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위장관 ( 胃腸管 ) : 식도 정맥류 출혈시 내과적 치료 효과
김성록(Sung Rok Kim),곽규식(Kyu Sik Kwak),정준모(Jun Mo Chung),탁원영(Won Young Tak),윤영미(Young Mee Yun),안병철(Byung Chul An),최용환(Young Hwan Choi) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A We studied the variances affecting the survival rate and duration of rebleedling after treatment in three medical treatment methods (conventional medical treatment, endoscopic sclerotherapy, and percutaneous transhepatic obliteration), and also their effectiveness of bleeding control in 130 eso- phageal varices bleeding cases in liver cirrhosis. Among 130 cases of esophageal varices bleeding, 60 cases are treated with esophageal varices sclerotherapy, 54 cases are by conservative management, and 16 cases are by percutaneous esophageal varices obliteration method. The results obtained are as follows; 1) The significant variances affecting the survival rate are Childs classification, number of rebleed ing and transfusion, serum ALT and protein level, and association with hepaoma or not(p<0.05). 2) The important variances which affecting the duration of rebleeding after first treatment are the esophageal variceal degree, and association with hepatoma (p < 0. 05), and also the method of sclerotherapy is more effective than others at Wilcoxon analysis, but disclosed no significant variances at Cox regression method. 3) Bleeding is the most common cause of death after variable medical treatment.
최용환(Yong Hwan Choi),곽규식(Kyu Sik Kwak),정준모(Jun Mo Jung),이경수(Kyung Su Lee),박재용(Jae Yong Park),김은영(Eun Young Kim) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A For evaluating the efficacy of teprenone for gastric ulcer, we prescribed 50 mg of teprenone orally three times daily for 16 gastric ulcer patients and done follow up studies including gastric and biochemical tests. The results obtained were as follows: 1) Gastroscopic examination revealed remarkable improvement in 31.3% and moderate improvement in 25.0% of patients during 8 weeks. 2) Subjective symptoms such as epigastric pain, nausea, vomiting, anorexia and belching were subsided from 68.8% to 100% of patients. 3) No remarkable side effect were noted. These results suggest that teprenone is one of effective therapeutic drugs for gastric ulcer patients.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 간경변증을 동반한 간암 환자에 있어서 혈청 Complement의 진단적 의의
최용환(Yong Hwan Choi),김성록(Sung Rok Kim),곽규식(Kyu Sik Kwak),박재용(Jae Yong Park),김은영(Eun Young Kim),정준모(Jun Mo Chung),탁원영(Won Young Tak),송달효(Dal Hyo Song) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
N/A To evaluate the diagnostic accuracy of serum complement level as an early diagnostic tool of hepatocellular carcinoma in cirrhotic patient, we examined 22 cases of liver cirrhosis and 16 cases of liver cirrhosie with hepatocellular carcinama. The results are as follows; 1) In liver cirrhosis with hepatocellular carcinoma, serum complement level was higher than liver cirrhosis. 2) When the serum cornplement levels, C3; 61 mg/dl and C4; 41 mg/dl, were indicated as the cutoff value in differential diagnosis of liver cirrhosis and hepatocellular carcinoma with liver cirrhosis, the poeitive predictive value, negative predictive value, and accuracy were 90%, 75%, and 79%, respectively. 3) When in serum AFP level, the cutoff value was disclosed as 400 ng/ml, the positive predictive value, negative predictive value, and accuracy of serum alpha fetoprotein were 100%, 31%, and 74% respectively, 4) Considering combination of above described data of serum C3, C4 and AFP, the positive predietive value, negative predictive value, accuracy were 92%, 81%, 84% respectively. Based on these data, serum complement level may be used as a valuable tumor marker in the die oais of hepatocellular carcinoma in cirrhotic patient eapecially when it is considered together with rum alpha fetoprotein level.
이승철(Sung Chul Lee),황현석(Hyun Suk Hwang),김보완(Bo Wan Kim),곽규식(Kyu Sik Kwak),최용환(Yong Hwan Choi),정준모(Joon Mo Chung) 대한내과학회 1987 대한내과학회지 Vol.32 No.4
N/A To investigate the prevalence of peptic ulcer in diabetics and the relation between peptic ulcer in diabetics and glycosylated hemoglobin (G-Hb) level, chronic complications, and mode of therapy, gastrofiberscopic examination was done in 62 patients with type II diabetes. Peptic ulcer was found in 8 cases (12.9%); gastric in 5, duodenal in 2 and gastroduodenal in 1. It seemed that the association of peptic ulcer was not related to G-Hb level, presence of retinopathy or peripheral neuropathy, and also mode of therapy. These findings suggest that there is no remarkable relation between the incidence of peptic ulcer and hyperglycemia, microangiopathy, neuropathy or mode of theapy in diabetes.
김효석(Hyo Suk Kim),박재용(Jae Young Park),김은영(Eun Young Kim),곽규식(Kyu Sik Kwak),최용환(Young Hwan Choi),정준모(Joon Mo Chung) 대한내과학회 1989 대한내과학회지 Vol.36 No.4
N/A In order to investigate the morphologic changes of hepatocytes after ligation of the common bile duct, we doubly ligated and cut the common bile duct of male Sprague-Dawley rats and observed the changes of the liver by light microscope, transmission and scanning electron microscope at 2,4,6 and 8 week after ligation. The results were as follows: Under the light microscope, we noted marked ductular proliferation anc1 fibrosis with chronic inflammatory infiltration in the widened portal area at 2 weeks after ligation, which later became more prominent and invaded the periphery of the lobule and centrilobular area, until 6 weeks, when early cirrhosis was established. On examination under the election microscope, we noted and increment in the amount of smooth endopalsmic reticulum, hyperplasia and distension of the Golgi apparatus, an increment of lysosomes, widening of the pericanalicular ectoplasm, a slight swelling of mitochondria and decrement of cristae at 2 weeks after ligation. The bile canaliculi were dilated remarkably and their micromilli were decreased in number or absent at 2 weeks after ligiation. Also, a phenomenon referred to as canalicular varicositv was noted which later became more severe but the tight junction was rather well preserved. The results of this study suggest that recognizable early cirrhotic change of the liver is established at 6 weeks after common bile duct ligation, and that canalicular varicosity is one of the characteristic ultrastructural changes of hepatocytes after common bile duct ligation. The mechanism of cholestasis must also be considered as well as the other possible routes, including the passway from bile canaliculus to sinusoid.
흰쥐에서 Cimetidine 투여가 알코올 대사에 미치는 영향
김재왕(Jae Wang Kim),정준모(Joon Mo Chung),최용환(Yong Hwan Choi),곽규식(Kyu Sik Kwak),권영오(Young Oh Kweon),김호각(Ho Gack Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.3
N/A For a study of the effects of cimetidine on ethanol metabolism, administered ethanol to male Sprague Dowley rats 1) 3 gm/kg per orally, 2) 1 gm/kg intraperitoneally and 3) 7 gm/kg intraperitoneally in each group, and checked serum ethanol concentration and ethanol concentration time curve, One week later, pretreated 120 mg/kg of cimetidine intraperitoneally and, 30 minutes later, administered ethanol to the same rets of each groups and also performed above described examination. The results obtained were as followed, The peak serum ethanol concentration (178.0±41.9 vs. 159.2±40.6mg%, P<0.05) and the area under serum ethanol concentration time curve (1013.2±364.8 vs. 755.4±257.3mg%hr, P<0.02) were significantly increased when cimetidine was introduced in the group with single oral dose of ethanol (3 gm/kg) and also when ethanol (1.0 gm/kg) was administered intraperitoneally, cimetidine produced a significant increase in the peak serum ethanol concentration (91.0±7.5 vs, 79.6±10.8mg%, P<0.05) and the area under sercum ethanol concentration time curve (142.5±185.5 vs. 104.4±20.0mg%hr, P<0.001). Serum ethanol elimination rate (105.5±10.4 vs. 151.7v21.3 mg% kg-1 hr-1, P<0.05) was much decreased in those had cimetidine pretreatment and ethanol administration per orally (7 gm/kg), especially at high ethanol concentration those are above 140 mg%. These results suggest that cimetidine should be prescribed with caution in alcoholics with upper gastrointestinal tract trouble.
간장및 담도 : B형 간염 바이러스에 의한 만성활동성 간염 환자에서 알파 인터페론의 치료 효과
최용환(Yong Hwan Choi),김성록(Sung Rok Kim),곽규식(Kyu Sik Kwak),박재용(Jae Yong Park),김은영(Eun Young Kim),정준모(Jun Mo Chung),탁원영(Won Young Tak) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
N/A This study was designed to estimate the efficacy and safety of IFN-alpha in type B chronic active hepatitis patients. Thirty two cases were subcutaneously injected with IFN-alpha daily 3,000,000 units, three time a week for 12 weeks. The drug was administered while the patients were in the hospital for the first week, who were followed up after discharge once every month for four months. The follow-up continued for a maximum of 14 months depending on the conditions of the cases (mean +- SD: 7.3 +- 5.0 months). Twenty five cases, as a control group, were not treated with IFN-alpha and observed for 3 to 18 months (mean +- SD: 7.6 +- 3.4 months). The results were as follows. In the patients treated with IFN-alpha, disappearance of HBe antigen was observed in 9 of the 32 cases (28.1%), and anti-HBe appeared in 8 of 9 cases (8/32:25.0%). In the control group, disappearance of HBe antigen showed in 4 of 25 cases (16.0%). Of the 4 cases, one showed anti-HBe (1/25:4.0%). No significant difference of disappearance of HBe antigen between the two groups. Signifirant difference, however, was noted in the appearance of anti-HBe. Follow-up was made on serum HBV-DNA titer in 15 cases injected with IFN-alpha. The levels were lowest between two to three months in 12 cases, and in four months of the follow-up in one case. Five cases converted to negative, in all 5 cases HBe antigen disappeared. The seronegative ratio of the two groups showed no significant difference in family history of type B hepatitis, age, sex, histologic finding, initial HBV-DNA titer and aminotransferase level. The serum transferase level in the group with IFN-alpha treatment made a remarkable decrease after 4 weeks of treatmen. In control group, aminotransferase decreased but not significantly during follow-up. All patients treated with IFN-alpha complained of fever, myalgia and other minor side effects not serious as to require treatment. Thus this findings suggest that treatment of type B chronic active heaptitis patients with IFN-alpha 3,000,000 units daily, three times a week for 12 weeks appears to be a safe and relatively effective way.