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이종흔(J. H. Lee),김중수(J. S. Kim),김제훈(J. H. Kim),장일무(I. M. Chang) 한국생약학회 1980 생약학회지 Vol.11 No.1
Siegesbeckia pubescens, $quot;Hi-cheom$quot;, has long been used for antihypertensive agent as a folkloric drug in Korea. Recently, the Compound B, one of diterpene compounds were isolated and determined its chemical structure. The present study is aimed to evaluated antihypertensive activities of the Compound B against the animal model of high blood rat, Okamodo-SHR. The Okamodo-SHR rats were divided into three groups. One group as a control received propranolol, known β-Blocker and the other two group received the Compound B with dose ranges from 20∼50㎎/㎏/day. The blood pressure of rats were measured by using electro-spygmograph having special attachment of pneumatic pulse transducer. It was noted that the Compound B appoared to possess the antihypertensive activities.
Iridoid Compounds가 RNA 및 Protein 생합성에 미치는 영향
허순옥(S. O. Huh),김제훈(J. H. Kim),장일무(I. M. Chang) 한국생약학회 1985 생약학회지 Vol.16 No.2
To investigate a possible biological activity of iridoid glucosides, six compounds, aucubin, catalpol, gardenoside, geniposide, rehmannioside and swertiamarin, were studied in relation with their potential influences in RNA and protein biosyntheses in murine tumor cell, sarcoma 180, in vitro. Protein biosynthesis was slightly inhibited by aucubin, gardenoside and swertiamarin. Degree of inhibition of RNA biosynthesis by those iridoid appeared to be more sensitive than that of protein biosynthesis. When aucubin was pretreated with β-glucosidase to produce its genin form and the sarcoma 180 cells were exposed to this aucubigenin, the protein and RNA biosyntheses in the cells were profoundly inhibited. The results indicate that a biologically active from of iridoid compounds is the hydrolytic products of glycoside, i.e. genin form. It is also suggested that sarcoma 180 cells used in the experiments appear to lack of β-glucosidase, since the inhibitory actions of iridoid glucosides were so slight that those glucosides were not hydrolysed by the enzyme to their genin forms.