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난소의 난황낭종양을 가진 환자에서 bleomycin, etoposide 및 cisplatin의 병합 항암화학요법 후 결과 분석
김지영 ( Ji Young Kim ),신유정 ( Yu Jung Shin ),문제원 ( Jei Won Moon ),박정열 ( Jeong Yeol Park ),김대연 ( Dae Yeon Kim ),이주학 ( Joo Hak Lee ),김종혁 ( Jong Hyeok Kim ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),남주현 ( 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.11
Objective: The aim of this study was to evaluate the oncologic and reproductive outcomes of patients with ovarian yolk sac tumor after bleomycin, etoposide, cisplatin (BEP) chemotherapy following surgery. Methods: Of 145 patients with histologically confirmed malignant ovarian germ cell tumor, 43 had yolk sac tumor and received BEP chemotherapy after surgery. A retrospective analysis of these patients was performed. Results: The mean age of 43 patients was 24.8 years (range, 7 to 59 years). Thirty eight patients were nulliparous. Of 179 BEP chemotherapy cycles, grade 1~2 hematologic and non-hematologic adverse events occurred in 46 cycles in 21 patients. Thirty nine patients showed complete remission, 1 patient showed partial remission, and 3 patient had progressive disease during BEP chemotherapy. After median follow-up time of 57 months (range, 3 to 153 months), 5 patients had recurrent disease and three of them died of disease. The 5-year recurrence free survival rate and overall survival rate were 86% and 94%, respectively. After chemotherapy, all but one premenarchal patients had normal menstruation. Of them 5 patients tried to conceive and 3 of them succeeded in pregnancy. Conclusion: BEP chemotherapy was very safe and effective in patients with ovarian yolk sac tumor. Survival outcomes are excellent and reproductive outcomes are promising after BEP chemotherapy.
부인암 환자 말초 혈액의 CD4(+)CD25(+)조절 T림프구 분포
마진영 ( Jin Young Ma ),김용만 ( Yong Man Kim ),정민형 ( Min Hyung Jung ),송하영 ( Ha Young Song ),김대연 ( Dae Yeon Kim ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ),목정은 ( Jung Eun Mok ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.3
Objective: Recently the existence of a CD4(+)CD25(+) regulatory (Treg) population has been described in rodents and humans. It is unclear how the immune response cells interact to tumor cells effectively, but the malignant tumor cell growth was suppressed by the main effect of T lymphocytes and natural killer cells in experimental studies using various biologic response modifier. This study was performed to investigate the proportion of CD4+CD25(high) Tregs and expression of Foxp3 in Peripheral blood (PBL)s in patients with cervical, ovarian or uterine cancers. Methods: Blood samples were collected from 10 healthy women and a total of 40 patients with gynecologic cancer at department of Obstetrics and Gynecology, Asan Medical Center, Seoul, Korea, from March 2005 to September 2005, were enrolled in study group. Information regarding patient history and tumor stage was recorded. They were diagnosed at same center at first, and never been treated any therapy. The population of CD4(+)CD25(+high) Tregs as a percentage of total CD4+cells was evaluated by flow cytometric analysis. We measured the proportion of Treg cell that co-express CD4 and CD25 in the peripheral blood lymphocytes form patients with either cervical, ovarian uterine cancer or carcinoma in situ of cervix. Expression of Foxp3 in the CD4+subsets defined by electrophoresis. Results: The following tumor entities were included cervical cancer (n=10. 7 in stage Ⅰ, 1 in stage II, 1 in stage III, 1 in stage Ⅳ); ovarian cancer (n=10. 4 in stage Ⅰ, 0 in stage II, 5 in stage III, 1 in stage Ⅳ), ; uterine cancer (n=10. 9 in stage Ⅰ, 0 in stage II, 0 in stage III, 1 in stage Ⅳ). In cervical cancer patient, ovarian cancer patients, uterine cancer patients and healthy women, the proportion of CD4+CD25(high) Tregs was 4.53% (SD 2.30), 6.89% (SD 7.81), 4.37% (SD 2.43) and 0.87% (SD 0.57) of the total CD4+cells respectively. The proportion of CD4+CD25(+high) T cells was significantly higher in cervical cancer patients (p=0.016), ovarian cancer patients (p=0.001) and uterine cancer patients (p=0.038) when compared with healthy women. But there was no significant difference in proportion of CD4+CD25+ Tregs comparing with healthy women. Expression of Foxp3 was significantly thicker in tumor-associated lymphocytes than control T cells by electrophoresis. Conclusion: In conclusion, our data suggested that the increase in frequency of regulatory T cells might play a role in modulation of the immune response against cervical, ovarian, uterine cancer could be important in design of immunotherapeutic approaches.
종방향 활동체결구를 이용한 영종대교 남측 접속교량의 장대레일화 사례
이덕영(Lee Duck Young),양신추(Yang Shin Chu),권순섭(Kwon Soon Sub),김용만(Kim Yong Man) 한국철도학회 2004 한국철도학회 학술발표대회논문집 Vol.- No.-
For New In-Cheon Airport. South Approach Section of Young Jong Great Bridge is to be special concerned to CWR due to substructure was already constructed former railroad bridge design specification. So we applied maintenance free system and CWR (Continuous Welded Rail) by ZLR(Zero Longitudinal Restraint) at bridge expansion joint part. This thesis generally introduce for CWR by ZLR at South Approach Section of Young Jong Great Bridge.
난소의 악성 배세포종양에서 림프절 절제술의 필요성 및 보존적 수술 후 난소기능 및 가임력 유지에 대한 연구
김대연 ( Dae Yeon Kim ),남주현 ( Joo Hyun Nam ),유항조 ( Hang Jo Yoo ),김미경 ( Mi Kyung Kim ),김종혁 ( Jong Hyeok Kim ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),목정은 ( Jung Eun Mok ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
Objective: To evaluate the long-term fertility and reproductive outcomes after conservative surgery, to observe the recurrence pattern and to elucidate the significance of retroperitoneal lymph node evaluation in patients with malignant ovarian germ cell
최은녕(Eun Nyung Choi),김용만(Yong Man Kim),차지만(Ji Man Cha),유항조(Hang Jo Yoo),김대연(Dae Yeon Kim),이상수(Sang Soo Lee),김종혁(Jong Hyeok Kim),목정은(Jung Eun Mok),남주현(Joo Hyun Nam),김영탁(Young Tak Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1
Objective : Actinomycosis is a rare entity, especially in the female genital tract, which presents some difficulties in establishing a correct preoperative diagnosis. Pelvic actinomycosis can mimick pelvic or intra- abdominal malignancy leading to mutilating surgical exercise. The authors surveyed 12 cases of pelvic actinomycosis for advice to detection and treatment of the pelvic actinomycosis. Methods : The authors studied retrospectively 12 cases which have admitted to Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center for pelvic actinomycosis from January. 1, 1991 to December. 31, 2000. Results : 41.7% of the cases occurred in 31-40 years age group, 91.7% of cases associated with intrauterine devices for 5-21 years. Most common complaints were abdominal pain and palpable mass, and other complaints were vaginal discharge, bowel habit change, nausea, vomiting and fever. The actinomycosis lesions involved one or both ovaries in all 12 cases. In 11 cases, the lesions extended to other areas, such as the uterus, parametrium, pelvic walls, cul-de-sac, colon and bladder. All patients underwent surgery that included removal of the lesions with ipsilateral or bilateral adnexa and, in specific cases, with extension of the lesions, hysterectomy, colostomy and primary repair of bladder or rectum. After surgery, 9 patients were treated with penicillin and the duration of treatment was 12 months in 2 patients, 6 months in 3, ≤3 months in 3 and one patient was being treated for 2 months. Other 3 patients were treated with metronidazole, cephalosporin and aminoglycoside during 1-3 weeks. All patients were alive and well. Conclusion : It is needed to make an earlier and more correct diagnosis of actinomycosis, and high-dose intravenous antibiotic therapy can reduce the risk of nearby pelvic structure injuries. In cases of pelvic actinomycosis where the abscess can be completely resectable, a shorter period of antibiotic therapy can be required.
자궁경부 편평상피암에서 in vitro , ex vivo 및 in vivo 수소 핵 자기공명분광상의 특성 분석
김상태 ( Sang Tae Kim ),이동헌 ( Dong Heon Lee ),남주현 ( Joo Hyun Nam ),이정희 ( Jung Hee Lee ),김용만 ( Yong Man Kim ),김종혁 ( Jong Hyeok Kim ),목정은 ( Jung Eun Mok ),김영탁 ( Young Tak Kim ),조경식 ( Kyoung Sik Cho ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
Objective: To evaluate the potential value of in vitro, ex vivo, and localized in vivo 'H Magnetic resonance spectroscopy(MRS) for detecting and characterizing squamous cell carcinoma of uterine cervix. Materials and Methods: Eleven cases of squamous cell carcinoma and 6 cases of normal cervical tissue underwent in vitro and ex vivo 'H MRS. In vitro analysis was carried out after processing the specimen with dual phase extraction method. In ex vivo test, at least 500 p 1 of tissue specimen was directly analyzed by 100.14 MHz NMR spectrometer (Bruker 11.7T AMX, Germany) without any processing procedure. In addition, 29 patients with squamous cell carcinoma of uterine cervix and 6 normal women were examined by in vivo 'H MRS. Localized in vivo 'H MR spectra of the human uterine cervix were obtained using PRESS sequence with homebuilt endovaginal surface coil. Surface coil T2 weighted images were used as the localizer images where voxel (1-3 mm3) was located to contain the cancer area only. The following spectral acquisition parameters were used: SW=2500 Hz, SI=2048, TR=3.0 sec, TE=20/135 msec, NEX=2, and NS=36. HO signal suppressed down to 96-99% by 3-pulse CHESS technique. The spectra were processed with 0.5 Hz of exponential line broadening, zerofilling of 8K followed by linear phasing. Results: The intense resonance signal at 0.9 ppm and 1.3 ppm by lipid component of triglyceride was visible in all cases (11/11) of squamous cell cancer of cervix both in vitro and ex vivo test. But in 6 normal cervical tissues, such peaks were not detected at all. The in vivo spectrum of the cervical cancer was comparable with that in in vitro and ex vivo spectrum. In the in vivo spectra of the cervical cancer, the resonance peaks at 0.9 ppm, 1.3 ppm, 3.0 ppm, and 3.2 ppm from CH3 and CH2 groups of neutral mobile lipid (triglyceride), creatine, and choline containing residues respectively, were consistent with results reported earlier. The resonance peak at 1.3 ppm which is from acyl chains of triglyceride was characteristically intense and seen in 25 of 29 cancer patients. But triglyceride peak at 1.3 ppm was not detected in normal cervix (sensitivity 86.2%; specificity 100%; positive predictive value 100%; negative predictive value 60%). Conclusion: The study shows that H MRS can effectively discriminate squamous cell cancer from normal cervix in most cases. It also demonstrates the feasibility of localized in vivo 'H MRS technique as a new diagnostic modality in the detection of squamous carcinoma of uterine cervix.