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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
권다솔,Byung-Seok Kim,정연석 대한면역학회 2020 Immune Network Vol.20 No.1
IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8+ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.
자율주행 시 비운전 과제 모달리티가 운전자 스트레스 및 운전성능에 미치는 영향 분석
권다솔(Dasol Kwon),정의승(Eui S. Jung) 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.3
Objective: The aim of driving simulator study is to investigate interactions between driver behaviors and the automated vehicles according to non-driving related tasks modality and traffic density. Background: With the addition of a greater number of advanced driver assistance systems in vehicles, the driver has an opportunity to have non-driving related tasks during autonomous driving. Understanding the implications of such advancements on driving behaviors and road situations is important for safety. Method: 20 participants were recruited to measure take-over reaction time, lateral position, and Short Stress State Questionnaire (SSSQ) under different traffic conditions of suggesting NDRT modalities. As well as comparing the effects of traffic complex while doing different NDRT, the effect of NDRT modalities were also investigated. Results: Traffic density showed minor effects on driving performance and SSSQ results. However, NDRT modalities have differences: auditory NDRT modalities led to shorter takeover reaction times and higher task engagement. Conclusion: For the design and evaluation of human-automation interaction in conditionally automated driving systems, NDRT modalities seems to play a major role, compared to the traffic density. Application: The present results can be used to appropriately design human-automation interfaces considering NDRT modalities.