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Syntheses and Biological Activity of Copolymer of N - Glycinyl maleimide(GMI) and Methacrylic acid
감기탁,정진곤,이능주,하창식,조원제 한국공업화학회 1993 한국공업화학회 연구논문 초록집 Vol.1993 No.0
The DIVEMA polymer reported by Butler et al.1 has been studied extensively for its broad biological activities such as antitumor, antiviral, anti -bacterial, interferon-induced and antifungal activity, Breslow et al. developed a method for synthesizing DIVEMA of narrow molecular weight distribution by photochemically initiated solution polymerization. We also synthesized several polymeric drugs containing 3,5-dioxo-4, 10-dioxa-tricyclo--[5.2.0<sup>2.6</sup>]dec-8-ene(DDTC) and investigated their biological activities. M.Fujimoto et al. and D.H.Rich et al. synthesized N-glycinyl maleimide (GMI) and D.H.Rich et al. reported the effects of GMI and other N-maleoylamino acids on vasopressin-stimulated water loss from isolated toad bladder. The aim of this work is to develop new polymers having biological activity from N-glycinyl maleimide (GMI). We expect that GMI has considerable biological activity because of its structural feature containing potential sites of negative charges as similar to maleic anhydride in DIVEMA. In this work, we synthesized poly(GMI-co-raethacy1ic acid)[poly(GMI-co-MA)] in 2-butanone with lauroylperoxide(LPO) at 70℃. The synthesized polymer was characterized by IR and <sup>1</sup>H-NMR spectroscopies, GPC and Elemental analysis. For biological tests, the cytotoxicities of GMI and poly(GMI-co-MA) were evaluated with K562 leukemia cell as a target cell. The antitumor activities of GMI and poly(GMI-co-MA) against sarcoma 180 were also investigated in vivo.