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      • KCI등재후보

        장티푸스와 파라티푸스 30 예에 대한 임상적 고찰 및 Thiamphenicol 의 치료효과

        박창호(Chang Ho Park),김종서(Zong Suh Kim),남상숭(Sang Soong Nam),기세길(Se Kil Kee),윤덕구(Duk Koo Yun),송홍석(Hong Suck Song) 대한내과학회 1986 대한내과학회지 Vol.31 No.1

        N/A We reviewed 30 cases of bacteriologically con- firmed salmonellosis which performed hone marrow culture from March I984 to August 1985 at the Keimyung University. The results of study were as follows: Among 30 cases, paratyphoid A was 13 cases and group D typhoid fever was 17 case. Age distribution was from 16 to 63 years and most frequent in 2nd decade. Male to female ratio was 1: 3.3 in group A and 1: 1.4 in group D with female predominance. Clinical symptoms were fever, chill, general weakness, headache, anorexia, eneral ache in order of frequency and there was no difference in both group. Physical findings revealed abdominal tenderness in 14 cases(47%) and most common in right lower quadrant area. Splenomegaly was 3 cases(10%) and hepatomegaly was 4 cases(13%). Laboratory findings revealed anemia in 13%, leukopenia in 30%, thrombocytopenis in 10%, positive stool occult blood in 27%, proteinuria in 33% and hypoalbuminemia in 20%. Increased alkaline phosphatase was 20%, increased was 73%, increased SGPT was 80% and positive SGOT widal test above 1: 160 titer was 43%. With blood culture 73% was isolated, 20% with stool culture, 0% with urine culture, 77% with bone marrow culture and 20% isolated with bone marinrow culture only. Mean duration of defervescence was 4.1 days in chloramphenicol-treated group and 5.5 days in thiamphenicol-treated group. Neutropenia after drug therapy was occurred 62% in CP-treated group and 67% in TP-treated group. Complications occurred in 5 cases of typhoid fever: Intestinal hemorrhage in 2 cases and intestinal perforation, pleurisy, 1st degree AU block in 1 case respectively.

      • KCI등재후보

        미만성 조직구성 림프종의 임상적고찰

        남상숭,천종욱,조진환,김종서,강영우,송홍석 啓明大學校 醫科大學 1987 계명의대학술지 Vol.6 No.1

        A retrospective review is presented for 70 previously untreated adult patients with diffuse histiocytic lymphoma between March 1980 through March 1986 at the Keimyung University. The mean age was 51.4 years with a male to female ratio of 1.7:1. On admission, neck mass was the most frequent symptom in 31 cases(44%) and abdominal pain, fever, weight loss, dysphagia, anorexia, sore throat and abdominal distension were commonly presented. Physical findings revealed peripheral lymph node enlargement in 47 cases (67%) with cervical, inguinal, axillary in order of frequency. Abdominal mass was observed in 12 cases, hepatomegaly 12 cases and intussusception 2 cases and SVC syndrome, exophthalmos, scrotal mass in 1 case respetively. Extra-nodal involvement was 49 cases (70%) and GIT was most frequent site of involvement (15 cases). Laboratory findings revealed anemia in 33%, leukocytosis in 30%, leukopenia in 16%, thrombocytopenia in 7%, hypoproteinemia in 17%, increased alkaline phosphatase in 9% and increased SGOT in 20%. Local-regional involvement (stage Ⅰ-Ⅱ) occurred in 49% and advanced stage (stage Ⅲ-Ⅳ) in 51% and constitutional symptoms were associated with stage Ⅰ-Ⅱ in 15% stage Ⅲ-Ⅳ in 44%. Treatment was performed with radiotherapy in 12 cases, combination chemotherapy in 23 cases and combined modality therapy in 3 cases. Three year survival rate of complete responder is 92% and 3 year survival rate of local-regional disease was 82% and advanced disease was 33%.

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