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제2형 당뇨환자의 유산소능력과 말초동맥혈관기능, CRP(C-reactive protein)와의 관계
안기만(Ki-Man Ahn),김윤신(Yoon-Sin Kim),김종혁(Jong-Hyuck Kim) 한국생활환경학회 2012 한국생활환경학회지 Vol.19 No.2
The purpose of this study was to investigate the effect of aerobic capacity (VO₂peak) would ameliorate inflammatory, anti-inflammatory markers and vascular function in patients with type 2 DM. To compare the importance of different inflammatory markers and traditional risk factors in predicting peripheral vascular disease(PAD) in patients with Type 2 diabetes mellitus. Diabetes mellitus (DM), chronic inflammation and vascular function are strongly related to increased cardiovascular risk. The purpose of this study was to evaluate whether an aerobic capacity (VO₂peak) would ameliorate inflammatory, anti-inflammatory markers and vascular function in patients with type 2 DM. The subjects consisted 203 middle aged men who was aged 40-59 years were checked by blood test(including CRP), measurement of body fat, blood pressure, lipid profile, exercise stress testing and ABI. Aerobic capacity was determined in all individuals by measurement of maximal oxygen consumption during treadmill exercise. Control group VO₂peak were significantly high compared with type 2 diabetes mellitus patients group(p=0.01). This study show that VO₂peak levels are positively correlated with hsCRP (r=0.22) and ABI(ABI_R, r=0.137, ABI_L, r=0.86) in patient with type 2 diabetes mellitus. Higher physical conditioning status, indexed by VO₂peak was associated with reduced arterial stiffness. The results of our study suggest that high aerobic exercise capacity was associated with reduced arterial stiffness in type 2 diabetes mellitus.
건강한 중년남성에 있어 유산소 운동능력(VO₂ peak)이 맥파속도(Pulse wave velocity)와 CRP에 미치는 영향
안기만(Ahn, Ki-Man),김종혁(Kim, Jong-Hyuck) 한국체육과학회 2012 한국체육과학회지 Vol.21 No.1
The purpose of this study was to effect of the aerobic capacity on arterial stiffness and CRP in healthy adults. Experimental, epidemiologic and clinical studies have provided strong evidence that physical exercise has beneficial effects on multiple physiological variables affecting cardiovascular health. The subjects consisted 699 middle aged men who was aged 40-59 years were checked by blood test(including CRP), measurement of body fat, blood pressure, exercise stress testing and pulse wave velocity. Aerobic capacity was determined in all individuals by measurement of maximal oxygen consumption during treadmill exercise. VO₂peak significantly higher man was decreased hsCRP-0.1l4㎎/ℓ(p<0.002), PWV Right side-0.160(p<0.0001), PWV Left side-0.166(p<0.0001) and increased HDL-C levels 0.205(p<0.0001). These VO₂peak associated increases in HDL-C and decreased CRP levels and PWV. This study show that VO₂peak levels are positively correlated with hsCRP, HDL-C and PWV. Apparently healthy subjects with increased inflammatory markers have increased systemic arterial stiffness, which might reflect early atherosclerotic changes. Higher physical conditioning status, indexed by VO₂peak was associated with reduced arterial stiffness and hsCRP and increased HDL-C. The results of our study suggest that high aerobic capacity reduce hsCRP levels and improve PWV, HDL-C in healthy adult man.