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Sidelines for the dermatologists: strength and opportunity
구본철 ( Boncheol Leo Goo ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Sidelines were thought to be distracting for the day jobs, especially for the people working with their specialties, like dermatologists. However, academic, clinical and industrial issues are always influencing each other and cannot be separated. For the specialists, they have not only the opportunity, but also the responsibility because when they are not doing their proper roles in this ecosystem, other non-specialist take their roles and ruin the whole world, and finally the make the specialists lose their prestige.
구본철(Boncheol-Leo Goo),송다혜(Da-Hye Song),최유진(Yu-Jin Choi),오교녀(Kyo-nyeo Oh),오둘리(Dool-Ri Oh),홍지애(Ji-Ae Hong),김은정(Eun-Joung Kim) 한국생약학회 2023 생약학회지 Vol.54 No.4
Skin aging is caused by structural changes in the extracellular matrix (ECM) due to internal and external factors. It is characterized by decreased skin moisture, increased skin roughness, increased skin wrinkles, and decreased skin elasticity. In this study, Elastase and Collagenase inhibitory activities and SOD, CAT, and GSH-Px activities were confirmed in HaCaT cells, and Collagen-I content and skin elasticity were also confirmed in response to UVB irradiation in HR-1 hairless mice. In addition, a double-blind, randomized, placebo-controlled study was conducted on the effects of oral administration of NP-2007 in 84 women. In the group that consumed NP-2007 or placebo, the amount of skin moisture, trans-epidermal water loss (TEWL), mass of skin keratin, skin asperity (Ra, Rz), eye wrinkle, and skin elasticity were checked. Compared to the placebo group, significant changes were confirmed at all-time points after 6 and 12 weeks of intake. This study was investigated the potential of oral administration of NP-2007 as a functional food material that improves skin.