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소아 마이코플라즈마 폐렴 후유증으로 생긴 소기도 질환: 고해상CT소견 및 흉부 촬영 소견과의 상관 관계
김인원,이환종,연경모,Kim, In-Won,Lee, Hwan-Jong,Yeon, Gyeong-Mo 대한영상의학회 2003 대한영상의학회지 Vol.48 No.4
목적: 마이코플라즈마 폐렴을 앓고 난 환자에서 나타나는 소기도 질환의 고해상CT 소견을 알아보고, 고해상CT 소견과 폐렴 급성기 및 추적 관찰기의 흉부 촬영 소견과의 상관 관계를 알아보고자 하였다. 대상과 방법: 마이코플라즈마 폐렴을 앓고 난 후에 임상적으로 소기도 질환이 진단된 18명의 환자에서 고해상CT와 흉부 촬영 소견을 후향적으로 분석하였다 (남: 여=8:10, 평균 연령 8.3세, 폐렴 급성기에서 CT까지 평균 기간; 26 개월). 고해상 CT에서 폐실질과 기관지의 이상 소견을 살펴보았고 호기시 시행한 고해상CT(n=13)에서 공기포획이 있는지를 알아보았다. 흉부 촬영은 마이코플라즈마 폐렴의 급성기 (n=15)와 CT를 시행한 시점의 추적 관찰기(n =18)로 나누어 분석하였고, 이러한 흉부 촬영 소견과 고해상 CT 소견의 상관관계를 알아보았다. 결과: 고해상 CT에서 폐실질 내 이상 소견은 13명(72%)에서 발견되었다. 모자이크 형태의 저감쇄도의 폐음영이 10명 (56%)에서 보였고, 호기시 스캔을 시행한 13명중 9명(69%)에서 공기포획이 나타났다. 추적 흉부 촬영 소견에서 정상 소견을 보였던 14명중 9명(64%)에서 고해상CT에서 이러한 폐실질 이상 소견을 볼 수 있었다. 4명(27%)의 환자에서 폐렴 초기 흉부 촬영상 정상 소견으로 보인 부위에서 고해상CT영상에서는 이상 소견을 발견할 수 있었다. 기관지 확장증과 무기폐는 각각 8명(44%)과 4명 (22%)에서 보였다. Swyer-James 증후군을 시사하는 CT소견, 즉 폐용적 감소와 혈관 감쇄를 동반한 일측성 과투과성 폐가 2명(11%)에서 관찰되었다. 결론: 고해상 CT는 소아 마이코플라즈마 폐렴의 후유증으로 발생한 소기도 질환에서 폐실질과 기관지의 이상을 찾는데 유용하다. Purpose: To assess the high-resolution CT (HRCT) findings of small airway abnormalities after mycoplasma pneumonia and correlate them with the findings of chest radiography performed during the acute and follow-up phases of the condition. Materials and Methods: We retrospectively evaluated HRCT and chest radiographic findings of 18 patients with clinical diagnosis of small airway disease after mycoplasma pneumonia (M:F=8:10, mean age: 8.3 years, mean time interval after the initial infection; 26 months). We evaluated the lung parenchymal and bronchial abnormalities on HRCT (n=18). In addition, presence of air-trapping was assessed on expiratory scans (n=13). The findings of HRCT were correlated with those of chest radiography performed during the acute phase of initial infection (n=15) and at the time of CT examination (n=18), respectively. Results: HRCT revealed lung parenchymal abnormalities in 13 patients (72%). A mosaic pattern of lung attenuation was noted in ten patients (10/18, 56%), and air-trapping on expiratory scans was observed in nine (9/13, 69%). In nine of 14 (64%) with negative findings at follow-up chest radiography, one or both of the above parenchymal abnormalities was observed at HRCT. In four patients (27%), parenchymal abnormalities were seen at HRCT in areas considered normal at acute-phase chest radiography. Bronchiectasis or ateclectasis was observed in eight (44%) and four (22%) patients, respectively, at HRCT. The CT features of Swyer-James syndrome such as a unilateral hyperlucent lung with reduced lung volume and attenuated vessels were noted in two patients (11%). Conclusion: HRCT can clearly demonstrate lung parenchymal and bronchial abnormalities of small airway disease after mycoplasma pneumonia in children.
김인원,Kim, In-Won 한국건강관리협회 2003 한국건강관리협회지 Vol.1 No.1
Vomiting in pediatric patient is frequently encountered problem in emergency room or outpatient clinic. In differential diagnosis, age of the patient or accompanying symptoms should be considered in the differential diagnosis. Accurate diagnosis is very important because surgical treatment is necessary in some of the conditions. Imaging diagnosis of conservative modality such as upper gastrointestinal series or colon study is still important radiological examination in the initial differential diagnosis, but recently ultrasonography offers accurate diagnosis in many situations. The cause of vomiting in pediatric are diverse according to the age group :neonatal sepsis, necrotizing enterocolitis, or hypertrophic pyloric stenosis in neonates : gastroesophageal reflux, viral enteritis, or intussusception in infant: midgut volvulus, appendicitis, metabolic disorders, or increased intracranial pressure also an be the cause. knowledge of radiological findings of normal gastrointestinal tract is important to recognize abnormalities. A discussion of radiological findings in variable surgical conditions to present as vomiting in pediatric patients is offered.
김인원,Kim, In-Won 한국도서관협회 1971 圖協月報 Vol.12 No.7
이 글은 불란서 파리에 있는 국제교육계획연구소가 매년 주관하는 교육계획가 훈련과정에 포함된 도서관계획 세미나에서 토의된 내용과 계획업무 및 수행방법 등을 검토한 글을 번역한 것이다. 역자 주
통현이팔단 에탄올 추출물의 Methicillin Resistant Staphylococcus aureus에 대한 항균활성
김인원 ( In Won Kim ),강옥화 ( Ok Hwa Kang ),공룡 ( Ryong Kong ),권동렬 ( Dong Yeul Kwon ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.5
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a human pathogen. New antibacterial agents are needed to treat MRSA-related infections. This study investigated the antibacterial activity of EtOH 70% extracts of Tonghyeonipal-dan (THD) which prescription is composed of oriental medicine against MRSA. Methods: The antibacterial activity of THD was evaluated against MRSA strains by using the Disc diffusion method, broth microdilution method, Checkerboard dilution test, and Time-kill test; its mechanism of action was investigated by bacteriolysis, detergent or ATPase inhibitors were used. Results: The minimum inhibitory concentration (MIC) of THD is 1,000~2,000 μg/mL against MRSA. In the checkerboard dilution test, fractional inhibitory concentration index (FICI) of THD in combination with antibiotics indicated synergy or partial synergism against S. aureus. Furthermore, a time-kill assay showed that the growth of the tasted bacteria was considerably inhibited after 24 h of treatment with the combination of THD with selected antibiotics. For measurement of cell membrane permeability, THD 500 μg/mL along with concentration of Triton X-100 (TX) and Tris-(hydroxymethyl) aminomethane (TRIS) were used. In the other hand, N,N-dicyclohexylcarbodimide (DCCD) and Sodium azide (NaN3) were used as an inhibitor of ATPase. TX, TRIS, DCCD and NaN3 cooperation against S. aureus showed synergistic action. Conclusions: Accordingly, antimicrobial activity of THD was affected by cell membrane and inhibitor of ATPase were assessed. These results suggest that THD has antibacterial activity, and that THD extract offers great potential as a natural antibiotic against MRSA.