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- 저자 : 강신국(Shin Kook Kang) (검색결과 2 건)
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현탁제 제조공정에서 발생된 거품이 완제품 주성분 함량에 미치는 영향
강신국(Shin Kook Kang),송민섭(Min Sub Song),신경오(Kyung Oh Shin),유광석(Kwang Suk You),한성수(Seong Soo Han),홍진태(Jin Tae Hong) 대한약학회 2022 약학회지 Vol.66 No.1
This study aimed to investigate the influence of foam generated in the pharmaceutical suspension manufacturing process on finished products’ active pharmaceutical ingredient (API) contents. In particular, we aimed to evaluate the possibility of having a higher API content in pharmaceutical suspensions containing a large amount of foam. We also investigated content analysis results based on prior studies related to the attachment of solid particles to bubbles. Each test tube was agitated at 1,200 rpm for 60 min to generate bubbles. To measure the API content, samples were collected from each layer (lower, middle, upper, foam). The API content analysis results were further analyzed by general properties (pH and density), surface hydrophobicity (contact angle), and morphological properties (particle size and shape). The API content in five out of seven pharmaceutical suspensions increased toward the upper layer, and the API concentration of the foam layer was the highest. The other two suspensions showed an opposite trend. The contact angle of API particles of products with an increased toward the upper layer was greater than 62o, the particle size exceeded 4μm, and the particles were needle-shaped and had angular fragments. Our findings indicate that API particles are highly concentrated in the foam generated during the manufacturing process depending on various properties, including surface hydrophobicity, particle size, and shape. Therefore, improvements in formulations and the manufacturing process of pharmaceutical suspensions such as foam suppression or breakage rather than foam removal from the intermediate products are required.
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박물관의 이미지 분석에 관한 연구 - 해외 박물관 사례를 중심으로 -
강신국(Kang Shin Kook),김기상(Kim Ki Sang),임채진(Lim Che Jin) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
The purpose of this study is to provide the design method of the museum to give proper visual characteristics. For this purpose, SD(Semantic Differential method) technique was conducted as the main research method and SPSS(Statistical Package for the Social Sciences) program was applied for statistical analysis. The results are summarized as follows.<br/> 1. The visual factors of museum are defined Legal Recognition, Order, Harmony, Pleasantness, Nature. 2. These visual factors are closely related to Shape, Organization, Atmosphere, Color and Quality of the Material, Location. Therefore, When planning and designing museum, these relationship can be applied very usefully in systematic.
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