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전신홍반루푸스 환자에서 발생한 진행성 다초점 백색질 뇌증
고훈영 ( Hoon Young Ko ),민준기 ( Jun Ki Min ),김혜강 ( Hye Kang Kim ),이희연 ( Hee Yeon Lee ),심용수 ( Yong Soo Shim ),김지영 ( Jee Young Kim ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.2
Progressive multifocal leukoencephalopathy (PML) is a rare, serious, and usually fatal demyelinating disease that occurs predominantly in severely immunosuppressed patients. The disease is caused by the infection of oligodendrocytes with JC virus that is widely distributed as a latent infection in the general populations. PML has been described mainly in patients infected with the human immunodeficiency virus. However, other immune-suppressed patients including malignancies and organ transplants can be affected with JC virus infection. Recently it is suggested that rheumatologic diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, dermatomyositis, polymyositis, wegener`s granulomatosis be known to be at risk of developing PML. We report a case of PML in a patient with SLE.
천식환자에서 병발된 S 단백 결핍과 연관된 폐동맥 색전증
박정화 ( Chung Hwa Park ),윤승배 ( Seung Bae Yoon ),김대범 ( Dae Bum Kim ),이한희 ( Han Hee Lee ),김찬준 ( Chan Joon Kim ),김정호 ( Jeong Ho Kim ),고훈영 ( Hoon Young Ko ),이미정 ( Mi Jeong Lee ),이화정 ( Hwa Jeong Lee ),김승수 ( 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.2
Asthma is a chronic multifactorial disease with frequent exacerbations in many patients. Much effort has been made to determine prevalent factors associated with difficult- to-control asthma. Here we report the case of a 57-year-old man who was treated for asthma during the last 4 years at our pulmonology clinic. Recently, the patient experienced severe dyspnea for more than 3 months despite the addition of the leukotriene modifier, theophylline and oral cortic- osteroid. Chest CT scans revealed multifocal areas of pulmonary arterial thrombosis. Doppler ultrasonograms showed multiple deep vein thrombi. The patient was diagnosed of having protein S deficiency and was treated with low molecular weight heparin, followed by oral warfarin. Now, he has no pulmonary arterial thrombosis and has no more asthmatic attack for half a year. (Korean J Asthma Allergy Clin Immunol 2010;30:135-139)