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붉은싸리버섯 추출물의 항산화 및 Human Neutrophil Elastase 저해활성
김관철 ( Kwan-chul Kim ),권용범 ( Yong-beom Kwon ),장해동 ( Hae-dong Jang ),김재화 ( Jae Wha Kim ),정재철 ( Jae Cheol Jeong ),이익수 ( Ik-soo Lee ),하병조 ( Byung-jo Ha ),유익동 ( Ick-dong Yoo ) 대한화장품학회 2016 대한화장품학회지 Vol.42 No.3
천연자원으로부터 항노화 화장품 신소재를 탐색하던 중, 국내 자생버섯의 일종인 붉은싸리버섯 자실체 추출물이 항산화 활성과 인체 호중구 엘라스타제 저해활성이 우수함을 확인하고 일련의 연구를 수행하였다. 붉은싸리버섯 추출물의 DPPH 라디칼 소거활성은 붉은싸리버섯 추출물 500 μ g/mL 처리시 117.0 mg/mL (ascorbic acid 환산값)의 매우 우수한 소거활성을 나타냈다. Peroxy 라디칼 소거활성을 oxygen radical absorbance capacity (ORAC) assay 를 통하여 측정한 결과 붉은싸리버섯 추출물 1, 10, 20 μ g/mL 처리 시, 각각 0.8, 5.2, 7.8 ORAC<sub>Roo</sub> (trolox equivalents, 1 μ M)로 농도 의존적으로 높은 소거활성을 나타냈다. 뿐만 아니라 cellular antioxidant capacity를 DCF fluorescence intensity (% of control)로 조사한 결과에서도 붉은싸리버섯 추출물 20 μ g/mL 처리시 약 30% 이상 높은 항산화 활성을 나타냈다. Human neutrophil elastase 저해활성은 농도 의존적으로 저해활성을 나타냈으며 특히 에탄올 추출분획에서 ED<sub>50</sub> 값은 42.9 μ g/mL이었다. 붉은싸리버섯 추출물은 Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), Candida albicans (C. albicans), Aspergillus oryzae (A. oryzae) 균주 모두에서 항균활성은 나타나지 않았다. 또한 염증성 cytokine인 interleukin-10 및 interferon-γ (IFN-γ)의 생산 또는 분비 조절에는 영향을 미치지 않았다. 이상의 결과로 붉은싸리버섯 추출물은 항산화활성과 elastase 저해활성을 우수하여 피부에 자극이 없는 항노화 화장품 조성물로 유용하게 사용될 수 있음을 확인하였다. In searching for novel agents for skin anti-aging from natural resources, we found that the extract of the fruiting bodies of Ramaria formosa (R. formosa) had significant antioxidant and human neutrophil elastase (HNE) inhibitory activities. R. formosa extract exhibited a considerable DPPH radical scavenging activity with an antioxidant content of 117.0 mg/mL (ascorbic acid equivalents) at the concentration of 500 μg/mL. The capacity of R. formosa extract to scavenge peroxy radicals measured by ORAC assay also showed dose-dependent antioxidant effect with ORAC<sub>Roo</sub> (trolox equivalents, 1 μM) values of 0.8, 5.2, and 7.8 at the concentrations of 1, 10, and 20 μg/mL. The cellular antioxidant capacity of R. formosa extract was investigated by assaying the cellular fluorescence intensity using dichlorodihydrofluorescein (DCF). The cellular oxidative stress induced by AAPH, Cu<sup>2+</sup> or H2O2 in HepG2 cells was significantly attenuated by more than 30% at 20 μg/mL of R. formosa extract. HNE activity was reduced by treatment with R. formosa extract in a dose-dependent manner, and the ED<sub>50</sub> value for the ethanol extract of R. formosa was 42.9 μg/mL. R. formosa extract did not exhibited antimicrobial activity against four microorganisms including Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), Candida albicans (C. albicans), Aspergillus oryzae (A. oryzae). Furthermore, the extract did not affect the inflammatory cytokine production of interleukin-10 and interferon-γ in NK92 cells. From the above results, we found that R. formosa extract has considerable antioxidant and elastase inhibitory effects, and does not stimulate immune cells. These findings suggest that R. formosa extract may be used as a bioactive component in cosmetic composition.
NMED-01과 NMED-02의 간기능 개선에 대한 인체 효능 평가
박상욱 ( Sangwoug Park ),권용범 ( Yong Beom Kwon ),김기태 ( Ki Tae Kim ),신선미 ( Seon Mi Shin ),임강현 ( Kang Hyun Leem ),고흥 ( Heung Ko ),송미경 ( Mi Kyung Song ),정윤철 ( Yoon Chul Jung ),김호철 ( Ho Cheol Kim ),박주연 ( Ju Y 대한본초학회 2013 大韓本草學會誌 Vol.28 No.6
Objectives: The purpose of this study was to determine whether NMED-01 or NMED-02 improves laboratory test results in participants with liver function disorder. Methods : This is a randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded to treatment group. The study was conducted at Semyung university oriental medicine hospital in Jecheon where participants with high level of serum γ-GTP (60-350 U/L) were enrolled. The intervention consisted of three times daily ingestion of either two capsules of placebo, NMED-01 (NeuMed. co. ltd., Seoul), or NMED-02 (NeuMed. co. ltd., Seoul) for twelve weeks. To evaluate the efficacy and safety of NMED-01 and NMED-02, we primarily evaluated the degree of decrement of serum γ-GPT level among three groups. Secondarily the decrement of serum ALT, AST, and triglyceride level in each group were also evaluated. Adverse effects were monitored during the twelve weeks treatment. Results : The change of γ-GTP level of NMED-01 group was lower than that of placebo group at the end of 12-week administration (28.1±38.7 U/L vs. 9.3±27.0 U/L, p=0.046). Other variables including AST, ALT, and triglyceride level were not significantly reduced. The decrement of γ-GPT, AST, ALT, and triglyceride level of NMED-02 group was not significant. There were no significant adverse effects or toxicities during treatment period. Conclusions : Participants receiving NMED-01 had improvement in laboratory test results. Despite a modest sample size, our results suggest that NMED-01 are safe and may be potentially effective in improving liver function. However, NMED-02 have lack of a detectable effect in this study.
Quantum dot LED (QD-LED)와 White-LED 보광에 따른 방울토마토 과실의 품질, 수확량 및 경제성 비교
이주환 ( Joo Hwan Lee ),최담희 ( Dam Hee Choi ),노유한 ( Yoo Han Roh ),권용범 ( Yong Beom Kwon ),아포라비아비오둔사무엘 ( Abiodun Samuel Afolabi ),최인이 ( In-lee Choi ),김용득 ( Yongduk Kim ),신정철 ( Jung Chul Shin ),김민하 ( Minha K 강원대학교 농업생명과학연구원 2022 강원 농업생명환경연구 Vol.34 No.0
본 연구는 햇빛을 대조구로 설정하고 White 및 QD-LED를 이용하여 방울토마토의 군락 위 보광을 하였으며, 과실의 수확량 및 내·외적 품질변화에 대해 알아보고 경제적이며 효과적인 광원을 선발하기 위해 수행하였다. 인공광원을 통한 보광은 대조구보다 평균 45.4% 광도를 높였으며 Fv/Fm은 9.2% 증가했다. 광도 변화와 함께 광원의 광질에 따라서도 차이를 보였는데, QD-LED에서 가장 높은 a*/b*값으로 White-LED 및 대조구보다 변색기의 진행이 빨라 숙기가 가장 많이 단축됨을 알 수 있었다. 또한 과장, 과폭, 과실수, 과방무게에서 보광처리구가 대조구보다 높은 값을 보였으며, 그 중 QD-LED가 결과값이 가장 높았다. 당도는 같은 기간 내 성숙이 가장 빨랐던 QD-LED가 가장 높았고 산도 및 경도는 가장 낮았다. DPPH 라디컬 소거능과 Ascorbic acid는 보광처리가 대조구보다 높은 값을 보였고 보광처리구에서는 QD-LED가 White-LED보다 더 좋은 효과를 나타냈으며, 기형과 발생률도 QD-LED에서 가장 낮았다. 두 광원의 경제적인 측면을 고려할 때 QD-LED는 White-LED에 비해 상대적으로 전력 소비가 적고 비용이 저렴하며 에너지 사용 효율이 훨씬 높았다. 이 모든 요소를 종합하면 방울토마토의 군락 위에 대한 보광은 효과적이며 광원으로는 QD-LED를 사용하는 것이 가장 적합하다고 판단된다. This study was conducted to investigate the yield of fruits and changes in internal and external quality, and to select an economical and effective light source. Sunlight was set as a control, and lights were supplemented on the upper canopy of cherry tomatoes (Solanum lycopersicum var. cerasiforme) using white and QD-LED. The supplemental light through the artificial light source increased the light intensity by 45.4% on average compared to the control, and the Fv/Fm increased by 9.2%. There was a difference in light quality as well as a change in light intensity, and it was found that the QD-LED with the highest a*/b* value progressed faster at the breaking stage and the maturation period was greatly shortened compared to that of White-LED and the control. The supplemental lighting treated group showed higher values than the control group for length, width, number of fruit, and weight of cluster, and among them, QD-LED showed the highest value. The QD-LED, which matured tomatoes the fastest within the same period, resulted in the highest soluble solids and the lowest titratable acidity and firmness. For DPPH radical scavenging activity and ascorbic acid, the supplemental lighting treatment showed higher values than the control group, and QD-LED showed better effects than White-LED in the supplemental lighting treatment. Additionally, the malformed fruit incidence rates were the lowest in QD-LED. Considering the economical aspect of both light sources, the QD-LED showed a relatively lower electrical power consumption, lower cost, and a much higher energy use efficiency than White-LED. We conclude that supplemental lightning on the upper canopy of cherry tomatoes is effective and QD-LED is the most suitable for use.