http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
고석태,이민재,허영근,Ko, Suk-Tai,Lee, Min-Jae,Hur, Young-Keun 대한약학회 1989 약학회지 Vol.33 No.3
Angiotensin II, adminstered (infused or injected) intravenously, elicited the antidiuretic action with the decreased parameters of renal function at a small dose ($0.01\;{\mu}g/kg/min$), whereas, at a large dose (0.03, $0.1\;{\mu}g/kg/min$ and $5.0\;{\mu}g/kg$), it produced the diuretic action accompanied the increased amounts of sodium and potassium excreted in urine ($E_{Na}\;and\;R_K$). At this time, glomerular filtration rates (GFR) were weakened slightly and renal plasma flows (RPF) were reduced markedly, and then filtration fractions (FF) were increased. Angiotensin II, infused into a renal artery, exhibited antidiuretic action at a small dose ($0.003\;{\mu}g/kg/min$), and diuretic action at a large dose ($0.01\;{\mu}g/kg/min$), only in infused (experimental) kidney. The mechanism of the action was similar to the cases of the intravenous angiotensin II. The above results suggest that angiotensin II of a large dose produced diuretic action due to mechanism inhibiting reabsorption of electrolytes in renal tubules, mainly in proximal tubule in dog.
Debrisoquine이 가토신장기능(家兎腎臟機能)에 미치는 영향(影響)
고석태,박정희,Ko, Suk-Tai,Park, Jung-Hee 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.2
The action of debrisoquine on renal function in rabbits was studied. 1. When debrisoquine was given into ear vein, it did not affect on renal functin with smaller doses of 0.1 or 0.3mg/kg, while with higher dose of 1.0mg/kg it elicited the significant decrease of urine flow, renal plasma flow and glomerular filtration rate, and the increase of filtration fraction, and at the same time sodium excreted in urine, FENa (fractional excretion of sodium) and osmolar clearance were significantly decreased, and then it exhibited the increase of $K^+/Na^+$ ratio and no changes of $T^cH_2O$. 2. Debrisoquine (1.0mg/kg), when injected repeatedly into a vein, produced a more marked decrease of urine flow. 3. Debrisoquine induced-antidiuretic action was not affected by pretreatment with phentolamine (2mg/kg, i.v.), alpha-sympathetic blocking agent. 4. Debrisoquine given intracerebroventricularly did not produce a significant change on renal function in dose of 0.1mg/kg. These results suggest that debrisoquine produce the antidiuretic effect in rabbit, and the mechanism of its action is due to dual actions that are the decrease of hemodynamic effect and the facilitation of reabsorption of sodium in renal tubules.
K+ Channel 개방제인 BRL 34915의 신장작용
고석태(Suk Tai Ko),최홍석(Hong Seok Choi) 대한약학회 2000 약학회지 Vol.44 No.3
The effect of BRL 34915, a K+ channel opener, on renal function was investigated in anesthetized dog. BRL 34915, when given into the vein, elicited the decrease of urine volume accompanied with the reduction of renal plasma flow (RPF), osmolar clearance (Coosm) and amounts of sodium excreted into urine (ENNa), whereas reabsorption rate of sodium in renal tubules (RNa), ratio of K+ against Na+ in urine (K+/Na+) were elevated significantly with a partial fall of mean arterial pressure (MAP). BRL 34915 injected into a renal artery produced the diuretic action along with the increase in RPF, COSM, EN, and amounts of potassium excreted in urine (EK), and the decrease in RNa, reabsorption rate of potassium in renal tubules (RK), free water clearance (CH20) and K+/Na+ ratio in only ipsilateral kidney, however changes of the renal function were not observed in control kidney. BRL 34915 given into carotid artery exhibited the same aspect as changes of renal function induced by intravenous BRL 34915. These results suggest that BRL 34915 has dual effects, renally acting diuretic and centrally acting antidiuretic action.
Diaminocyclohexane 을 배위자로 한 새로운 항암성 백금 (2) 착체류의 일반약리작용
고석태(Suk Tai Ko),강선영(Seon Yung Kang),임동윤(Dong Yoon Lim),신현준(Hyun June Shin),이승기(Seung Ki Lee),노영수(Young Soo Rho),정지창(Jee Chang Jung) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
The general pharmacological properties of new platinum (II) coordination complexes, SA : [Pt (trans-ℓ-DACH)(DPPE)]·2NO₃, SB : [Pt(cis-DACH)(DPPP)] ·2NO₃ and SC : [Pt(cis-DACH)(DPPE)] ·2NO₃ on central nervous, respiratory, cardiovascular and digestive systems were studied in various experimental animals. These platinum (II) anticancer agents had no effects on analgesia, thiopental-induced sleeping time, body temperature, strychnine-induced convulsion, inflammation and local anesthetic action in mice and rats. Intestinal motility, stomach-ulcer induced by serotonin and bile-secretion of rats were not influenced by the dose of 30 ㎎/㎏. However SB and SC induced a mild decrease in heart rate in anesthetized rats. Based on these results, these new platinum (II) complexes may be regarded as a valuable lead compound in the development of new anticancer chemotherapeutic agents with marked antitumor activity and low toxicity.
가토에서 혈압에 관여하는 약물의 작용에 대한 니페디핀의 영향
고석태(Suk Tai Ko),정창주(Chang Ju Jung),김해석(Hai Suk Kim) 대한약학회 1992 약학회지 Vol.36 No.4
In order to investigate the effect of nifedipine, Ca2+ channel antagoninst, on the action of some drugs participating in blood pressure, this experiment was performed in rabbits. Nifedipine decreased the pressor actions of norepinephrine, angiotensin and carotid artery clamping, but did not affect the pressor actions of tyramine and depressor actions of acetylcholine and pilocarpine. Nifedipine inhibited the potentiated pressor action of norepinephrine and angiotensin, but did not influence the potentiated pressor action of tyramine in rabbits pretreated with chlorisondamine, ganglionic blocking agent. Nifedipine weakened the potentiated pressor action of norepinephrine, did not affect the pressor action of angiotensin and the potentiated pressor action of tyramine in rabbits pretreated with debrisoquine, sympathetic neuronal blocking agent.
K+ Channel 개방제인 BRL 34915의 신장작용에 대한 신장 신경제거와 선택성 ATP-의존성 K+ Channel 차단제인 Glibenclamide의 영향
고석태(Suk Tai Ko),최홍석(Hong Seok Choi) 대한약학회 2000 약학회지 Vol.44 No.4
In anesthetized dogs, antidiuretic action of intravenously administered BRL 34915 (10.0~30.0mcg/kg) was blocked by renal denervation, whereas it was not affected by glibenclamide, a selective KATP blocker, given into renal artery. Diuretic action in ipsilateral kidney produced by intrarenal administration of BRL 34915 was not influenced by renal denervation, but blocked completely by glibenclamide given into the vein. Above results suggest that the antidiuretic action of BRL 34915 is mediated by renal sympathetic nerves and the diuretic action is caused by opening of K+ channel within kidney.
고석태(Suk Tai Ko),유강준(Kang Jun Yu),신동숙(Dong Sook Shin),이수연(Soo Hyan Lee) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
This study was performed in order to certify the antidiuretic action and to investigate the mechanism of antidiuretic action of debrisoquin infused into a renal artery in dog. Debrisoquin, when infused into a renal artery, exhibited the antidiuretic action accompanied the reductions of glomerular filtration rate and renal plasma flow, and the decreased amounts of sodium and potassium excreted in urine, limited only to the infused side, while control kidney function remained unchanged at all. The antidiuretic action of debrisoquin infused into a renal artery was blocked by pretreament of prazosin, α₁-adrenergic blocking agent, or reserpine, catecholamine depleting agent. These results suggest that debrisoquin infused into a renal artery elicits antidiuretic action through indirect stimulation of renal sympathetic nerves.
니트릭옥사이드의 합성 억제제인 NG-니트로-L-아르기닌의 신장작용
고석태(Suk Tai Ko),유강준(Kang Jun Yu),황명성(Myung Sung Hwang) 大韓藥學會 1998 약학회지 Vol.42 No.5
This study was performed in order to investigate the effect of renal function of NG-nitro-L-arginine (L-NOARG), inhibitor of nitric oxide (NO) synthase, in dog and rabbit. L-NOARG, when given intravenously in dogs, exhibited the decrease in urine flow (vol), renal plasma flow (RPF), osmolar clearance (Cosm) and amounts of sodium and potassium excreted in urine(ENa, EK). These renal functions of L-NOARG showed the same aspect in rabbit, too. L-NOARG, when administered into a renal artery, showed the same pattern as was obtained when given intravenously in both experimental and control kidney in dog. L-NOARG administered into the carotid artery showed the decrease in Vol, RPF, ENa, in a low doses that did not show any effect when given intravenously. Above results suggest that L-NOARG produces antidiuretic action in dog and rabbit, and these antidiuretic actions may be mediated by central action.