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소아 편도적출술 후 Ketorolac과 함께 Fentanyl 또는 Butorphanol을 이용한 통증자가조절법
강동희(Dong Hee Kang),이정민(Jung Min Lee) 대한통증학회 1999 The Korean Journal of Pain Vol.12 No.2
N/A Background: Patient-controlled analgesia (PCA) has proven to be safe and effective in children from age 5 years, and older and compares favourably with continuous morphine infusion in the older child. We compared fentanyl and butorphanol for opioid use in PCA with ketorolac to determine a suitable drug combination for post-tonsillectomy pain control. Methods: We studied 60 patients, aged 5-12 yrs, undergoing tonsillectomy with or without ade- noidectomy under general anesthesia using N2O-O-enflurane. Patients were randomly assigned to receive fentanyl 250 μg (Group 1: n-30) or butorphanol 5 mg (Group 2: n-30) mixed with ketorolac 90 mg and ondansetron 4 mg diluting l00 ml of 5% D/W solutions intravenously via PCA pump after operation. PCA pump were programmed to deliver a 0.05 ml/kg loading dose, 0.01 ml/kg/hr basal infusion, 0.01 ml/kg on demand bolus, 6 min lockout intervals between doses and 4 bolus hourly limit. Total infusion dosage of PCA drug, VAS pain scores, side effects and satisfaction score of both groups were monitored for 48 hrs. Results: Total infusion dosages were fentanyl 170.6 pg with ketorolac 61.4 mg (Group 1) and butorphanol 2.8 mg with ketorolac 50.4 mg (Group 2). Total infusion dosage, quality of analgesia, side effects and overall satisfaction didn't differ between two groups. Conclusions: Both fentanyl and butorphanol mixed with ketorolac were effective for post-tonsillectomy pain control using PCA pump in children as young as 5 years old.
원심력기반 3차원 관성밸브 모델링을 통한 정밀 미세유체제어
강동희(Dong Hee Kang),김나경(Na Kyong Kim),강현욱(Hyun Wook Kang) 한국가시화정보학회 2021 한국가시화정보학회지 Vol.19 No.1
A three-dimensional slope valve component is used for controlling micro volume of liquid on a centrifugal force-based microfluidic disk platform, also called a lab-on-a-disk. The modeling factor of the slope valve component is determined to centrifugal force for liquid passing the crest of a slope valve via variation of slope length and angle as well as the radius to start point of slope valve. The centrifugal force is calculated by the equilibrium equation of the capillary and gravitational forces according to the microchannel surface roughness and the liquid volume, respectively. As a result, the slope valve is analyzed by the minimum angular velocity for liquid passing at crest point and the ratio between the length of micro liquid and slope length to obtain the factors for optimal slope angle modeling.
HS-SPME/GC-MS를 이용한 천연물 열수추출물 처리 돼지 막창의 휘발성 및 반휘발성 물질 분석
강동희(Dong-Hee Kang),전현욱(HyunWook Jeon),김현수(Hyun-Soo Kim) 한국생물공학회 2018 KSBB Journal Vol.33 No.2
Changes in volatile and semi-volatile compounds present in pork entrails and extracts-treated pork entrails were determined by gas chromatography mass spectrometry (GCMS) with headspace-solid phase microextraction (HS-SPME). A total of 45 compounds, including 16 aldehydes, 9 alcohols, 2 phenols, 2 ketones, 2 indoles, 1 amine, and 13 miscellaneous substances, were identified in pork entrails. A total of 42 compounds, comprising 15 aldehydes, 10 alcohols, 1 phenol, 2 indoles, 1 amine, and 13 miscellaneous constituents, were identified in extracts-treated pork entrails. Heptadecane, 2,3-octanedione, 4E-8-methyl-4-decene, 3E-3-ethyl-2-methyl-1,3- hexadiene, 2-octenal, 2,4-nonadienal, 2-undecenal, 2-ethoxybenzenaldehyde- 1-180, 2,3-octanedione, 2-pentadecanone, 1- hexanol and acetamide were detected in pork entrails alone. Area values of hexanal, heptanal, E-2-hexenal, 2-pentyl-furan, 1-pentanol, octanal, E-2-heptenal, nonanal, 1-octen-3-ol, 1-heptanol and benzaldehyde were decreased in extract-treated pork entrails rather than untreated pork entrails.
Zeolite가 첨가된 PVDF 전기방사 필름의 흡습 특성
강동희(Dong Hee Kang),김나경(Na Kyong Kim),강현욱(Hyun Wook Kang) 대한기계학회 2018 大韓機械學會論文集B Vol.42 No.5
전기방사기법을 통해 형성된 전기방사 필름은 단위부피당 높은 비표면적을 갖는 구조적인 특징과 더불어, 기계적, 전기적, 광학적 특성을 향상시키기 위한 금속 및 세라믹 나노입자의 첨가가 용이하기 때문에 액체 및 기체 필터, 약물전달, 전지분리막과 같은 다양한 분야에서 응용된다. 본 연구에서는 내화학성 특징을 갖는 polyvinylidene fluoride를 기반으로 하여 흡습 특성이 있는 zeolite가 첨가된 전기방사 필름의 수분 흡수 특성을 분석한다. Zeolite가 첨가된 전기방사 polyvinylidene fluoride 필름은 zeolite의 모세관 현상에 의해 수분 흡착이 발생하고, 연쇄적으로 필름의 다공성 구조 내부로 수분이 침투하는 현상이 나타난다. Zeolite가 포함된 전기방사 polyvinylidene fluoride 필름은 흡습 과정에서 형상 변화 없이 단위 질량 대비 4.2배의 수분 흡수 특성을 보인다. An electrospinning technique is simple method to fabricate porous structure with high surface area per unit volume. Addition of metal/ceramic nanoparticles in electrospinning process is possible to increase film characteristics such as mechanical, electrical and optical properties. Electrospun film shows various applications in diverse fields such as liquid and gas filter, drug delivery system and membrane for metal ion battery separator. In this investigation, we fabricate an electrospun zeolite embedded polyvinylidene fluoride (zeolite/PVDF) film for analysis the water absorption. The materials of polyvinylidene fluoride (PVDF) and zeolite have property with chemically resistance and water absorption, respectively. Electrospun zeolite/PVDF film shows water penetration phenomenon due to the capillary condensation by zeolite structure and is subsequently penetrated into porous structure of electrospun film. As a result, electrospun zeolite/PVDF film shows 4.2 times ratio absorbed mass of water per unit mass of film without deformation.
곤충병원성 선충에서 분리한 공생세균의 안정화 및 항진균활성
강동희(Dong-Hee Kang),김효현(Hyo-Hyun Kim),남욱호(Uk-Ho Nam),김현수(Hyun-Soo Kim) 한국생물공학회 2015 KSBB Journal Vol.30 No.3
In order to use the symbiotic bacteria from ethomophatogenic nematodes as a biological control agent for agriculture, the cultural condition for maintaining phase I and antifungal activity was investigated. Symbiotic bacteria (SB) 1 stain from nematodes were selected from the three strains isolated from entomopathogenic nematodes. The growth of the SB 1 strain in NB, TSB, TY and YS medium was higher than that of the SB 2 and SB 3 strain. The packed cell volume of the SB 1 strain was reduced in NB medium which showed radical pH change. Phase I of the SB 1 strain was maintained in TSB medium after being stored for 2 weeks at 4℃. Culture broth with the SB 1 strain in TSB medium for 6 days and 7 days showed antifungal activities against Rhizoctonia solani KACC 40142, Botrytis cinerea Pers. KACC 40854, and Botrytis cinerea Pers. KACC 41008. Culture broth with the SB 1 strain in TSB medium containing 100 mM L-proline for 5 days showed antifungal activities against Rhizoctonia solani KACC 40142, and Botrytis cinerea Pers. KACC 40854.
강동희 ( Dong Hee Kang ),김현수 ( Hyun Soo Kim ) 한국미생물생명공학회 2011 한국미생물·생명공학회지 Vol.39 No.3
Through the process of fermentation with Lactobacillus strains this study has evaluated the functionality of the traditional Korean medicine Bangpungtongsungsan after the addition of four other medicinal ingredients. In order to facilitate the growth of the Lactobacillus strains brown sugar was added to the herbal substances used. For both DPPH radical scavenging activities and SOD-like activities the medicinal mixture, when fermented through heterogeneous co-cultures, scored higher (at 77% and 42%, respectively) than when not fermented (at 31.7% and 36.3%, respectively). The co-cultured Korean medicine inhibited the growth of Bacillus subtilis PCI 219, Pseudomonas aeruginosa KCTC 2004, Staphylococcus aureus subsp. aureus KCTC 1916 and Propionibacterium acnes KCTC 3314. The inhibiting effects on β-hexosaminidase released from RBL-2H3 cells caused by the mixture, with and without fermentation, was seen to be similar (57% and 60%, respectively).
도꼬마리 추출물의 유산발효 특성 및 Helicobactor pylori 에 대한 항균활성
강동희(Kang, Dong Hee),김현수(Hyun-Soo Kim) 한국생물공학회 2010 KSBB Journal Vol.25 No.3
약용식물인 도꼬마리 추출물을 사용하여 유산균을 이용한 단일 및 복합배양을 통하여 새로운 기능성 물질의 생산을 검토하였다. 도꼬마리 추출물의 유산발효 시 단일배양 결과에서 유산생산을 통해 대체로 잘 증식하는 것이 확인되었으며, H. pylori의 항균 활성은 단일배양보다 복합배양 시항균활성이 아주 우수하였다. 항균성 물질의 분리는 C18 Seppak cartridge에 흡착시켜 30% methanol 용출획분에서 항균성물질이 확인되었으며, TLC로 분석한 결과 Rf 0.46의 위치에서 항균성 물질을 확인하였다. 도꼬마리 유산발효액의 항산 화활성은 총 polyphenol 함량 및 radical 소거능을 검토하였으며, 그 결과 총 polyphenol 함량은 미발효시에 비해 도꼬마리 추출물의 저농도에서 단일배양의 경우 2∼4배 증가하였으며, Lactobacillus brevis KCTC 3498과 Lactobacillus helveticus KCTC 3545를 복합배양한 경우 1 mg/mL 첨가농도에서 polyphenol이 가장 높게 나타났다. Radical 소거능은 도꼬마리 추출물을 0.1 및 0.5 mg/mL로 첨가하여 발효하였을 때 30∼40%의 scavenging이 확인되어 발효를 하지 않았을 때 (25%)보다 발효를 하였을 때 높아지는 것으로 나타났다. 특히 Lactobacillus casei KCTC 3109의 경우 0.1 mg/mL의 농도에서 70%의 scavenging을 나타내었다. 이들 결과로부터 도꼬마리 추출물의 유산발효는 미발효시에 비해 Helicobactor pylori에 대한 항균활성물질의 생산과 기능성물질인 항산화물질의 생산성이 우수하다고 사료되었으며 천연한약재의 발효를 통한 천연물 신약 등 신기능물질의 생산가능성을 확인하였다. This study characterized the anti-Helicobactor pylori activity of Xanthium strumarium L. extract obtained by lactic acid fermentation. The growth of the Lactobacillus strains was typically robust upon lactic acid production in monocultures containing Xanthium strumarium L. extract. Lactic acid fermentation in mixed cultures of Lactobacillus brevis KCTC 3498 and Lactobacillus casei KCTC 3109 produced higher of anti- H. pylori activity than monocultures. Concerning antioxidant activity of fermented extracts, total polyphenol contents were the highest in co-cultures of Lactobacillus brevis KCTC 3498 and Lactobacillus helveticus KCTC 3545. Electron donating ability using diphenyl picryl hydrazyl (DPPH) showed 70% scavenging in Lactobacillus casei KCTC 3109.