Lipopolysaccharide에 의해 유발된 발열에 있어서 升麻의 해열효과

권일호(Il-Ho Kwon),김남권(Nam-Kwon Kim),강학천(Hsueh-Chuan Chiang),임홍진(Hong-Jin Lim),김진만(Jin-Man Kim) 대한한의학회 2002 대한한의학회지 Vol.23 No.4

무기체계개발에서 시스템 성숙도와 기술적 성능 달성도를 연계한 시스템 성능 측정 방법

권일호(Kwon, Il-Ho),이재천(Lee, Jae-Chon) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.9

최근의 무기체계 연구개발에서 실패의 주요인은 요구되는 핵심성능의 미충족과 기술성숙도 부족이다. 이러 한 실패의 가능성에 대한 위험관리를 위해서 기술성능측정 관리와 기술성숙도 평가의 수행이 필요하다. 하지만 일반 적인 기술성능측정 관리 기법의 적용은 컴포넌트 수준 이하에 대한 측정으로 시스템 통합의 효과를 반영하는 데는 제한이 있다. 한편으로 시스템 통합에 대한 효과를 반영하기 위한 시스템 성숙도 측정 방법이 제시되었지만 성능과 기술성숙도를 분명하게 연계시키지는 못했다. 따라서 본 연구에서는 컴포넌트 수준으로부터 상방향으로 확대하여 시스템 수준에서의 기술적 성능 달성도 평가방법과 함께 시스템 성숙도를 연계하는 시스템 성능 달성도 측정 기법을 제시하였다. 이를 통해 무기체계개발에서 위험관리에 활용할 수 있게 된다. The recent studies indicated that the major sources of the failure in carrying out the programs of weapon systems development would be the unsatisfaction of the required key performance and also the use of premature technology. As such, to manage the risk during the weapon systems development, the use of the technical performance measurement (TPM) and the technology maturity assessment (TMA) turned out to be necessary. However, the TPM studied so far seems to cover the assessment of performance at the component level only, and thus is insufficient in considering the system integration effect. On the other hand, the system readiness level (SRL) method has been presented by reflecting the effect on system integration, but the system performance and maturity has not been considered. To overcome this, a measurement method is proposed in the paper by utilizing the combined system readiness level and achieved technical performance at the system level. This system performance measure can be useful in managing the risk in the weapon systems development.

무기체계개발에서 작전운용성능을 만족시키기 위한 개선된 시스템성숙도 평가방법

권일호(Kwon, Il-Ho),이재천(Lee, Jae-Chon) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.8

현대 무기체계는 첨단화와 복잡성의 증가로 시스템개발 실패 사례가 빈번하게 발생하고 있다. 사례분석결과 원인은 원래의 시스템 운용개념을 충족시키지 못하거나 미성숙 기술의 적용 등으로 파악되었다. 이에 방위사업청에서 는 무기체계개발시 핵심요구성능으로서 작전운용성능의 충족을 요구하고 있다. 한편 시스템개발시의 위험관리 방법중 의 하나로서 기술성숙도 평가가 사용되어 왔는데, 이것은 개별기술에 대한 평가방법이므로, 시스템 수준에서의 기술 간 통합에 대해서는 미흡하다. 이를 보완하기 위해 시스템 성숙도 평가 모델이 제시되었고, 이와는 별도로 시스템개 발의 난이도의 도입을 통한 리스크 관리 모델이 제시되었다. 하지만 기술간 통합의 효과와 시스템개발 난이도를 동시 에 고려한 모델은 제시되지 않았다. 또한 무기체계개발의 궁극적인 목표인 작전운용성능 충족의 관점에서 도출된 평 가모델은 제시되지 못하였다. 따라서 본 연구에서는 무기체계개발에서 작전운용성능을 충족시키면서 리스크 관리를 수행하기 위한 방법으로, 요소기술간 통합과 시스템개발 난이도를 동시에 고려한 시스템 성숙도 평가 모델을 구축하 였다. 또한 무기체계 연구개발단계에서 개선된 시스템 성숙도 평가모델을 적용할 수 있는 방법을 제시하였다. The risk of failure in the development of modern weapon systems has been increasing as the demand on the capability and the resulting complexity of the weapons on the war fields are increasing drastically. The analysis of failure has indicated that the main causes can be the following: one is attributed to the unsatisfaction of the system operation concept; and the other is the use of premature technology. As such, DAPA in Korea is urging that the weapons systems development should meet the required operational capability (ROC) as a critical performance requirement. On the other hand, an approach to risk management is to use the technology readiness level (TRL) assessed for each individual technology alone. However, the method of TRL cannot assess the effect of integration between technologies and cannot be performed at system level, which is crucial to systems development. In order to improve the shortfalls, a concept of system readiness level (SRL) has been studied by introducing the technologies integration and also some forms of analysis of advanced degree of difficulty studied separately, but no model considering both of two reported yet. In this paper, under the framework of meeting the ROC, an improved SRL assessment model is presented, which is also considering the advanced degree of difficulty simultaneously. The application of the improved assessment method is discussed in connection with the life cycle of the weapon systems development in conformance with the ROC of DAPA.

근골격계질환 예방프로그램의 필요성과 자동차 부품 제조업 근로자들의 근력과 자세의 특성 연구

권일호 ( Il-ho Kwon ),신원섭 ( Won-seob Shin ) 대한물리의학회 2019 대한물리의학회지 Vol.14 No.4

PURPOSE: This study examined the necessity of a musculoskeletal injury-prevention program for automobile parts manufacturing workers by assessing the body composition, muscle strength, and posture according to sex and age. METHODS: Two hundred eighty-two workers (men, 218; women, 64; mean age, 38.97 years; and mean work tenure, 10.29 years) participated in this study. They completed a questionnaire on their general characteristics, excluding personal identification codes. The participants were evaluated for body composition, muscle strength, and posture using InBody, a hand dynamometer, and the Image J program through photography, respectively. An independent t-test and one-way analysis of the variance were used for the comparisons according to sex and age, respectively. RESULTS: Significant sex-related differences in muscle strength and grip force were observed (p<.05). In addition, the left-side pelvic inclination was significantly higher in the female participants than in the male participants (p<.05). Significant age-related differences in the skeletal muscle mass and muscle strength were observed around 40 years (p<.05). Significant correlations were observed among the body composition (skeletal muscle and body fat masses), muscle strength, and posture (pelvic inclination; p<.01). CONCLUSION: Significant differences in pelvic inclination by sex and muscle strength by age were found, even in healthy workers. Additional posture and muscle strength measurements will be needed for workers who participate in the musculoskeletal injury prevention program because they are exposed to an incorrect posture for many hours or in many repetitive tasks.

압력센서를 이용한 감각피드백 균형 훈련이 노인의 정적 균형에 미치는 효과

권일호 ( Il-ho Kwon ),김호 ( Ho Kim ),신원섭 ( Won-seob Shin ) 대한물리의학회 2020 대한물리의학회지 Vol.15 No.2

PURPOSE: This study aimed to determine the most effective feedback condition for static balance in elderly subjects. METHODS: Thirty-eight elderly subjects (12 men and 26 women with a mean age of 77.21 years) participated in this study. They each completed a questionnaire on their general characteristics, excluding personal identification codes. The static balance ability of the participants was evaluated using a Wii Balance Board and the Balancia program (version 2.0). The following three feedback conditions were considered: condition 1 (tactile feedback), condition 2 (visual feedback), and condition 3 (no feedback). One-way repeated-measures analysis of variance was used for the comparisons according to sway length and sway velocity. The statistical significance level was set to α = .05 for all variables. RESULTS: Significant differences in the sway length and sway velocity were observed between the three conditions (p < .05). Significant differences in the sway length were noted in the order of conditions 1, 2, and 3 (p < .05), and significant differences in the sway velocity in the order of conditions 3, 2, and 1 (p < .05). CONCLUSION: Significant differences in static balance ability were observed between the three conditions. In this study, tactile feedback was found to be the most effective feedback for balance training. Owing to aging and impairment of the senses, such as that observed in the tactile receptors, visual receptors, and proprioceptors, it is recommended that elderly subjects participate in balance training.

Behçet 患者의 單球細胞에서 溫淸飮의 cytokine 分泌抑制 효과

임홍진(Hong Jin Lim),황충연(Choong Yeon Hwang),강학천(Hsueh Chuan Chiang),김남권(Nam Kwon Kim),권일호(Il Ho Kwon) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.4

Behc¸et의 患者의 單球細胞에서 溫淸飮의 cytokine 分泌抑制 효과

임홍진,황충연,강학천,김남권,권일호 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.4

Behc¸ets disease is a systemic inflammatory disorder. The etiology and pathogenesis of Behc¸ets disease has yet been fully elucidated but might involve immune dysfunction. Cytokines involved in the regulation of inflammatory reactions and immune responses may play a role in the pathogenesis of Behc¸ets disease (BD). Onchungeum is an Oriental herbal medication, which has been successfully used in Korea for the treatment of BD. This report describes modulation effects of Onchungeum on cytokine production from phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) of Behc¸ets patients by ELISA. Onchungeum significantly inhibited the production of pro-inflammatory cytokines, TNF-α and IL-1β, compared to absence of Onchungeum (by 52.3 1.4% inhibition for TNF-α and 113.5 3.3% for IL-1β, p < 0.001). Onchungeum also inhibited the production of IFN-γ, immunoregulatory Th1 cytokine, by 89.4 0.8% (p < 0.001). The inhibitory effects of Onchungeum on cytokine production showed dose-dependent manner, and the pre-treatment of 1㎎/㎖ Onchungeum had better effects than immunosuppressive drug for treatment of BD, cyclosporin A. Our results suggest that Onchungeum treatment for Behc¸ets disease patients may have pharmacologic activities and abilities of regulation of immune and inflammatory responses by cytokine modulation.