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Do Hyun Kang(강도현),Jinsang Kim(김진상) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
Phosphorescence, a delayed light emission generated by relaxation of excited electrons from a triplet excited state to the singlet ground state, has unique features such as a bright intensity, a large Stokes shift, a long lifetime, and an oxygen-sensitivity. Though these unique features can be exploited valuably in various biosensor applications, conventional phosphorescent materials are rare, unstable, non-biocompatible and expensive. Recently, metal-free purely organic phosphors have been discovered as a new class of phosphorescent material and have attracted great attention as a potential transducer of next biosensors. We designed lipid-polymer hybrid core-shell nanoparticles doped with metal-free organic phosphors to promote various phosphorescence-based biosensor applications. A nanoprecipitation-based fabrication method was also developed to fabricate the organic phosphorescent hybrid nanoparticles in a simple, rapid, and scalable way. The resulted lipid-coated phosphorescent nanoparticles show good stability and biocompatibility, as well as the bright phosphorescence emission and the moderate sensitivity to surrounding oxygen concentration. Therefore, the phosphorescent nanoparticles were successfully applied to two remarkable bioassays, cell-free DNA detection and in vivo retinal oxygen imaging.