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고지방식이에 의한 비만 동물모델에서 유산균 마분말의 항비만 효과
박영미(Young Mi Park),오홍근(Hong Geun Oh),강양규(Yang Gyu Kang),김영필(Young Pill Kim),신홍식(Hong Sig Sin),장승환(Seung Hwan Jang),김희정(Hee Jeong Kim),이상왕(Sang Wang Lee),이학용(Hak Yong Lee) 한의병리학회 2015 동의생리병리학회지 Vol.22 No.2
The purpose of this study was to examine the antiobesity effects of lactic acid bacteria-fermented Dioscoreae Rhizoma powder (LDR) in Sprague-Dawley rats with high-fat diet (HFD)-induced obesity. Rats were divided into 5 groups: normal diet group, control (high fat diet-vehicle) group, 0.4 g/kg LDR (high fat diet + 0.4 g/kg lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 1 g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 2.5g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group. Our results indicate that LDR administration has effects on decreasing of body weight, fat weight, blood parameters and adipocyte size in the obesity animals. In addition, verified that fat degeneration and ballooning degeneration were alleviated in the experimental group fed on a high fat diet combined with LDR groups. These results indicate that lactic acid bacteria-fermented Dioscoreae Rhizoma powder may reduce elevating body weight and lipid accumulation in rat fed a high fat diet, suggesting its usefulness as a functional food for reducing body fat and obesity.
오홍근(Hong-Geun Oh),문대인(Dae-In Moon),김정훈(Jung-Hoon Kim),강영례(Young-Rye Kang),박정우(Jung-Woo Park),서민영(Min-Young Seo),박상훈(Sang-Hoon Park),강양규(Yang-Gyu Kang),최충현(Chung-Hyeon Choe),박인선(In-Sun Park),김주(Ju Kim) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.5
이 연구에서는 SD rat과 Mongolian gerbil에서 실험적으로 HCl-ethanol(150 mM HCl+60% ethanol)을 투여하여 급성 위염을 유발하고, H. pylori 감염시켜 만성 위염, 위궤양을 유발한 후, 건해삼을 투여하여 건해삼에 의한 항위염, 항위궤양 효과 및 H. pylori 감염 경향성 및 치료율을 검토하였던바 다음과 같은 결과를 얻었다. 7주령 SD rats와 H. pylori에 감염시킨 7주령 Mogolian gerbils를 정상군(Nor, n=6)과 대조군(Con, 60% HCl-ethanol+증류수(vehicle), n=6)에 비하여 실험군 Ⅰ(DSD Ⅰ, 60% HCl-ethanol+건해삼 30 ㎎/㎏, n=6), 실험군 Ⅱ(DSD Ⅱ, 60% HCl-ethanol+건해삼 100 ㎎/㎏, n=6), 실험군 Ⅲ(DSD Ⅲ, 60% HCl-ethanol+건해삼 300 ㎎/㎏, n=6)에서는 건해삼 투여 용량에 따른 항위염, 항위궤양 및 항헬리코박터 효과를 육안적 소견, CLO test 및 병리조직학적 검사를 통해 확인할 수 있었다. 이상의 결과를 종합해볼 때 건해삼이 새로운 위염 및 위손상 치료제와 기능성식품의 개발에 활용할 수 있음을 확인하였다. Sea cucumber, Stichopus japonicus, is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and H. pylori-infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n=6), control (Con, 60% HCl-ethanol+water, n=6), groupⅠ (DSCⅠ, 60% HCl-ethanol+sea cucumber 30 ㎎/㎏, n=6), groupⅡ (DSCⅡ, 60% HCl-ethanol+sea cucumber 100 ㎎/㎏, n=6), and group Ⅲ (DSCⅢ, 60% HCl-ethanol+sea cucumber 300 ㎎/㎏, n=6). Sea cucumber significantly suppressed gastric lesions and ulcers in the 60% HCl-ethanol-induced gastric model. Especially, 100 ㎎/kg of sea cucumber showed significantly inhibitory effects. In histopathological analysis of the H. pylori model, we found that sea cucumber augmented the eradication rates of H. pylori and attenuated gastric ulcer formation. Our results suggest that sea cucumber has inhibitory effects on gastritis and gastric ulcers. In addition, sea cucumber can be applied for the treatment of H. pylori.