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노형운(Hyung-Woon Roh),서상호(Sang-Ho Suh),박준길(JoonGil Park),이병권(Byung-Kwon Lee),권혁문(Hyuck-Moon Kwon) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
From the previous study, it found that hemodynamics were correlated with stenosis in coronary artery. The flow characteristics and distributions of the hemodynamic wall parameters in the coronary artery are investigated under physiological flow condition. The present study is also aimed to establish the mechanism of the generation of atherosclerosis by analyzing the hemodynamic variables in the coronary artery where atherosclerosis frequently occured. The stenosis phenomena due to atherosclerosis are related to not only biochemical reaction between blood and blood vessel but also the hemodynamic factors like flow separation and oscillatory wall shear stress.
생체내 혈관조형술을 이용한 관상동맥의 차원 형상화 및 혈류특성 해석
노형운(Hyung-Woon Roh),서상호(Sang-Ho Suh),권혁문(Hyuck-Moon Kwon),이병권(Byung-Kwon Lee) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.11
The purpose of the present study was to establish the mechanism of the generation of<br/> atherosclerosis by analyzing the hemodynamic variables in the coronary artery where atherosclerosis<br/> occurs frequently. From the previous results, the stenosis phenomena due to atherosclerosis were related<br/> to not only biochemical reaction between blood and blood vessel but also the hemodynamic factors like<br/> flow separation and oscillatory wall shear stress. The present study aimed to investigate the causes of<br/> the generation and progression of atherosclerosis in the coronary artery. This study also aimed to<br/> develop the softwares which generate automatically three dimensional vascular models obtained by the<br/> angiogram images and the computer vision techniques. In the present study, the flow patterns for full<br/> three-dimensional hemodynamic characteristics were analyzed. To understand the three-dimensional<br/> hemodynamic characteristics, the wall shear stress distributions and secondary flows were investigated<br/> quantitatively.
선천성 심장질환에 대한 Fontan 순환의 유체역학적 분석
노형운(Hyung-Woon Roh),서상호(Sang-Ho Suh),이병권(Byung-Kwon Lee),권혁문(Hyukc-Moon Kwon) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
In 1971 Fontan and Baudet reported on a palliative operation in patients with tricuspid atresia. The new idea was to direct venous blood flow into the pulmonary arteries without a pumping chamber in between. While there were many modification developed after initial suggestion and they made a advance for survival benefit. However, the complete pulmonary flow were not restored, and several complications, such as arrhythmia, pulmonary vascular insufficiency, abnormalities in hepatic function, and coagulopathy were still not resolved. We hypothesized that these complications were driven mainly by the deficit of driving force according as right heart bypass. It reported that there were no typical pulmonary blood flow patterns of cardiac origin in patients with Fontan circulation, except for slight late diastolic flow acceleration representing diastolic inflow. The aim of this study is to assess pulmonary blood flow patterns after Fontan surgery by using computational fluid dynamics analysis. It found that the flows from SVC and IVC were not well mixed in all 4 different phases, and IVC flows were not well advanced to pulmonary artery during inspiration. This phenomenon was remarkable especially during inspiration phase in upright position. Conclusively, it might be suggested that Fontan circulation is needed by a pumping structure for mixing blood from SVC and IVC and IVC blood flow advance.
노형운(Hyung-Woon Roh),서상호(Sang-Ho Suh),권혁문(Hyuck-Moon Kwon),이병권(Byung-Kwon Lee) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4
Bypass anastomosis are frequently adopted for surgical treatments. After the bypass grafting, the<br/> bypass artery is often occluded due to restenosis and/or anastomotic neointimal fibrous hyperplasia<br/> phenomena. Optimal coronary bypass anastomosis should be investigated to improve the<br/> patency for the arterial bypass techniques. The objective of this study is to investigate the<br/> influence of bypass with sequential bypass effects in the stenosed coronary artery. Numerical analyses<br/> are focused on the understanding of the flow patterns for different sequential anastomosis techniques.<br/> Blood flow field is treated as two-dimensional incompressible laminar flow. The finite volume method<br/> is adopted for discretization of the governing equations. The Carreau model is employed as the<br/> constitutive equation for blood. To find the optimal sequential bypass anastomotic configurations, the<br/> mass flow rates at the outlet of different models are compared quantitatively.
노형운(Hyung-Woon Roh),김재수(Jae-Soo Kim),서상호(Sang-Ho Suh),권혁문(Hyuk-Moon Kwon) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.5
Catheters are used to measure translesional pressure gradients in the stenosed coronary arteries.<br/> Catheter insertions during coronary angioplasty cause flow obstructions. A narrowed flow cross section<br/> with catheter present effectively introduced a tighter stenosis than the enlarged residual stenoses after<br/> balloon angiplasty. In this study, three dimensional computer simulations are conducted to investigate<br/> the flow blockage effects due to the catheter insertions during the coronary angioplasty. This study is<br/> also extended to investigate the effects of stenotic vessel sizes and shapes, catheter size and<br/> positioning effects on the blood flow characteristics.
중재적 시술후 동맥경화증의 재발생에 관한 혈류역학적 연구
서상호(Sang-Ho Suh),노형운(Hyung-Woon Roh),권혁문(Hyuck-Moon Kwon),이병권(Byoung-Kwon Lee) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
The objectives of this study were to investigate the hemodynamic characteristics in the atherosclerotic-prone coronary artery and to establish the mechanism of regeneration of atherosclerosis after interventional therapy like stent and balloon angioplasties. This study also aimed to develop softwares which generate automatically three dimensional vascular models using the angiogram images and to visualize the blood flows by the computer vision techniques. In this study, the regeneration mechanism of atherosclerosis after surgical treatments was investigated from the results From the investigation it was concluded that the mechanism of the regeneration of atheroscelrosis was related to the hemodynamic characteristics such as flow separation and oscillatory wall shear stress on the vessel wall.
서상호(Sang-Ho Suh),노형운(Hyung-Woon Roh),권혁문(Hyuck-Moon Kwon),이병권(Byoung-Kwon Lee) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
The objectives of this study were to confirm the hemodynamic characteristics in the atherosclerotic-prone coronary artery and to establish the mechanism of progression and regeneration of atherosclerosis. The hypotheses related to the hemodynamic effects were tested by using computer simulation. This study also aimed to develop softwares which generate automatically three dimensional vascular models obtained by the angiogram images and to visualize the blood flows using the computer vision techniques. In this study, the mechanism of the regeneration of atherosclerosis after interventional and surgical treatment was investigated using by the results of our previous study which concerned the mechanism of generation and development and progression of atherosclerosis. From the investigation, it was concluded that the mechanism of the progression and regeneration of atheroscelrosis was related to the hemodynamic characteristics such as flow separation and oscillatory wall shear stress on the vessel wall..