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한국산 생약으로부터 항암물질의 개발 (제13보). -농길리 추출물의 세포독성 및 항암작용에 관한 연구-
신민교,송호준,강영성,유홍선,한두석,강길웅,백승화,Shin, Min-Kyo,Song, Ho-Joon,Kang, Young-Sung,Ryu, Hong-Sun,Han, Du-Seok,Kang, Kil-Ung,Baek, Seung-Hwa 한국생약학회 1999 생약학회지 Vol.30 No.2
The cytotoxic and antitumor activity of Herba cratalariae sessiliflorae on cultured NIH 3T3 fibroblast and human oral epitheloid carcinoma cells were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) colorimetric method. The light microscopic study was carried out to observe morphological changes of cultured mouse fibroblast and human oral epitheloid carcinoma cells (KB). These results were obtained as follows; Ethyl acetate, chloroform and hexane extracts showed a significant cytotoxicity in NIH 3T3 fibroblast, but the other extracts did not show. All extracts exhibited a significant antitumor activity in human oral epitheloid carcinoma cells, but ethanol extract did not show a antitumor activity. Hexane extract showed low cytotoxic effect, but exhibited the most antitumor activity. The MTT absorbance in NIH 3T3 fibroblast was significantly decreased by treatment with chloroform, ethyl acetate and hexane extracts respectively. Human oral epitheloid carcinoma cells was significantly decreasd by treatment with all extracts with the exception of ethanol extract. The difference in MTT absorbance in two cell Types was most remarkable when treated with water and hexane extracts. Cholroform and hexane extracts showed the strongest effect in growth inhibition of human oral epitheloid carcinoma cells. These results indicated that water extract possessed no cytotoxicity and a strong antitumor activity.
이종화 ( Joung Hwa Lee ),양현웅 ( Hyun Woong Yang ),이강창 ( Kang Chang Lee ),박상면 ( Sang Myeon Park ),김상수 ( Sang Su Kim ),서부일 ( Bu Il Seo ),강영성 ( Young Seung Kang ),김성수 ( Seung Soo Kim ),황대룡 ( Dae Ryoung Hwang 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
N/A Objectives : To clarify the myocardial toxicity of FeSO_4 in cultured rat myocardial cells, toxic effect was measured by MTT assay. Methods : Myocardial cells were incubated for 12hours in the media containing 10~80㎛ concentrations of FeSO_4. And also, the protective effect of Alli Macrostemi Bulbus(AMB) was measured in these cultures. Results : Cell viability was remarkably decreased in a dose- and time-dependent manners when cultured myocardial cells were exposed to 40 ㎛ FeSO_4 for 12hours. In the cytoprotective effect of AMB on FeSO_4-induced cytotoxicity, AMB blocked the FeSO_4-induced myotoxicity in these cultures. Conclusions : From the above results, it is suggested that FeSO_4 is toxic on cultured rat myocardial cells and AMB is effective in the prevention of FeSO_4-induced myocardial toxicity.
골쇄보가 Streptomycin으로 손상된 생쥐의 배양 섬유모세포에 미치는 영향
박상면 ( Sang Myeon Park ),이종화 ( Joung Hwa Lee ),이강창 ( Kang Chang Lee ),양현웅 ( Hyun Woong Yang ),이병찬 ( Byung Chan Lee ),이정헌 ( Jung Hun Lee ),정종길 ( Jong Gil Jeong ),서부일 ( Bu Il Seo ),강영성 ( Young Seung Kang 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
N/A Objectives : To examine the cytotoxicity of streptomycin(STR) on cultured mouse fibroblasts, cytotoxocity-induced by STR was measured by MTT assay. Methods : Fibroblasts were cultured in the media containing various concentrations of STR for 72 hours. In addition, cytoprotective effect of Drynariase Rhizoma(DR) on STR-induced cytotoxicity in fibroblasts was examined when fibroblasts were preincubated with various concentrations of DR for 2 hours before treatment of 5 ㎍/ml STR for 72 hours. Results : STR decreased remarkably cell viability in a dependentmanner in these cultures, and also DR increased cell viability and amount of DNA synthesis damaged by STR. Conclusions : From the above results, it is suggested that STR has toxic effect in cultured mouse fibroblasts, and also DR was effective in the protection of STR-induced cytotoxicity in these cultures.