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RISS 인기검색어
- 검색키워드
- 저자 : 강준기 ( Joon Gi Kang ) (검색결과 2 건)
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김성림,이경진,조정기,나형균,박해관,강준기,최창락,Kim, Seong-Rim,Lee, Kyung Jin,Cho, Jeong Gi,Rha, Hyung Kyun,Park, Hae Kwan,Kang, Joon Ki,Choi, Chang Rak 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1
Objective : DREZotomy is effective for the treatment of deafferentation pain as a consequence of root avulsion, postparaplegic pain, posttraumatic syrinx, postherpetic neuralgia, spinal cord injury, and peripheral nerve injury. We performed microsurgical DREZotomy to the patients with deafferentation pain and relieved pain without any serious complication. The purpose of this study is to evaluate the usefulness of the microsurgical DREZotomy for deafferentation pain. Methods : We evaluated 4 patients with deafferntation pain who were intractable to medical therapy. Two of them were brachial plexus injury with root avulsion owing to trauma, one was axillary metastasis of the squamous cell carcinoma of the left forearm, and the last was anesthesia dolorosa after surgical treatment(MVD and rhizotomy) of trigeminal neuralgia. Preoperative evaluation was based on the neurologic examination, radiologic imaging, and electrophysiological study. In the case of anesthesia dolorosa, we produced two parallel lesions in cephalocaudal direction, 2mm in distance, from the C2 dorsal rootlet to the 5mm superior to the obex including nucleus caudalis, after suboccipital craniectomy and C1-2 laminectomy, with use of microelectrode. In the others, we confirmed lesion site with identification of the nerve root after hemilaminectomy. We performed arachnoid dissection along the posterolateral sulcus and made lesion with microsurgical knife and microelectrocoagulation, 2mm in depth, 2mm in distance, to the direction of 30-45 degrees in the medial portion of the Lissauer's tract and the most dorsal layers of the posterior horn at the one root level above and below the lesion. Results : Compared with preoperative state, microsurgical DREZotomy significantly diminished dosage of the drugs and relieved pain meaningfully. One patient showed tansient ipsilateral ataxia, but recovered soon. There was not any serious complication. Conclusion : It may be concluded that microsurgical DREZotomy is very useful and safe therapeutic modality for deafferentation pain, especially segmentally distributed intermittent or evoke pain. Complete preoperative evaluation and proper selection of the patients and lesion making device are needed to improve the result.
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임상 : 악성뇌교종의 항암 및 방사선 병합치료의 효과와 독성
임동환 ( Dong Hwan Lim ),전신수 ( Shin Soo Jeun ),박춘근 ( Chun Geun Park ),강준기 ( Joon Gi Kang ),김문찬 ( Moon Chan Kim ),홍용길 ( Yong Kil Hong ) 대한뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.1
Objective￡ºConcurrent chemotherapy and radiotherapy trials have been reported to increase anti-tumoral effect and toxicity in several solid cancers, but little has been known in brain tumors. We analyzed clinical efficacy and toxicity of the concurrent therapy as a first line modality in malignant glioma patients. Methods￡ºFrom March 1998 to December 2003, twenty- five patients were enrolled in this study. They are composed of 11 glioblastomas(GBM), 8 anaplastic astrocytomas(AA), 5 anaplastic oligodendrogliomas(AO), and 1 anaplastic oligoastrocytoma(AOA). Mean age was 45.3(19-67) years old with 14 females and 11 males. Both radiotherapy and chemotherapy, composed of BCNU(120mg/m2) or CCNU(75-110mg/m2), procarbazine(60mg/m2) and vincristine(1.4 mg/m2), started simultaneously within 2 weeks after surgery. Results￡ºMedian progression-free survival time(PFS) was 9 months for the patients with GBM, and 19 months for the patients with Non-GBM. Grade III/IV leukopenia developed in 7 of 25(28%) patients and thrombocytopenia in 2 of 25 (8%). Radiation necrosis occurred in 3 patients(12%). Conclusion￡ºConcurrent chemoradiotherapy improved PFS in high-grade glioma patients and its toxicity was tolerable. These preliminary results suggest that further studies would be warranted to improve the clinical efficacy of this therapy in malignant gliomas.
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