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        The Mitochondrial DNA 5178 A/C Polymorphism inElite Korean Male Athletes

        강병용,강친양,김재현,김기태,이강오 한국유전학회 2003 Genes & Genomics Vol.25 No.3

        In view of the important role of human mitochondrial DNA (mtDNA) as candidate for athletic performance, we investigate the mt5179=8 A/C polymorphism of the mtDNA in the elite Korean male athletes and sedentary male controls. Total genomic DNA was isolated from 100 elite Korean male athletes and 64 sedentary male controls. The mt 5178 A/C polymorphism was analyzed by polymerase chain reaction (PCR) and Alu I restriction fragment length polymorphism (RFLP) method. This polymorphism was not significantly associated with Vo2max index in elite male athletes under this study. However, the excess of A allele in marathon runners was also observed among our sporting disciplines, although no statistical significance. Further studies using larger sample size wlill be required to clarify the relatihiionship between this genetic variation of mtDNA and athletic performance

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