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Design of A Portable Optical Biosensor System for Light Scattering Immunoassay
Da-In Kwon(권다인),Jae-Hwan Oh(오재환),Sang-WonWoo(우상원),Yeong-Eun Yoo(유영은),Do Hyun Kang(강도현) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
We developed a portable optical biosensor system integrated with a thermoplastic microfluidic device for point-of-care light scattering immunoassay. In our design, the bead-based immunoassay is performed inside the T-channel microfluidic mixing device, and then the scattered light signal is generated and monitored in real-time by a 365 nm of flat microLED and a photodetector. The microfluidic device is combined with a thin pinhole structure to increase signal-to- noise ratio. We reveal that, at a certain optimized detection angle, the pinhole structure can efficiently filter the scattered photons by dramatically screening the incident lights. Due to this unique design, the overall system was successfully miniaturized to a portable optical biosensor system with Bluetooth-based wireless communication to PC or smartphones. We have applied our biosensor system to construct various point-of-cate diagnosis tests from biotin-avidin interaction to virus identification.
적층 방식 3차원 프린팅에 의한 미세유로 칩 제작 공정에서 프린팅 방향 및 적층 두께의 영향에 관한 연구
진재호,권다인,오재환,강도현,김관오,윤재성,유영은 한국금형공학회 2022 한국금형공학회지 Vol.16 No.3
Micro-fluidic chip has been fabricated by lithography process on silicon or glass wafer, casting using PDMS, injection molding of thermoplastics or 3D printing, etc. Among these processes, 3D printing can fabricate micro-fluidic chip directly from the design without master or template for fluidic channel fabricated previously. Due to this direct printing, 3D printing provides very fast and economical method for prototyping micro-fluidic chip comparing to conventional fabrication process such as lithography, PDMS casting or injection molding. Although 3D printing is now used more extensively due to this fast and cheap process done automatically by single printing machine, there are some issues on accuracy or surface characteristics, etc. The accuracy of the shape and size of the micro-channel is limited by the resolution of the printing and printing direction or layering direction in case of SLM type of 3D printing using UV curable resin. In this study, the printing direction and thickness of each printing layer are investigated to see the effect on the size, shape and surface of the micro-channel. A set of micro-channels with different size was designed and arrayed orthogonal. Micro-fluidic chips are 3D printed in different directions to the micro-channel, orthogonal, parallel, or skewed. The shape of the cross-section of the micro-channel and the surface of the micro-channel are photographed using optical microscopy. From a series of experiments, an optimal printing direction and process conditions are investigated for 3D printing of micro-fluidic chip.
Ultrasound Image Stitching Algorithm to Identify Anatomical Risk Factors for Lateral Epicondylitis
Seokki Kim(김석기),Dain Kwon(권다인),Yeseop Park(박예섭),Youkeun Oh(오유근) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
In general, structures with acute angles are vulnerable to stress concentrations. These structures can be found in the tendon/ligament-to-bone interface, known as enthesis. Our previous study showed that the stress concentration occurred near the ACL femoral enthesis. This implies that ACL injuries could occur if loading cycles above a certain level of threshold are repeated. The extensor tendons of forearm have a similar insertion structure. It is pulled and lifted when the extensor muscle of the forearm contracts. Therefore, if the forearm is overused due to repetitive or strenuous activities, it could be damaged by a mechanism similar to the ACL injuries at the femoral enthesis. However, these injuries require the use of expensive equipment (MR image, radiograph) in a limited environment for diagnosis. In this study, experiments are conducted to observe through a portable ultrasound scanner. The ultrasound (US) image can directly grasp the shape of the muscle, and the structural causes of tennis elbow can be observed. We propose an algorithm to conveniently observe the appearance of muscles and tendons using an ultrasound scanner. US images of the forearm extensor tendons from 5 experimental participants are obtained. The images are stitched into a panoramic image, then images are analyzed to measure the angle between the extensor tendon and bone surface.