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심근경색에서 측부순환 유무에 따른 99mTc-MIBI 심근 SPECT 소견
김덕윤(Deog Yoon Kim),양형인(Hyung In Yang),강홍선(Heung Sun Kang),조정휘(Chung Whee Choue),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),송정상(Jung Sang Song),배종화(Jong Hoa Bae),김재만(Jae Man Kim),나득영(Deug Young Na),박은경(Eun 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
N/A The coronary collateral vessels have revealed their significance in terms of reduction of infarct size, preservation left ventricular function, and prevention of left ventricular aneurysm in patients with myocardial infarction. The purpose of this study were to evaluated the relation between collateral circulation and 99mTc-MIBI Heart SPECT in patient with acute myocardial infarction and their clinical significance. The fifty six MI patients with antegrade TIMI perfusion grade 0 and 1 were studied. The pat#ients #were classified into two groups; Group I inclueded 30 patients with grade 2, 3 Collateral flow. Group II inclueded 26 patients with grade 0, 1 Collateral flow. Collateral filling were graded from 0 to 3; 0- none, 1- Filling of side branch only, 2- Partial filling of the epicardial segment, 3- Complete filling of epicardial segment. Clinical variables, left ventricular function, 99mTc-MIBI Heart SPECT were analyzed with angiographic finding. Results were following: 1) Collateral visualization was found to be greater in patient with invoivement of right coronary artery (RCA). The callateral development site of infarct related artery was RCA 15 cases, left anterior descending artery (LAD) 10 cases, left circumflex artery (LCX) 5 cases, and the collateral circulation from LAD to RCA was 13 cases (40.6%). 2) There was a tendency to be decreased in peak CK activity with group I . 3) The presence of good collateral channels was more frequently 99mTc-MIBI reversible perfusion defect (83.4% vs 15.3%, p<0.05). 4) No differences af left ventrieular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), ejection fraction (EF) were noted between group I and group II. The presence of good collateral channels did affect the frequency of occurrence of 99mTc-MlBI reversible perfusion defect.
99mTc - LDL ( Low Density Lipoprotein ) 신티그라피를 이용한 동맥경화병소 진단
김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi),고은미(Eun Mi Koh),김덕윤(Deog Yoon Kim),김성운(Sung Woon Kim),양인명(In Myung Yang),우정택(Jeong Taek Woo) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2
N/A Diagnostic approaches such as angiography, ultrasound, computed tomography and nuclear magnetic resonance have limitation for contributing to the early clinical diagnosis of atherosclerosis. Recently, Tc-99m-labelled low density lipoprotein was developed to detect early atherosclerotic lesion by external imaging with gamma camera. To determine whether Tc-99m- LDL scintigraphy can visualize the active atherosclerotic lesion, rabbits were injected with Tc- 99m-LDL, 3 months after feeding dietary fat (lanolin) and we obtained following results. 1) Labelling efficiency of Tc-99m-LDL was 79∼88%. 2) Biodistribution study of normal rabbits with Tc-99m-LDL revealed the high activities in spleen, adrenal gland, liver, kidney which are major organs of high metabolic rate of LDL. 3) Three months after feeding lanolin, serum cholesterol was markedly increased from 74±17 mg/dl to 979±153 mg/dl and histologic study of aorta after sacrificing the rabbit demonstrated marked atherosclerotic changes. 4) Atherosclerotic lesion of abdominal aorta which was confirmed with histologic study could be demonstrated in Tc-99m-LDL scintigraphy after feeding lanolin for 3 months. In conclusion, the results of this preliminary investigation suggest that it may be possible to image active atheromatous lesion with Tc-99m-LDL. It is anticipated that this promising agent may allow the in vive monitoring of preclinical atherosclerotic lesions and may be useful to evaluate the metabolic path way of LDL in humans.
말초성 동맥 질환에 있어서 201TI을 이용한 말초혈관 관류스캔의 유용성
김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi),고은미(Eun Mi Koh),김덕윤(Deog Yoon Kim),우인숙(In Sook Woo),나정일(Jung Il Nah) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.2
N/A Peripheral arterial disease, because of its significant and prolonged morbidity and related mortality is a major medical and surgical problem. Contrast angiograrn remains the essential standard for the anatomic demonstration of disease. It does not, however, provide data suitable for quantification or any evaluation of the microcirculation. For these reasons, radionuclide studies are playing an increasingly important role by not only confirming the diagnosis and offering objective data on the physiologic significance of anatomic lesions, but by offering prognosis of healing and prediction of therapeutic results. In addition, radionuclide procedures offer means t.o safely and repeatedly monitor response to therapy and long term follow up. 1'he object of this study was to evaluate the clinical availability of 'Tl perfusion scan in patients with peripheral arteriai diseases. We performed 'Tl perfusion scans in patients with five Buerger s disease (10 legs), six DM gangrenes (12 legs) and classified three perfusion pattern groups. Finally we compared treatment modalities among each groups and compaired Tl-201 perfusion scan findings with angiographic findings in six patients with Buergers disease. The results were as follows: 1) Seven legs showed increased perfusion in stress image and normal or increased perfusion in resting image (type 1). Six legs showed decreased perfusion in stress image and irnproved in resting image (type II). Of total 13 legs, only 1 leg needed to amputation. 2) Three legs showed decreased perfusion in stress and resting irnage (type III), and subsequently all cases were received surgical amputation. 3) In six Buergers disease patients, there were disagreernents in two patients (2 legs) between 'Tl scan and angiography, in which angiograms were normal but 'Tl scans shawed type II perfusion patterns.
정상 관동맥 조영상을 갖는 급성 심근경색증 환자의 임상적 특징 및 99mTc - MIBI 심근 SPECT 소견
김광원(Kwang Won Kim),김덕윤(Deog Yoon Kim),박명재(Myung Jae Park),최태열(Tae Youl Choi),강홍선(Heung Sun Kang),조정휘(Chung Whee Choue),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),송정상(Jung Sang Song),배종화(Jong Hoa Bae) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1
N/A Among 64 patients with acute myocardial infarction who underwent coronary angiogrphy, 7 patients (10.9%)showed normal coronary artery. Six patients were men and 1 patient was female. The mean age of patients were 31.1±3.9 years. Among the risk factors of coronary heart disease, smoking was most probable factor in patients with acute myocardial infarction with normal coronary angiography. Tc-99m-MIBI heart SPECT performed 5 of 7 patients and showed that it could be used in diagnosis, localization, extent of infarct area in patients with acute myocardial infarction with normal coronary angiography. But follow up Tc-99m-MIBI heart SPECT study will be needed to define the ability of myocardial viability in this patients.
김광원(Kwang Won Kim),최영길(Young Kil Choi),고은미(Eun Mi Koh),김덕윤(Deog Yoon Kim),김병호(Byung Ho Kim),장영운(Young Woon Chang),장린(Rin Chang),김용봉(Yong Bong Kim) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A Scintigraphic measurement of gastric emptying time has been reported to be influenced by the variation in depth of radionuclide within the stomach. In order to determine the effect of tissue attenuation in the measurement of gastric emptying time, 15 gastric emptying studies were performed with Tc-99m labeled egg sandwiches. Single anterior detector method overestimated the T1/2 by an average of 13% than geometric mean method and the range of overestimation was wide (from -13% to +32%). Therefore, to evaluate the gastric empthying time accurately, methods of attenuation correction are needed.
당뇨병 환자에서의 PCR를 이용한 apolipoprotein E 유전자형 분석
팽정령 ( Jung Ryung Paeng ),김덕윤 ( Deog Yoon Kim ),우정택 ( Jung Taek Woo ),김성운 ( Sung Woon Kim ),양인명 ( In Myung Yang ),김진우 ( Jin Woo Kim ),김영설 ( Young Seol Kim ),김광원 ( Kwang Won Kim ),최영길 ( Yong Kil Choi ) 대한임상검사과학회 1992 대한임상검사과학회지(KJCLS) Vol.24 No.1
당뇨병은 고지혈증이 흔히 동반되며 다양한 벼인이 관여된다. Apolipoprotein E(단백질의 변이는) 고지혈증 유발성과 apo E isoform 의 분석이 시행되고있다. 최근 apo E 유전자형을 밝히는데 polymerase chain reaction(PCR) 방볍이 이용되고 있다. Apo E 는 299개의 아미노상으로 되어 있고 3개의 isoform 을 갖고 있는데 112번 158번째 아미노산서열의 차이점에 따라 E2, E3, E4로 구분한다. 본 연구에서는 apo E gene 을 PCR 법으로 증폭시켜 Hha I 제한효소로 소화시킨 다음 polyacryl-amide gel electrophoresis 하여 간편하고 신속하게 유전자형을 결정하였다. Hha I 은 Arginine 을 encod-ing 하는 GCGC sote를 인식 절단하는 효소이며 112arg(E4)과 158 arg(E3, E4)는 전단하지만 112cys(E2, E3) 와 15CYS(E2)는 GTGC 로 절단하지 못한다. 이러한 제한효소의 특성을 이용하여 Hha I restriciction fragment length 를 조사하였다. 당뇨병 환자 79명에서 각가의 유전자형을 분류한 결과 E2(6.3%), E3(81.0%), E4(12.7%)로 나타났으며 정신인 73명에서의 유전자형은 E2(4.8%), E3(84.9%), E4(10.3%)로 나타났다. 이상의 결과에서 보면 당뇨병 환자와 대조군과의 유전자 빈도에서의 통계적 유의성은 없었다. 그러나 유전자 빈도에 있어서는 우리 결과와 일본의 결과는 매우 유사하지만 유럽 지역의 결과와는 차이를 보였다. 이러한 결과의 차이는 인종간의 차이 및 유전자형을 결정한는 PCR법과 단백질을 분석하는 isoelectric focusing 간의 차이로 생각되며 향후 PCR법 이 유전자형을 결정하고 진단하는데 중요한 분야기 될 것으로 사료된다.