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- 저자 : 김성환 ( Sh Kim ) (검색결과 3 건)
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폐경 후 여성에서 경피적 에스트로겐 보충요법시 병행 투여된 활성형 비타민 D의 골밀도 및 골대사에 미치는 영향에 관한 연구
김성환(SW Kim),박은동(ED Park),김도형(DH Kim),김흥열(HY Kim),석원일(WI Suk),서남원(NW Seo),이상민(SM Lee),노선화(SH Noh) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.4
To evaluate the impacts of vitamin-D on the bone mineral density and bone metabolism in the estrogen replacement 1-year trials of 3 grops: Group 1 was 35 wemen recieved the treatment with 0.5 ㎍ of vitamin D daily by oral administration, Group Ⅱ was 50 wemen recieved the treatment with 50 ㎍ of 17 β-estradiol by percutaneous administration, Group Ⅲ was 35 wemen recieved with percutaneous estrogen with daily addition of vitamin D. In all subjects, bone mineral density (BMD) of lumbar spine and femur neck, urinary calcium/creatinine ratio, and serum osteocalcin were measured before treatment and after 6 and 12 months of treatment. BMD of femur neck in Group I, Group Ⅱ and Group Ⅲ increased but not significantly compared to basal level at 6 months and/or 12 months of treatment. As for BMD of lumbar spine, it increased significantly during the treatment in Group Ⅱ and Group Ⅲ, but not in Group Ⅰ. Serum osteocalcin in Group Ⅱ and Group Ⅲ decreased significanly at 12 months of treatment compared with Group Ⅰ. Urinary calcium/creatinine ratio in Group Ⅱ, Group Ⅲ, decreased significantly at 12 months of treatment compared with Group I. From the above results, it might be suggested that combined therapy (percutaneous estrogen with daily addition of vitamin D) is more effective in post menopausal women with the protection on decreasing bone mineral density.
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이상호 ( Sh Lee ),김성환 ( Sh Kim ),김봉룡 ( Br Kim ),김현정 ( Hj Kim ),( S. Bhandari ),정인섭 ( Is Jung ),홍수진 ( Sj Hong ),유창범 ( Cb Ryu ),김진오 ( Jo Kim ),조주영 ( Jy Cho ),이준성 ( Js Lee ),이문성 ( Ms Lee ),심찬섭 ( Cs Shim ),김 대한장연구학회 2003 Intestinal Research Vol.1 No.1
Granular cell tumors (GCT) are rare tumors of neural origin involving mostly the tongue and skin. However, with the increased use of endoscopy, the gastrointestinal tract has been reported as a common location. the esophagus is the gastrointestinal site most frequently affected. Such tumors are rarely seen in the stomach, colon or rectum. It usually appears as a small, poorly circumscribed nodule with benign clinical course. Subsequently one case of a granular cell tumor of the ascending colon in 38 year-old female which were successfully diagnosed by a endoscopy and a endosonography and confirmed using snare polypectomy is here in reported. (Intestinal Research 2003;1:59-63)
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항암제 Cis - platinum 의 독성에 관한 연구
신승주(SJ Shin),김성환(SW Kim),조수현(SH Cho),배동한(DH Bae),강길전(KC kang),김두상(DS Kim) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.2
결 론 1981년 12월부터 1982년 8월까지 한양대학병원 산부인과학 교실에서 D.D.P.를 사용하여 최소 3회 이상의 화학 치료를 받았던 자궁경부암 환자 12예를 대상으로 그 독성을 조사분석하였던 바. 다음과 같은 결론을 얻었다. 1. 청신경독성은 조사한 8예중 3예(37.5%)에서 나타났으며 전 예에서 양측성이었고 그 중 2예는 고음, 나머지 1예는 저음청각장애이었다. 2. 빈혈은 총 12예중 4예(33.3%)에서 나타났으며 대부분 ndrmochromic eormocytic anemia였으며 수혈로 교정이 가능하였다. 3. 골수에 대한 독성은 총 치료 50회중 백혈구 감소증은 23회(46%), 혈소판 감소증은 6회(12%)로 나타났으며 이는 가역적이었고 심한 중증의 예나 패혈증등은 나타나지 않았다. 4. 신장독성은 BUN의 증가가 12예중 4예(33.3%)에서 나타났고 혈청 creatininel의 증가가 12예중 2예(16.6%),BUN과 creatinined의 동시 증가가 12예중 4예(S3.3%)로 나타나 총 12예중 10예(83.3%)에서 나타났고 모두 경중이었다. 또한 신장독성은 투여 용량에 비례 하였고 가역적이었다. 5. 위장관계에 대한 독성은 주로 오심 및 구토증이었는데 이는 전 예에서 나타났으며 가장 환자에게 고통을 주는 요인이었으며 perrphenazinedp 의한 항오심 효과는 다른 약물에 비하여 비교적 강한 경향을 보였다. The toxicity of cis-platinum was evaluated in 12 patients who were treated for advanced or recurrent squamous cell carcinoma of the cervix with the dosage schedule of 2Omg/m of 5 days every 3 weeks at the Department of 0bstet. and Gynecol., Hanyang University Hospital from Dec.1981 through Aug.1982. The results were as follows: 1. The most frequent and troublesome side effects were gastrointestinal symptoms of nausea and vomitings that occurred in all cases. These side effects were more tolerable in the patients treated with perphenazine than those with chloropromazine. 2. Nephrotoxicity was noted in 33.3%(4/12) of patients as determined by an elevation of BUN, in 16.6%(2/12) by an elevation of serum creatinine and in 33.3%(4/12) by an elevation of serum creatinine and BUN. The toxicities were all in mild degree, dose related and reversible. 3. For the hematologic toxicity, leukopenia occurred in 58.3%(7/12) of the patients, thromcytopenia in 41.7% (5/12), and anemia in 33.3% (4/12).They were reversibie and not life threatening· 4. Ototoxicity occurred in 37.5%(3/8) of patients with bilateral involvements in all cases.
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