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새로운 간질환치료제(고덱스 : 헤파디프에스)의 랫드에 대한 4주반복투여 경구독성시험
강종구(Jong-Kii Kang),정은용(Eun-Yong Jung),박선희(Sun-Hee Park),김선희(Sun-Hee Kim),이수해(Su-Hae Lee),장호송(Hu-Song Zhang),황재식(Zai-Zhi Huang),남상윤(Sang-Yoon Nam) 한국독성학회 2001 Toxicological Research Vol.17 No.2
This study was designed to evaluate a repeated oral dose toxicity of a new hepatotherapeutic agent GODEX in Sprague-Dawley rats. Male and female rats were orally administered with dosages of 500, 100, 20, and a mg/kg/day of GODEX daily for 4 weeks, respectively. There were no dose-related changes in clinical signs, body weight changes, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with GODEX. Gross and histopathological findings revealed no evidence of specific toxicity related to GODEX. These indicate that GODEX may have no side effects and its oral maximum tolerated dose value may be over 500 mg/kg in rats.