),이종학(JH Lee),김종화(JH Kim),백원영(WY Paik) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.2

Throughout a womans reproductive life there is a close relationship between the activity of the ovary and that of the hypothalamic-pituitary axis. As the menopause approaches this relationship becomes progressively disturbed. During the peri-menopause the deficiency of ovarian hormones is thought to disturb the function of the hypothalamic-pituitary axis from ovarian control, resulting in the high levels of FSH and LH found in postmenopausal women. There has been known that the change of serum levels of gonadotropin and estradiol precede the menopause and is related decreasing tendency of pregnancy rate. The aim of this study was to determine the effect of age on the serum levels of FSH, LH, estradiol in infertile women with regular menstrual cycle. Seventy-four infertile womne were evaluated according to their ages classified into 5 groups as well as control I(18-24 years old) and control II (45-55 years old)(Group I; 21-24 years old, Group Ii 25-29 years old, Group III: 30-34 years old, Group IV: 35-39 years old, Group V: 40-44 years old, respectively). 1. The mean serum levels of FSH, LH, and estradiol in control I during their early follicular phase were 10.11 mIU/ml, 6.29 mIU/ml, 39.04 mIU/ml, respectively. 2. The levels of FSH and LH were significantly higher than those of control I or all infertile groups (p0.05). 5. The mean levels of estradiol (E2) in infertile groups during their early follicular phase were 37.77 pg/ml, 35.42 pg/ml, 44.68 pg/ml, 74.53 pg/ml, 63.99 pg/ml, respectively and there were no significant difference among the levels of estradiol in infertile groups(p>0.05). 6. The LH/FSH ratio in all infertile groups and normal control groups were 0.78 , 0.83, 0.63, 0.74, 0.46, 0.66, respectively and the LH/FSH ratio in group V was significantly lower than those of group I, II(p0.05).

금강초롱꽃의 자생지 식생 및 생육조사

임학태(Lim HT),김종화(Kim JH),김정기(Kim JK),이우철(Lee WT),유기억(Yoo KO),김원배(Kim WB),김병현(Kim BH),김정간(Kim JK) 한국원예학회 1993 한국원예학회 학술발표요지 Vol.11 No.2

심장기형과 폐기형을 동반한 Meckel-Gruber Syndrome 1 례

한성천(SC Han),최원준(WJ Choi),김진성(JS Kim),신반철(BC Shin),김규현(KH Kim),이종학(JH Lee),김종화(JH Kim),백원영(WY Paik) 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.9

The major features of Meckel-Gruber Syndrome are occipital encephalocele, postaxial polytactyly, and polycystic kidneys. This syndrome is lethal and its cause is still unknown due to rarity. At present, autosomal recessive is thoughth to be as one of the causes. The importance of recognizing this sysdrome is the high risk of recurrence (one in four)in future pregnancies. A case of Meckel-Gruber Syndrome combined cardiac anomaly and pulmonary anomaly of very lower incidence is presented with a brief literature review and autopsy.

Nitric Oxide가 사람 자궁평활근의 수축-이완에 미치는 영향 및 그 작용기전에 관한 연구

이종학(JH Lee),박신근(SK Park),이순애(SA Lee),김종화(JH Kim),백원영(WY Paik),정원석(WS Chung),장기철(GC Jang) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.8

The purpose of this study was to establish whether endogenous L-arginine/nitric oxide(L-ARG/NO) pathway system exists in human uterine smooth muscle and this muscle is responsive to exogenous nitric oxide(NO). The differences of the effect of NO on myometrial contractility between pregnant and non-pregnant uterus were also observed. Isometric tension of human myometrial strips from pregnant(n=10) and non-pregnant(n=20) women were measured in vitro in response to L-arginine(L-ARG), N-nitro-L-arginine methyl ester(L-NAME), or Nw-nitro-L-arginene(L-NNA) that modulate endogenous L-ARG/NO action as well as to exogenous NO that is generated by photolysis of NO-carrying compound such as streptozotocin(STZ). Changes of amplitude and cycle length of phasic contraction by photolysis of STZ with various concentration were measured and compared between pregnant and non-pregnant uterus. Cyclic guanosine monophosphate(cGMP) levels were measured by radioimmunoassay in various testing conditions of myometrial tissues. Spontaneously contracting non-pregnant myometrial strips were relaxed by application of L-ARG(10-3mol/L). This L-ARG-induced relaxation was obliterated by application of L-NAME(10-3mol/L). These L-ARG- or -L-NAME-induced effects were exagerated in the lipopolysaccharide(10 micro g/ml)-pretreated or pregnant myometrium. The non-pregnant myometrial contractile activity was decteased by exogenous NO dose-dependently, that is, by photolysis of the STZ with the concentration of 10-6, 10-5, 10-4, and 10-3 mol/L, the mean percent decrease of amplitude were 8.3%, 15.8%, 26.4%, and 45.7%, respectively and the mean percent delay of cycle length were 14.3%, 24.5$, 48.8%, and 120.6%, respectively. These mean percent changes of amplitude and cycle length under the same dose of STZ(10-4 mol/L) were greater in pregnant myometriums compared with non-pregnant ones(26.4% vs 50.5%, 48.8% vs 73.3%, mean +- SD, p

자궁선근증에 대한 임상 몇 병리학적 고찰

김학순(HS Kim),김종화(JH Kim),강순범(SB Kang) 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.1

자궁선근증 , 임상 몇 병리학적 고찰 The clinical study was performed to 311 patients with adenomyosis among 1324 patients who were undertaken total hysterectomy in the department of Gynecology, Seoul National University Hospital, during July 1983 and February 1985. For comparison 1013 patients without adenomyosis were selected for control group among the same 1324 patients. The results were summarized as follows: 1. The incidence of adenomyosis was 23.5%(311/1324). 2. The patients with adenomyosis in the fifties were 179(57.6%), peak in incidence and statistically significant compared to control group (P*<0.01). 3. Parity was 3.05 in average and 295 patients(94.9%) were parous(p*>0.10). 4. Frequency of artificial abortion was 3.32 in average ande 267 patients(85.9%) experienced more than one (p*<0.01). 5. Frequency of spontaneous abortion was 0.43 in average and 92 patients(26.4%) experienced more than one (p*=0.03). 6. There was no significant relationship between the incidence of adenomyosis and previous laparotomy including cesarean section. 7. Menstrual disturbances were present in 243 patients(78.8%) and the duration of symptoms was below 6 months in about half. 8. Preoperatively adenomyosis was suspected in 25 patients(8.0%), especially up to 15.0% in uncomplicated adenomyosis. 9. The associated pathology was leiomyoma(34.1%), pelvic endometriosis(6.8%, p*<0.01) and endometrial adenocarcinoma(1.0%, p*>0.10). etc. 10. Uterus was enlarged significantly in patients with "adenomyosis without myomas" and mean uterine weight is 159gm (p*<0.01). 11. Endometrial findings were proliferative phase 41.1%, secretory phase 32.5%, and hyperplasia 3.2%, etc. 12. There was no statiscally significant difference between uncomplicated and complicated adenomyosis.

점액성 난소종양에 동반된 육종양 내벽결절 1 례

박재기(JK Park),김종화(JH Kim),김완영(WY Kim),이종학(JH Lee),백원영(WY Paik),고경혁(KH Ko) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.2

The solid mural nodules within the musinous ovarian tumors are extremely rare and to date about 30 cases have been reported in the literature. But these cases have not been yet reported in Korea. Pathologically mural nodules of anaplastic carcinoma and true sarcoma may be confused on both gross and microscopic examimation with sarcoma-like nodules. The differenciation between these lesions have a prognostic significance because of the favorable prognosis of sarcoma-like mural nodules. We report a case of mucinous ovarian tumor with a carcoma-like mural nodule in a 18 year old nulliparous woman.

심장판막이식과 수술후의 임신에 관한 임상적 고찰

이재관(JK Lee),김종화(JH Kim),강순범(SB Kang),김종환(JW Kim),서경필(KP Suh) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.8

Patients who have had cardiac valve replacement are being seen increasingly often as candidates for antenatal care. The outcome of 23 pregnancies in 14 patients with bioprosthetic cardiac valves is analyzed and reported here. The results were summarized as follows: 1. Twenty three pregnancies in 14 patients with bioprosthetic cardiac valves resulted in 11 healthy, 2 low birth weight infants, 2 spontaneous abortions, 7 elective terminations of pregnancy, and one tubal pregnancy. 2. Pregnancy and labor seemed to have been tolerated relatively well in these patients. 3. There were 3 males and 10 females among the 13 infants born. 4. Birth weights ranged from 2,140 to 3,670g(mean 3,030). 5. Apgar scores at five minutes ranged from 4 to 10 (mean 9.1). 6. There were no instances of congenital malformations, maternal or fetal hemorrhagic complications. 7. There were 4 spontaneous vaginal deliveries, 7 elective vacuum extraction deliveries, 1 elective forcep delivery, and 1 cesarean section. 8. All patients received prophyllactic broad-spectrum antibiotics for infective endocarditis, and no nistances of endocarditis developed. 9. There were no stillbirth, no neonatal deaths, and no maternal deaths. 10. There were 2 instances of thromboembolism; one in the immediate postoperative period, and the other 5 years after valve replacement. All seemed to be unrelated to pregnancy. 11. Anticoagulants were not used in pregnancies which went to term except one patient, in whom coumarin was administered until 6th week of gestation. 12. One pregnancy was complicated with premature labor, one with gestational edema, one with preexisting chronic active hepatitis, five with worsening of cardiac status (one of the five, with newly developed atrial fibrillation). 13. 34.8% of all pregnancies after cardiac valve replacement were unwanted ones, and at the same time preventable `risk factors`.

난소갑상선종의 1 례

강태길(TG Kang),김종화(JH Kim),한성천(SC Han),권성택(ST Kwon),이순애(SA Lee),이종학(JH Lee),백원영(WY Paik) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.7

Struma ovarii, an ovarian teratoma of which all or a large part is composed of thyroid tissue, is an uncommon tumor accounting for 2.7% of all ovarian teratomas. We reported a case of struma ovarii and review the literature concerning this tumor briefly.