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광열치료의 열 투여량에 따른 세포 자멸사에 대한 수치적 연구
김무중(Moojoong Kim),김관택(Gwantaek Kim),김동혁(Donghyuk Kim),이희진(Heejin Kim),유재석(Jaisuk Yoo),김동권(Dong-Kwon Kim),김현정(Hyun Jung Kim) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12
Photothermal therapy(PTT) is a therapy for selective ablation of the tumor by using a photothermal effect. However, in spite of using the photothermal effect, which is one of the fields of heat transfer, the research on heat transfer for photothermal therapy is insufficient. In photothermal therapy, GNPs (gold nanoparticles) are used as a photothermal enhancer to selective ablation of tumor. At this time, since the photothermal effect are different depending on the characteristics of the GNPs, and thermal and optical conditions of NIR laser, it is important to find an optimal condition suitable for selective ablation for effective photothermal therapy. In previous photothermal therapy studies, the temperature distribution in tumor tissues has been studied qualitatively. However, the correlation between the death of tumor tissue and thermal and optical conditions of NIR laser has not been quantitatively studied in terms of heat transfer. Therefore, in this study, the conditions (e.g. intensity, beam radius) of the lasers satisfying the apoptosis temperature (43℃ ~ 50℃ , which can effectively ablate tumors) were obtained for various sizes of tumor (width: 2mm ~ 10mm, depth: 0.5mm ~ 4.5mm) using numerical analysis. And quantitative analysis of the apoptosis rate of tumor tissue according to the thermal and optical conditions of photothermal therapy was performed.
김동혁(Donghyuk Kim),이정환(Junghwan Lee),윤성의(Sung-Eui Yoon) 한국HCI학회 2013 한국HCI학회 학술대회 Vol.2013 No.1
모션 플래닝 분야에서 실시간으로 주변을 감지하고 움직이는 로봇의 경우 변화하는 장애물들에 대한 동적인 감지 및 분석과 제한된 경로 계산 시간 등의 제약이 따른다. 특히 무인 자동차와 같이 제어의 제약을 고려한 충돌이 없는 유효 경로 생성은 그 자체 만으로도 중요한 이슈이다. 본 연구에서는 샘플링 기반의 알고리즘인 RRT<SUP>*</SUP> 를 이용한 무인 자동차의 경로 생성기법에 대한 연구와 실시간 경로 생성을 위해 고려되는 부가적인 요소들의 유기적인 결합에 대해 소개한다. In motion planning field, it is necessary for the mobile robots which have ability to recognize the surrounding environments and move by itself, to detect, analyze the obstacles and compute feasible trajectory in real time. Especially, in case of car-like robots which have control constraints, it is challenging to only generate a feasible trajectory in a limited time. In this paper, we extend sampling based algorithm RRT<SUP>*</SUP> for autonomous vehicle with control constraints to takes advantage of dubins path, and its simplicity for easing trajectory calculation. In addition, we show some simple collision detection technique from dubins path.
다양한 가열조건에 따른 광열 효과를 이용한 편평세포암 사멸에 관한 수치적 연구
김동혁(Donghyuk Kim),김현정(Hyunjung Kim) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Recently, photothermal therapy has attracted attention as an alternative treatment to conventional surgical techniques because it does not bleed out, and patients quickly recover after treatment compared to incisional surgery. Photothermal therapy is a treatment technique that induces tumor death by increasing the temperature using the photothermal effect, which converts light energy into thermal energy. This study conducted a numerical analysis based on heat transfer to induce apoptosis temperature of tumor tissue for various heating conditions in photothermal therapy. Numerical analysis using the Monte Carlo method was performed on multi-layered skin structure containing squamous cell carcinoma. Through the effective apoptosis retention ratio, numerical analysis results show the quantitative correlation for various variables. This study showed an optimal condition for maximizing apoptosis within tumor tissue while minimizing thermal damage to surrounding tissues under various heating conditions.
김동혁(Kim, Donghyuk) 역사학회 2017 역사학보 Vol.0 No.236
Yevsei Liberman posed a reformist agenda to improve the material incentive system and increase the profitability of enterprises, as a person at the center of the controversy related to the reform or improvement of the system of Soviet and Eastern Socialism during the Cold War. This was a question of how to provide incentives to increase the profitability of individual and whole enterprises. His argument is also directly related to the debate on the essential nature of the socialist economy in that it discusses how to provide specific economic incentives to increase the profitability of an individual enterprise in a socialist society not intended for private profit. Existing studies range from the introduction of capitalist factors to the argument that Liberman’s argument elaborates the pricing mechanism under the planned economy. However, this is based on the dichotomical idea of the introduction of market elements or the elaboration of the central plan for the Soviet economic system. A review of the progress of the Liberman debate and its acceptance into policy reveals that it can not be judged whether or not the economic debate and the reform program of 1965 coincide with Liberman’s argument. The controversy between the material incentive system and the profitability of companies since 1955 has been converged with orthodox theories such as Gatovsky and reformist theories such as Liberman and Nemchinov. In other words, the debate over Liberman’s claims at the time was an attempt to solve problems within the Soviet socialist economic system.