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감성훈(Kam Seong Hoon),이효근(Lee Hyo Gun) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12
Jeong Yak-yong, a famous scholar in the Joseon Dynasty, developed an equipment which could carry heavy stuffs easily through the principle of a pulley while building the “Suwon-HwaSeoung”. It is true that his efforts contributed to the completion of the castle a lot, but he could have developed a model which is better than the one he suggested. Thus this study is aimed to reveal the possibility of building the better model stated in “GiGidoSul”. It will suggest several historical sources which show the great iron manufacturing technique in Joseon Dynasty and analyze it to demonstrate the possiblity of building a better model. Through these collaborative demonstration, it concludes that Jeong Yak-yong’s development was not the best one.
High Performance Liquid Chromatographic Analysis of Omeprazole in Human Plasma
Kam, Sung-Hoon,Lee, Yoo-Chul,Lee, Jang-Won,Chi, Sang-Cheol 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1
An HPLC procedure with UV detection has been developed fro the quantitation of omeprazole in human plasma. The drug and the intermal standard (benzocaine) were extracted from plasma with ethyl acetate and quantitated using a reverse-phase C_18 column. The chromatograms were completely free from interfering peaks, and the retention time of the omeprazole and the internal standard were 6.5 min and 10.0 min, respectively. Calibration plots were linear over the concentration range of 100∼1,000 ng/ml of omeprazole with the correlation coefficients all higher than 0.999. The mean interday precision and accuracy over three days were 3.12% and 4.02%, respectively. The mean interday precision and accuracy over three days were 3.12% and 4.02%, respectively. The mean recoveries over the entire calibration range were 96.2% for the drug and 91.3% for the internal standard. The limit of detection for omeprazole was 0.5 ng/ml. The method was simple, reliable and accurate for the quantitation of omeprazole in human plasma.
정재영,감성훈,김건남,지상철,박은석 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
The transdermal therapeutic system (TTS) of scopolamine has various advantages over its oral dosage forms. The ideal scopolamine TTS requires high skin permeation rate in short time after it is applied on the skin. In order to increase the initial skin permeation rate of scopolamine from TTS, various permeation enhancers were employed. Enhancers employed were fatty acids(oleic and linolenic acids), cyclic monoterpenes(menthol, camphor, cineole and limonene) and others(isopropyl myristate, sodium lauryl sulfate and glyceryl monostearate). The concentration of enhancers in the base were fixed to 5% (w/w). While fatty acids had little enhancing effect on the skin permeation of scopolamine, cyclic monoterpenes, isopropyl myristate and sodium lauryl sulfate resulted in 1.5∼2.36-fold higher skin permeation rate of the drug compared to the control. However, lag time was not affected by enhancers studied.
딜티아젬 함유 코아 펠렛으로부터 약물의 용출에 미치는 폴록사머 함량의 영향
이승우,감성훈,홍지웅,최기송,박은석,지상철 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4
In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50∼90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.
박은석,지상철,감성훈 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.2
In order to reduce the systemic side effects and the gastrointestinal irritation of indomethacin following its oral administration, the drug was formulated as a transdermal gel using poloxamer 407. In vitro diffusion cells fitted with excised rat skins were used to evaluate the effects of formulation variables on skin permeation of indomethacin from poloxamer gels. The formulation variables were the concentrations of indomethacin, poloxamer 407 and ethanol, and the gel pH. The increase of the drug amount in the gel from 0.5% to 2.0% induced a direct but nonlinear increase in the skin permeation rate of indomethacin. The increase of poloxamer concentration from 17.5% to 25% in the gel resulted in a decrease of skin permeation rate of indomethacin, which was due to a reduction in the amount of free drug molecules available for permeation through skin by entrapping more drug molecules within the micelles formed by poloxamer. The increase of ethanol concentration from 10% to 20% in the gel resulted in a linear increase of permeation rate of indomethacin through skin, possibly due to the penetration enhancing effect of ethanol. The skin permeation of indomethacin was substantially influenced by the gel pH, exhibiting a maximum at pH 4.
박천웅,이윤석,고병욱,이규현,이혜숙,박은석,감성훈 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
A simple and sensitive HPLC method for the analysis of rabeprazole in plasma is described using UV detection in the presence of lorazepam as the internal standard. Rabeprazole and lorazepam were extracted with ethyl ether and quantitated using a reverse-phase C18 column. The method was specific as there were no interfering peaks in the human plasma eluting at the retention times of rabeprazole and lorazepam. The method was fully validated in human plasma for the concentration range of 20.0-1000.0 ng/ml. The correlation coefficients were greater than 0.999. Extraction recoveries were 72.3% for the drug and 79.1% for the internal standard. The method was simple, reliable, and accurate for the quantitation of rabeprazole in human plasma. The same plasma samples, which were collected in healthy male volunteers administered a 20 mg tablet of Pariet®, were analyzed by HPLC and LC/MS/MS. As a result of that, there was no significant difference between pharmacokinetic parameters. The suitability of HPLC method for pharmacokinetic studies was verified by determining the relevant pharmacokinetic parameters.